PepMix Collection Melanoma Peptide Pools

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PepMix™ Collection Melanoma

US$4,741.10

Excluding tax and shipping fees

In stock

Description

About PepMix™ Collection Melanoma

Collection of 7 peptide pools derived from scans (overlapping peptides scans, 15mers with 11 aa overlap) through 7 tumor associated antigens (melanoma markers: MAGEA1, MAGEA3, MAGEA4, Melan-A/MART-1, Melanocyte protein Pmel 17 gp100, Tyrosinase, Tyrosinase-related protein 2) of Homo sapiens plus 2 control pools (CEF Pool (extended) and Actin)Amount: 9 peptide pools each containing 15nmol per peptide

PepMix™ Collection Melanoma - Specifications

Amount: 25 µg (approx. 15 nmol) / peptide (for stimulation of up to 2,5 x 108 cells)

Purity: Development Grade: each peptide purified to > 70% (HPLC/MS) - (equivalent to an average purity of 85%)

Delivery Format: Freeze-dried in 9 glass vials

Application(s): T-cell Immunity, Cancer biomarker research

Condition(s)/Topic(s): Cancer, Melanoma

Standard Delivery Time: 2-5 days

This PepMix Collection contains 7 different TAA PepMixes:

Human (MAGEA1)Human (MAGEA3)Human (MAGEA4)Human (Melan-A/MART-1)Human (Melanocyte protein Pmel 17 gp100)Human (Tyrosinase),Human (Tyrosinase-related protein 2)and as positive controls:CEF Pool (extended)Human (Actin)

Are you interested in your own custom PepMix? Choose your sequence, amount, purity and pool format. We will assist you along the way. Custom PepMix Peptide Pools.

PepMix™ Peptide PoolsProtein-spanning mixtures of overlapping peptides (PepMix™) are extremely efficient for- Antigen-specific T cell stimulation in T cell assays (e.g. in ELISpot, ICS, cell-mediated cytotoxicity or proliferation assays)- In-vitro T cell expansion- Dendritic cell pulsing- Immune monitoring- Cellular immune response profiling- T cell epitope identification- Standardization of T cell assays

Benefits of PepMix™- Each peptide quality controlled and guaranteed for identity and purity- CoA and HPLC-MS data available- High batch-to-batch consistency- No false positive T cell responses by contaminating deletion peptides- No toxic inhibition of T cell responses due to stringent purification of each peptide- Minimization of endotoxin contamination due to low bioburden process- ADCF policy in place- HLA independent stimulation (with antigen spanning peptide pools)

References

References for PepMix™ Collection Melanoma

ReferencesRead References with PepMix™ Peptide Pools for Infectious Diseases COVID-19 related PepMixes™ PepMix™ Control Pools

Application NotesCross-reactive T cells enhance immune responses in SARS-CoV-2 infection and vaccinationLoyal et al (2021) Full textPeptide Tools to Support the Fight against COVID-19Alem et al (2020) Full textCEFX/EFX Ultra SuperStim Pools: Superior positive controls for T-cell assays with broad MHC-allele and antigen coverageEckey et al. (2017) Full textDeveloping Multi-HIV Antigen Specific T-Cells as a Component of a Cure StrategyLam et al. (2015) Full textPeptide-stimulated Expansion of Virus-specific T cells For Preventative Treatment After Allogeneic Stem Cell TransplantationGary et al. (2015) Full textPepMix™ Peptide Pools for Clinical Applications: T Cell Therapy for Viral Infections after Hematopoietic Stem Cell TransplantKeirnan et al. (2012) Full textCytomegalovirus Protein Spanning PepMix™ Peptide Pools to Discover Changes in T-Cell Immunity in the Aging PopulationKern (2012) Full text

Documentation

Documentation for PepMix™ Collection Melanoma

Protocol_PepMix.pdf

PM-Collection-Melanoma.pdf

Product_Datasheet_PepMixCollection_Melanoma.pdf

Properties

Properties of PepMix™ Collection Melanoma

25 µg (approx. 15 nmol) / peptide (for stimulation of up to 2,5 x 108 cells)

Cancer biomarker research, T-cell immunity

PepMix Collections, PepMix Peptide Pools

Cancer, Melanoma

Freeze-dried in 9 glass vials, Freeze-dried in glass vial

Human

Selected proteins

>70% (HPLC-MS), Development Grade: each peptide purified to > 70% (HPLC/MS)

Further Information to PepMix™ Collection Melanoma

Values

7 different TAA PepMixes + 2 Controls (15mers, overlap 11):,Human (MAGEA1),Human (MAGEA3),Human (MAGEA4),Human (Melan-A/MART-1),Human (Melanocyte protein Pmel 17 gp100),Human (Tyrosinase),Human (Tyrosinase-related protein 2),CEF Pool (extended),Human (Actin) Copy Sequence Show complete Sequence Show trimmed Sequence

Peptide scan (15mers with 11 aa overlap); CEF control pool selected 9 mer peptides

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

Research context

Read sources and limitations before applying a claim.

