Norditropin: Uses, Side Effects & Dosage | Healio

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Topics

Norditropin

Brand Names

Genotropin, Humatrope, Norditropin, Nutropin, Saizen, Serostim, Zorbtive

Generic Name

somatropin

Phonetic Name

(so-mah-TROW-pin)

Clinical Uses

Various brands of this medication are used for the treatment of one of the following medical conditions: growth failure, growth hormone deficiency, intestinal disorder (short bowel syndrome) or HIV-related weight loss or wasting. Somatropin is also used to increase height in children with certain disorders (such as Noonan syndrome, Turner syndrome, idiopathic short stature).

Dosage and Administration

Preparations

0.2 mg Brand(s): , 0.4 Genotropin Miniquick(R) for mg
0.6 mg Brand(s): , (supplied as a single-use subcutaneous
0.8 mg
1 mg Brand(s): , syringe device with cartridge use
1.2 mg Brand(s): , 1.4 and diluent), Pfizer mg
1.6 mg
1.8 mg Brand(s): , and
2 mg
4 mg
5 mg Brand(s): , Serostim(R) (supplied as and
6 mg Brand(s): single-dose or multi-dose vials), EMD Serono
5 mg Brand(s): and
12 mg Brand(s): Genotropin(R) (supplied in a cartridge with diluent, for use with Genotropin Pen(R) ), Pfizer
6 mg
12 mg Brand(s): , Humatrope(R) (6, 12, and
24 mg Brand(s): and
24 mg Brand(s): strengths are available as a single patient-use cartridge), Eli Lilly
5 mg Brand(s): and
10 mg Brand(s): Zomacton(R)
5.8 mg Brand(s): Omnitrope(R) (vial supplied with diluent), Sandoz Injection, for
5 mg/1.5 mL Brand(s): , Norditropin(R) (supplied in subcutaneous
10 mg/1.5 mL Brand(s): , single-patient-use FlexPro use
15 mg/1.5 mL Brand(s): , pen)
30 mg/3 mL
5 mg/1.5 mL Brand(s): Omnitrope(R) (supplied as and
10 mg/1.5 Brand(s): prefilled cartridge), Sandoz mL
5 mg/2 mL Brand(s): , 10 Nutropin AQ(R) NuSpin(R) mg/
2 mL Brand(s): , and (supplied as NuSpin prefilled
20 mg/2 mL Brand(s): injection device), Genentech
10 mg/2 mL Brand(s): and Nutropin AQ(R) (supplied as
20 mg/2 mL Brand(s): pen cartridge), Genentech

Administration Notes

Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using this medication and each time you get a refill. Ask your health care professional how to prepare and use this medication. If you have any questions, ask your doctor or pharmacist. Inject this medication under the skin as directed by your doctor. Some brands may also be injected into the muscle. Follow your doctor's instructions carefully. The dosage is based on your age, weight, medical condition and response to treatment. Do not shake the medication. Before using, check this product for particles or discoloration. If either is present, do not use the liquid. Before injecting each dose, clean the skin you are going to inject into (the injection site) with rubbing alcohol. Change the injection site each time to lessen injury under the skin. To lessen bruising, do not rub the injection site after a shot. Learn how to store and discard medical supplies safely. If you are using a pen device, do not share your pen device with another person, even if the needle is changed. You may give other people a serious infection, or get a serious infection from them. If this medicine is used for short bowel syndrome, consult your doctor if a special diet (high carbohydrate/low-fat) or the use of nutritional supplements may be helpful. If this medicine is used for weight loss/muscle wasting, it may take up to 2 weeks to notice the effects of the drug. Do not use more of this medication than prescribed or use it more often since the risk of side effects will be increased.

Missed Dose Instructions

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.

Label Warnings

Keep in refrigerator. Do not freeze. Refrigerate unopened product. May store at room temperature after opening for use. Do Not Shake. Swirl gently. Discard unused portion after the expiration date of _______________. Protect from light For single patient use only.

