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Key takeaways

LL-37 is a cationic antimicrobial peptide that kills pathogens through membrane disruption and recruits immune cells via FPRL1 signaling. Making it essential for studies focused on innate immunity and wound healing.
VIP is a neuropeptide that suppresses pro-inflammatory cytokines (TNF-α, IL-6) by blocking NF-κB activation in macrophages and dendritic cells, with applications in autoimmune and neurodegenerative disease models.
LL-37 has a half-life of approximately six hours in vivo due to serum protein protection, while VIP's circulation half-life is only 1–2 minutes because of rapid DPP-IV enzymatic cleavage.
The two peptides are not interchangeable. LL-37 addresses pathogen defense and tissue repair at barrier surfaces, while VIP modulates systemic inflammation and neural signaling.
Stability handling differs significantly: LL-37 tolerates short-term storage at 4°C post-reconstitution, whereas VIP must be stored at −80°C and protected from oxidation to maintain activity.
Research teams investigating multi-pathway immune modulation increasingly use LL-37 and VIP in tandem. LL-37 for localized antimicrobial activity and VIP for downstream cytokine regulation.

realpeptides.co

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01Frequently Asked Questions About Products

Are the packages labelled as peptides? No, we respect your privacy. All orders and packages are sent unlabelled and include a return address if needed. How are the products stored before shipping? Our research chemicals are stored in a temperature-controlled environment at our storage facility. Where do your products come from? Our peptides are manufactured to order to ensure the finest quality at state-of-the-art facilities located in Europe and United States. Both facilities are compliant with GMP (Good Manufacturing Process) and ISO 9001 certifications. Can you tell me how to use your products? Please understand that we are a supply company, and we do not answer questions about the use or application of our products, you must do your own research. How can I be assured that your products are genuine? Our company’s success relies on your satisfaction and loyalty. That’s why we ensure our products are made under strict quality controls. If any product doesn’t meet our purity guarantee, we’ll replace your order at no extra cost to you. STORAGE FAQs

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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