TCR-T Research with PepMix™ Peptide Pools for Key Cancer Targets

Published on 15/05/2025 T-cell receptor-engineered T-cell therapy (TCR-T) is rapidly gaining momentum in the field of cancer immunotherapy. Unlike CAR-T cells, which recognize surface antigens, TCR-T cells can detect and eliminate cancer cells based on intracellular tumor-associated antigens presented by MHC molecules, offering broader therapeutic opportunities across solid and hematologic malignancies. A recent comprehensive review (Zhang et al., 2023) highlights the 16 major cancer targets currently pursued in TCR-T clinical trials. JPT is proud to support researchers in this exciting field by offering PepMix™ Peptide Pools for 15 of these 16 critical targets — and a partial PepMix™ for the remaining one (EGFRvIII). Main TCR-T Targets Available as PepMix™ Peptide Pools: AFP (Alpha-fetoprotein) EGFRvIII (partially available as ErbB2-ICD and ErbB2-ECD) EBV (Epstein-Barr Virus) HA-1 HBV (Hepatitis B Virus) HPV (Human Papillomavirus) KK-LC-1 KRAS (mutated) MAGE-A1 MAGE-A3 MAGE-A4 MAGE-A10 MART-1 Mesothelin NY-ESO-1 WT1 Check all our tumor-associated antigen peptide pools and our more than 1500 individual epitope peptides. Why Choose PepMix™ Peptide Pools for TCR-T Research? Comprehensive Antigen Coverage: Each PepMix™ consists of overlapping peptides that span the full protein sequence, ensuring maximal coverage of known and novel epitopes — ideal for discovery, monitoring, and functional assays. High Quality and Batch Consistency: Our optimized synthesis and stringent QC processes guarantee high purity, reproducibility, and biological performance you can trust for clinical research. Experience with Difficult Sequences: Hydrophobic and aggregation-prone sequences? No problem. JPT’s proven expertise ensures even challenging targets are fully represented in your peptide pool. Immediate Availability: More than 450 different catalog PepMix™ peptide pools are available from stock — enabling faster project initiation and smoother workflows. In case we do not have you antigen, contact us! We can provide it to you as a custom PepMix™ Peptide Pool. Accelerate Your TCR-T Research PepMix™ Peptide Pools are widely used for: Screening TCRs for target specificity Monitoring T-cell responses post-infusion Identifying immunodominant epitopes Supporting preclinical and translational studies Advance your TCR-T programs with reliable tools trusted by researchers worldwide and learn more about The World of PepMix™ or contact us!

Source: jpt.com ↗

JPT's Tumor Associated Antigens for Research

PepMix™ Peptide Pools are instrumental in cancer immunotherapy, particularly for exploring tumor-associated antigens and improving T cell responses. JPT’s PepMix™ Peptide Pools support the development of novel cancer vaccines and therapeutic strategies targeting tumor-specific markers. Below, you will find key studies referencing JPT’s PepMix™ Peptide Pools in research.

Source: jpt.com ↗

Practical and safety references

These excerpts are educational, not personalised medical instructions.

Potential benefits

Benefits of Custom PepMix™ Peptide Pools

Overlapping peptide pools are preferable to whole proteins for antigen-specific T-cell stimulation because: Simultaneous detection of CD4+ and CD8+ responses in a single sample Equivalent or better stimulation T-cell responses compared to whole protein antigens Antigen spanning peptide pools stimulate T-cells in an HLA independent manner All epitopes covered, epitope spreading addressed Purified peptide pools eliminate risk of toxic inhibition of T-cell responses No false positive T-cell stimulation caused by deletion peptides Superior control compared to phytohemagglutinin (PHA) and concanavalin A (ConA) Improved responses in stored blood and PBM cells compared to whole proteins High-batch-to-batch reproducibility Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation Prolonged shelf stability when stored freeze dried

Source: jpt.com ↗

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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PepMix™ Collection Melanoma

Description

About PepMix™ Collection Melanoma

PepMix™ Collection Melanoma - Specifications

References

References for PepMix™ Collection Melanoma

Documentation

Documentation for PepMix™ Collection Melanoma

Properties

Properties of PepMix™ Collection Melanoma

Further Information to PepMix™ Collection Melanoma

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