Indications

idiopathic short stature

adult growth hormone deficiency
growth failure associated with Turner's syndrome
growth failure due to Prader-Willi syndrome
pituitary dwarfism
short stature associated with Noonan syndrome
short stature in child born small for gestational age

Contraindications

acute respiratory failure
diabetic retinopathy
major traumatic injury
morbid obesity
sleep apnea

adrenocortical insufficiency
idiopathic intracranial hypertension
malignancy
pancreatitis
slipped capital epiphyses
snoring
untreated hypothyroidism

carpal tunnel syndrome
diabetes mellitus
edema
hypertension
progression of nevus
scoliosis

Common Adverse Effects

Acute abdominal pain
Arthralgia
Carpal tunnel syndrome
Edema
Headache disorder
Hematoma
Injection site sequelae
Lipodystrophy
Muscle rigidity
Myalgia
Peripheral edema

Acne vulgaris
Back pain
Hypoesthesia
Nausea
Paresthesia
Skin atrophy
Upper respiratory infection
Vomiting

Abnormal glucose tolerance
Acute bacterial otitis media
Alopecia
Body fluid retention
Fatigue
Fever
Gynecomastia
Hematuria
Increased appetite
Mood changes
Pharyngitis
Progression of nevus
Skin rash
Tonsillitis
Type 2 diabetes mellitus
Urinary tract infection

Serious Adverse Effects

Dyspnea
Hypertension
Hypothyroidism
Increased alanine transaminase
Increased aspartate transaminase

Acute pancreatitis
Adrenocortical insufficiency
Anaphylaxis
Angioedema
Diabetic retinopathy
Fracture
Gastroenteritis
Hyperglycemia
Hyperparathyroidism
Intracranial hypertension
Leukemia
Neoplasm
Papilledema
Pituitary insufficiency
Retinal disorder
Sleep apnea
Slipped capital epiphyses

Elderly Precautions

SeverityNarrativeManagement or Monitoring PrecautionEndocrine-Somatropin decreases sensitivity to insulin and may result in hyperglycemia in susceptible elderly, particularly with risk factors for diabetes mellitus. General-Associated with edema, arthralgia, carpal tunnel syndrome and gynecomastia. Lower starting doses are generally recommended in the elderly due to increased susceptibility to adverse effects.

Pregnancy Precautions

PrecautionSeverityNarrativeSOMATROPINRequires a Risk/Benefit AssessmentInsufficient human data available. Consider using a benzyl alcohol-free formulation. Benzyl alcohol has been associated with serious adverse events and death in infants and neonates. Consider pregnant patient treatment benefits versus potential fetal/neonatal adverse outcomes. Animal data does not suggest developmental toxicity.

Lactation Precautions

SeverityNarrativePrecautionINSUFFICIENT HUMAN DATA AVAILABLE

Pediatric Precautions

SeverityNarrativeManagement or Monitoring PrecautionMonitor for: pancreatitis, scoliosis progression, slipped femoral epiphysis, osteonecrosis, fluid retention, glucose intolerance, tumor progression/recurrence [if applicable]. Contraindicated if epiphyses are closed. Do not use in Prader-Willi patients who are severely obese, have upper airway obstruction, sleep apnea or severe respiratory impairment; use contraindicated due to risk of sudden death.

Drug Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Somatropin is very similar to lonapegsomatropin. Do not use medications containing lonapegsomatropin while using somatropin.

Drug Interactions Table

Storage Requirements

Consult the product instructions and your pharmacist for storage details. Keep all medications away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

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Selected from data included with permission and copyrighted by FDB, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution in professional health care settings.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of your healthcare professional. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you. You should consult your healthcare professional before taking any drug, changing your diet or commencing or discontinuing any course of treatment. See our full terms of use.

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking any drug or commencing or discontinuing any course of treatment.