Educational guide
Peptide Solubilization
How to dissolve peptides? Solubility of Peptides Factors Influencing Peptide Solubility Guidelines for Peptide Solubility Dissolving Peptides and Troubleshooting 1. Short Peptides 2. Standard Peptides Assign a value of -1 to each acidic residue (D, E, and COOH
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How to dissolve peptides?
Solubility of Peptides
Factors Influencing Peptide Solubility
Guidelines for Peptide Solubility
Dissolving Peptides and Troubleshooting
1. Short Peptides
2. Standard Peptides
Assign a value of -1 to each acidic residue (D, E, and COOH at the C-terminus).
Assign a value of +1 to each basic residue (K, R, H and NH2 at the N-terminus).
Negatively charged peptides: First try water or buffer as a solvent. If this does not work, increase the pH by adding aqueous ammonia or 10% ammonium bicarbonate solution.
3. PepMixTM Peptide Pools
How to Dissolve Peptides:
Download Peptide Solubilization Protocol as PDF: Download
Can we help you?
We offer a solubility testing service based on Turbidimetric Solubility Assay (TSA). Take a look at our peptide solubility testing and other peptide analysis services.
If you have any further questions, please contact our experienced support teams!