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OSEA Seabiotic Water Cream Versus Biossance Squalane + Probiotic Gel Moisturizer

OSEA Seabiotic Water Cream Versus Biossance Squalane + Probiotic Gel Moisturizer This calming moisturizer is formulated around Squalane and Lactobacillus Ferment to calm redness and hydrate skin. This barrier-repair moisturizer is formulated around Squalane to

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

OSEA Seabiotic Water Cream Versus Biossance Squalane + Probiotic Gel Moisturizer

This calming moisturizer is formulated around Squalane and Lactobacillus Ferment to calm redness and hydrate skin.

This barrier-repair moisturizer is formulated around Squalane to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Caprylic/Capric Triglyceride

Squalane

Isoamyl Laurate

Undecane

Cetearyl Alcohol

Hectorite

Cetearyl Olivate

Sorbitan Olivate

Glyceryl Caprylate

Undaria Pinnatifida Extract

Tremella Fuciformis Polysaccharide

Hyaluronic Acid

Betulin

Tocopherol

Pavlova Lutheri Extract

Terminalia Ferdinandiana Fruit Extract

Laminaria Ochroleuca Extract

Bisabolol

Calendula Officinalis Flower Extract

Brassica Oleracea Italica Extract

Zingiber Officinale Root Extract

Melia Azadirachta Leaf Extract

Melia Azadirachta Flower Extract

Corallina Officinalis Extract

Coccinia Indica Fruit Extract

Solanum Melongena Fruit Extract

Aloe Barbadensis Flower Extract

Ocimum Sanctum Leaf Extract

Ocimum Basilicum Flower/Leaf Extract

Curcuma Longa Root Extract

Caesalpinia Spinosa Fruit Pod Extract

Helianthus Annuus Sprout Extract

Maltodextrin

Fucus Vesiculosus Extract

Lactobacillus Ferment

Tridecane

Sodium Stearoyl Glutamate

Caprylhydroxamic Acid

Tetrasodium Glutamate Diacetate

Sodium Hydroxide

Citric Acid

Sodium Benzoate

Potassium Sorbate

Water, Glycerin, Caprylic/Capric Triglyceride, Squalane, Isoamyl Laurate, Undecane, Cetearyl Alcohol, Hectorite, Cetearyl Olivate, Sorbitan Olivate, Glyceryl Caprylate, Undaria Pinnatifida Extract, Tremella Fuciformis Polysaccharide, Hyaluronic Acid, Betulin, Tocopherol, Pavlova Lutheri Extract, Terminalia Ferdinandiana Fruit Extract, Laminaria Ochroleuca Extract, Bisabolol, Calendula Officinalis Flower Extract, Brassica Oleracea Italica Extract, Zingiber Officinale Root Extract, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Corallina Officinalis Extract, Coccinia Indica Fruit Extract, Solanum Melongena Fruit Extract, Aloe Barbadensis Flower Extract, Ocimum Sanctum Leaf Extract, Ocimum Basilicum Flower/Leaf Extract, Curcuma Longa Root Extract, Caesalpinia Spinosa Fruit Pod Extract, Helianthus Annuus Sprout Extract, Maltodextrin, Fucus Vesiculosus Extract, Lactobacillus Ferment, Tridecane, Sodium Stearoyl Glutamate, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Sodium Benzoate, Potassium Sorbate

Lepidium Sativum Sprout Extract

Sodium Acrylates Copolymer

Phenoxyethanol

Capryloyl Glycerin/Sebacic Acid Copolymer

Lecithin

Caprylyl Glycol

Diheptyl Succinate

Isoeicosane

Allantoin

Sodium Phytate

Glycine Soja Sterols

Linoleic Acid

Phospholipids

Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment

Chondrus Crispus Extract

Sorbitan Oleate

Cellulose Gum

Chitosan

1,2-Hexanediol

Sodium Hyaluronate

Water, Glycerin, Squalane, Lepidium Sativum Sprout Extract, Sodium Acrylates Copolymer, Caprylic/Capric Triglyceride, Phenoxyethanol, Capryloyl Glycerin/Sebacic Acid Copolymer, Lecithin, Caprylyl Glycol, Diheptyl Succinate, Isoeicosane, Allantoin, Bisabolol, Sodium Phytate, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment, Chondrus Crispus Extract, Sorbitan Oleate, Cellulose Gum, Chitosan, 1,2-Hexanediol, Sodium Hyaluronate, Citric Acid, Potassium Sorbate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.

It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.

A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.

In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.

You'll likely see use concentrations quite low, usually 0.1-0.2%.

Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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