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Peptide Deficiency May Contribute to Male Infertility - MPR

(HealthDay News) — Low levels of human β-defensin 1 (DEFB1) in sperm may explain some of the common causes of male infertility , according to research published in the August 13 issue of Science Translational Medicine . Ruiying Diao, of the First Affiliated Ho

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(HealthDay News) — Low levels of human β-defensin 1 (DEFB1) in sperm may explain some of the common causes of male infertility, according to research published in the August 13 issue of Science Translational Medicine.

Ruiying Diao, of the First Affiliated Hospital of Shenzhen University in China, and colleagues studied sperm and DEFB1 levels in men diagnosed with infertility caused by asthenozoospermia or leukocytospermia.

The researchers found low levels of DEFB1 in sperm from men with infertility caused by either asthenozoospermia or leukocytospermia, both of which are associated with reduced motility and reduced bactericidal activity in sperm. The same defects in sperm were observed when there was interference with DEFB1 function. Treatment with recombinant DEFB1 markedly restores DEFB1 expression, bactericidal activity, sperm quality, and egg-penetrating ability in sperm from men with asthenozoospermia or leukocytospermia. DEFB1 interacts with chemokine receptor type 6 (CCR6) in sperm and mobilizes Ca2+, which is involved in sperm motility. Interference with the function of CCR6 also reduces the motility and bactericidal activity of normal sperm.

“In closing, the demonstrated dual role of DEFB1 in defending male fertility and the involvement of DEFB1 and its interacting protein CCR6 in the pathogenesis of asthenozoospermia and leukocytospermia have suggested potential diagnostic targets and a feasible treatment method for male infertility associated with poor sperm motility and genital tract infection,” the authors write.

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Related questions

01Sperm speed and gender: Fact or fiction?

It’s long been thought that sperm with Y chromosomes, or “boy” sperm, swim faster than sperm with X chromosomes, known as “girl” sperm. The exact cause for low sperm motility can vary. Some men may have a genetic cause, while others may have an undiagnosed medical condition. Lifestyle and environmental factors also play a big role in sperm motility. Smoking, for example, has A condition called varicocele occurs when veins inside the scrotum become enlarged. This has also been linked to decreased sperm motility. Low sperm motility may also be due to a disorder in the male accessory sex gland secretion, which leads to the glands emptying more slowly. Sperm motility can be tested through a routine semen analysis. For the test, you’ll need to provide at least two semen samples. These are usually obtained by masturbation at a doctor’s office or testing facility. It’s also possible to obtain a sperm sample by having sex with a condom or withdrawing to obtain the sample. The sample must be kept at room temperature and delivered to the facility within 30 to 60 minutes. If less than 40 percent of your sperm are motile, your considered to have low sperm motility. In addition to sperm motility, your doctor can also use a semen analysis to test:

Source: www.healthline.com ↗
02Can You Improve Sperm Morphology Yourself?

‌It’s quite possible! Male fertility is a complex issue in which many factors play a role. Most scientists are adamant that fertilization is possible even in cases of severe structural abnormality among high percentages of sperm. Moreover, just as the body constantly builds and replaces its cells, it constantly builds and replaces its own sperm. The sperm that’s there today is quite literally not the sperm that will be there tomorrow, so many lifestyle changes can be made to improve all your body’s cellular “factories,” including its reproductive system. These include the following: ‌

Source: www.webmd.com ↗
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