Niod Multi-Molecular Hyaluronic Complex Versus Hylamide SubQ Skin

Niod Multi-Molecular Hyaluronic Complex Versus Hylamide SubQ Skin

This hydrating serum is formulated around Sodium Hyaluronate Crosspolymer and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.

This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Sodium Hyaluronate Crosspolymer to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Hydrolyzed Yeast Extract

Sodium Hyaluronate Crosspolymer

Dimethyl Isosorbide

Pentylene Glycol

Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Sodium Butyroyl Hyaluronate

Polyacrylate Crosspolymer-6

Disodium Acetyl Glucosamine Phosphate

Betaine

Trisodium Ethylenediamine Disuccinate

Yeast Extract

Cetyl Hydroxyethylcellulose

Tamarindus Indica Seed Gum

Tremella Fuciformis Sporocarp Extract

Lecithin

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Myristoyl Nonapeptide-3

Magnesium Chloride

Sodium Benzoate

Potassium Sorbate

PPG-26-Buteth-26

PEG-40 Hydrogenated Castor Oil

Ethylhexylglycerin

Chlorphenesin

Phenoxyethanol

Polyglucuronic Acid

Water, Glycerin, Hydrolyzed Yeast Extract, Sodium Hyaluronate Crosspolymer, Dimethyl Isosorbide, Pentylene Glycol, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Butyroyl Hyaluronate, Polyacrylate Crosspolymer-6, Disodium Acetyl Glucosamine Phosphate, Betaine, Trisodium Ethylenediamine Disuccinate, Yeast Extract, Cetyl Hydroxyethylcellulose, Tamarindus Indica Seed Gum, Tremella Fuciformis Sporocarp Extract, Lecithin, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Myristoyl Nonapeptide-3, Magnesium Chloride, Sodium Benzoate, Potassium Sorbate, PPG-26-Buteth-26, PEG-40 Hydrogenated Castor Oil, Ethylhexylglycerin, Chlorphenesin, Phenoxyethanol, Polyglucuronic Acid

Palmitoyl Tripeptide-38

Copper Lysinate/Prolinate

Methylglucoside Phosphate

Ahnfeltia Concinna Extract

Saccharide Isomerate

Lactobacillus/Eriodictyon Californicum Ferment Extract

Pseudoalteromonas Ferment Extract

Phospholipids

Hydroxypropyl Cyclodextrin

Hexylene Glycol

Salicylic Acid

Citric Acid

Sodium Citrate

Sodium Hydroxide

Ethoxydiglycol

Leuconostoc/Radish Root Ferment Filtrate

Caprylyl Glycol

Water, Glycerin, Hydrolyzed Yeast Extract, Pentylene Glycol, Tamarindus Indica Seed Gum, Sodium Hyaluronate Crosspolymer, Palmitoyl Tripeptide-38, Myristoyl Nonapeptide-3, Copper Lysinate/Prolinate, Methylglucoside Phosphate, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate, Ahnfeltia Concinna Extract, Saccharide Isomerate, Polyglucuronic Acid, Lactobacillus/Eriodictyon Californicum Ferment Extract, Pseudoalteromonas Ferment Extract, Phospholipids, Lecithin, Hydroxypropyl Cyclodextrin, Cetyl Hydroxyethylcellulose, Polyacrylate Crosspolymer-6, Hexylene Glycol, Salicylic Acid, Citric Acid, Sodium Citrate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Leuconostoc/Radish Root Ferment Filtrate, Sodium Benzoate, Potassium Sorbate, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Chlorphenesin

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

We don't have a description for Cetyl Hydroxyethylcellulose yet.

Chlorphenesin is a synthetic preservative. It helps protect a product against bacteria in order to extend shelf life. In most cases, Chlorphenesin is paired with other preservatives such as phenoxyethanol and caprylyl glycol.

Chlorphenesin is a biocide. This means it is able to help fight the microorganisms on our skin. It is also able to fight odor-releasing bacteria.

Chlorphenesin is soluble in both water and glycerin.

Studies show Chlorphenesin is easily absorbed by our skin. You should speak with a skincare professional if you have concerns about using Chlorphenesin.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This ingredient is created by putting sodium hyaluronate through hydrolysis.

You might know this as 'mini' or 'ultra low-molecular weight' hyaluronic acid. The small molecule size means it is able to travel deeper in the skin.

According to studies, low molecular-weight hyaluronic acid can:

One study from 2011 found ultra-low weight HA to show pro-inflammatory properties. Another study from 2022 found it to downregulate UV-B induced inflammation.

Hydrolysis is a process of changing a molecule using water or enzymes.

This ingredient is water-soluble.

We don't have a description for Hydrolyzed Yeast Extract yet.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Myristoyl Nonapeptide-3 is a peptide.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polyacrylate Crosspolymer-6 is a texture enhancer and pH adjuster.

It is be used to thicken water-based products and create a gel-texture with a velvet feel.

One manufacturer claims this ingredient to have a pH range of 2-8 and to be biodegradable.

This ingredient is also known as Sepimax Zen.

We don't have a description for Polyglucuronic Acid yet.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.

A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.

A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.

More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.

Tamarindus Indica Seed Gum is from the seeds of Tamarindus indica. It is more commonly known as tamarind.

Tamarindus Indica Seed Gum is used as a texture enhancer, emulsifier, and skin conditioner.

When added to products, Tamarindus Indica Seed Gum helps thicken and create a gel-like texture.

Tamarindus Indica Seed Gum is a humectant. It helps draw moisture from the air to your skin. This keeps your skin hydrated.

Emulsion stabilizing ingredients help stabilize a product. They work by stabilizing two non-mixable ingredients. An example would be oil and water.

Trisodium Ethylenediamine Disuccinate is used to help stabilize a product.

It is a chelating agent, meaning it helps prevent metal ions from binding to other ingredients. This prevents unwanted reactions in products. Metal ions can come into a product via the water ingredient. They are found in trace amounts and are not known to be harmful.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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