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Oxandrolone and RAD-140 Interaction: Avoid | Peptide Database

Compound Profiles Oxandrolone Oral Anabolic Steroid | Lean Mass & Recovery Oxandrolone exerts its anabolic effects primarily through binding to the intracellular androgen receptor (AR), promoting nitrogen retention and protein synthesis in skeletal muscle tiss

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This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Compound Profiles

Oxandrolone

Oral Anabolic Steroid | Lean Mass & Recovery

Oxandrolone exerts its anabolic effects primarily through binding to the intracellular androgen receptor (AR), promoting nitrogen retention and protein synthesis in skeletal muscle tissue. As a DHT derivative, it cannot be converted to estrogen by the aromatase enzyme, which means it does not cause estrogen-mediated water retention or gynecomastia.

RAD-140

Selective Androgen Receptor Modulator | Investigational SARM

RAD-140 binds to the androgen receptor (AR) with high affinity and selectivity, functioning as a full agonist in muscle and bone tissue while exhibiting minimal agonist activity in the prostate and other androgen-sensitive tissues. This tissue selectivity is achieved through differential cofactor recruitment: upon binding to the AR, RAD-140 induces a conformational change that favors interaction with coactivators predominantly expressed in skeletal muscle and bone, rather than those prevalent in prostate or sebaceous glands.

Combined Organ Load

Shared Safety Flags

Frequently Asked Questions

Can I take Oxandrolone with RAD-140?

Combining Oxandrolone with RAD-140 is not recommended. Both Oxandrolone and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently.

Is Oxandrolone and RAD-140 safe together?

This combination carries significant risk. Both Oxandrolone and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Consult a healthcare professional before combining.

What are the interactions between Oxandrolone and RAD-140?

Both Oxandrolone and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. This assessment has 53% confidence and is inferred from pharmacological mechanism analysis.

How should I time Oxandrolone and RAD-140?

Oxandrolone has a half-life of ~9-10 hours and RAD-140 has a half-life of ~60 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

This interaction analysis is compiled from research literature and pharmacological mechanism data. This assessment is inferred from known mechanisms and may not reflect all real-world outcomes. Always consult a healthcare professional before combining compounds.

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Research context

Read sources and limitations before applying a claim.

Research Indications

Supports bronchial tissue through gene expression regulation. Helps maintain respiratory epithelium health. Regulates protein synthesis in lung tissue. Addresses age-related changes in bronchial tissue. Modulates gene expression in respiratory cells.

Source: peptide-db.com ↗

Research Indications

YK-11's dual mechanism of AR agonism and myostatin inhibition theoretically positions it as a potent anabolic compound for increasing lean muscle mass. Cell culture data supports increased anabolic signaling and follistatin expression. However, there is no in vivo or clinical evidence confirming these effects in animals or humans. All efficacy reports are anecdotal. Users anecdotally report significant strength gains during YK-11 cycles, consistent with the compound's theoretical mechanism of action. The combination of AR-mediated protein synthesis and myostatin inhibition could theoretically support enhanced force production. No controlled studies exist to verify these claims. The most distinctive proposed benefit of YK-11 is its ability to upregulate follistatin and thereby inhibit myostatin-mediated limitations on muscle growth. In cell culture, YK-11 induced greater follistatin expression than DHT. If this translates to in vivo activity, it could allow muscle growth beyond normal physiological limits. This remains entirely unproven outside of cell-based assays. Follistatin has been shown in other research contexts to positively influence bone mineral density and bone formation. If YK-11's follistatin-inducing effects translate in vivo, there could be secondary benefits for bone density. This is entirely speculative and unsupported by any direct YK-11 bone data.

Source: peptide-db.com ↗
Practical and safety references

These excerpts are educational, not personalised medical instructions.

Dosage reference

Dosing Protocols

Masteron is administered exclusively via intramuscular injection. Two ester formulations exist: drostanolone propionate, the original pharmaceutical preparation with a short half-life requiring frequent injections (every other day or daily), and drostanolone enanthate, a longer-acting formulation produced by underground labs that permits less frequent dosing (twice weekly). Propionate remains the more widely used and available form. Cutting / Aesthetic Enhancement 300-400 mg/week Every other day (propionate) or 2x per week (enanthate) Intramuscular Contest Preparation 400-500 mg/week Every other day or daily (propionate) AI Replacement / Estrogen Management 200-300 mg/week

Source: peptide-db.com ↗
Side effects

Does rosuvastatin have the same muscle pain side effects as other statins?

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