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Neutrogena Rapid Wrinkle Repair Eye Cream with Hyaluronic Acid Versus Estée Lauder Advanced Night Repair Eye Concentrate Matrix Synchronized Recovery Complex

Neutrogena Rapid Wrinkle Repair Eye Cream with Hyaluronic Acid Versus Estée Lauder Advanced Night Repair Eye Concentrate Matrix Synchronized Recovery Complex This anti-aging eye moisturizer is formulated around Retinol and Sodium Hyaluronate to soften the look

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Neutrogena Rapid Wrinkle Repair Eye Cream with Hyaluronic Acid Versus Estée Lauder Advanced Night Repair Eye Concentrate Matrix Synchronized Recovery Complex

This anti-aging eye moisturizer is formulated around Retinol and Sodium Hyaluronate to soften the look of wrinkles and hydrate skin.

This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Pentaerythrityl Tetraethylhexanoate

Dimethicone

Glycerin

PPG-15 Stearyl Ether

Cetearyl Alcohol

Stearyl Alcohol

Butylene Glycol

Ceteareth-20

Isohexadecane

Trisiloxane

Dimethicone Crosspolymer

Phenoxyethanol

Caprylyl Glycol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Polyacrylamide

Polyethylene

Chlorphenesin

C13-14 Isoparaffin

Ptfe

Hydrolyzed Myrtus Communis Leaf Extract

BHT

Sodium Hyaluronate

Disodium EDTA

Laureth-7

Ascorbic Acid

Polysorbate 20

Retinol

Sodium Hydroxide

Water, Pentaerythrityl Tetraethylhexanoate, Dimethicone, Glycerin, PPG-15 Stearyl Ether, Cetearyl Alcohol, Stearyl Alcohol, Butylene Glycol, Ceteareth-20, Isohexadecane, Trisiloxane, Dimethicone Crosspolymer, Phenoxyethanol, Caprylyl Glycol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Polyacrylamide, Polyethylene, Chlorphenesin, C13-14 Isoparaffin, Ptfe, Hydrolyzed Myrtus Communis Leaf Extract, BHT, Sodium Hyaluronate, Disodium EDTA, Laureth-7, Ascorbic Acid, Polysorbate 20, Retinol, Sodium Hydroxide

Bifida Ferment Lysate

Bis-PEG-18 Methyl Ether Dimethyl Silane

PEG-10 Dimethicone

Disteardimonium Hectorite

Isopropyl Isostearate

Sucrose

Trehalose

Adansonia Digitata Seed Extract

Tripeptide-32

Faex Extract

Lactobacillus Ferment

Algae Extract

Sodium Rna

Hydrolyzed Algin

Caffeine

Hydroxyethyl Urea

Aminopropyl Ascorbyl Phosphate

Cucumis Sativus Fruit Extract

Anthemis Nobilis Flower Extract

Hordeum Vulgare Extract

Silybum Marianum Extract

Glycine Soja Seed Extract

Camelina Sativa Seed Oil

Sorbitol

Betula Alba Bark Extract

Scutellaria Baicalensis Root Extract

Morus Bombycis Root Extract

Poria Cocos Sclerotium Extract

Tocopheryl Acetate

Propylene Glycol Dicaprate

Sodium Polyaspartate

Hydrogenated Lecithin

Phytosphingosine

Ethylhexylglycerin

Polysilicone-11

Isododecane

Helianthus Annuus Seed Extract

Propylene Carbonate

Polyacrylate Crosspolymer-6

Lecithin

Glucose

Fructose

T-Butyl Alcohol

Hydroxyacetophenone

Sodium Dehydroacetate

Potassium Sorbate

CI 77491

Water, Dimethicone, Bifida Ferment Lysate, Isohexadecane, Glycerin, Butylene Glycol, Bis-PEG-18 Methyl Ether Dimethyl Silane, PEG-10 Dimethicone, Disteardimonium Hectorite, Isopropyl Isostearate, PPG-15 Stearyl Ether, Sucrose, Trehalose, Adansonia Digitata Seed Extract, Tripeptide-32, Faex Extract, Sodium Hyaluronate, Lactobacillus Ferment, Algae Extract, Sodium Rna, Hydrolyzed Algin, Caffeine, Hydroxyethyl Urea, Aminopropyl Ascorbyl Phosphate, Cucumis Sativus Fruit Extract, Anthemis Nobilis Flower Extract, Hordeum Vulgare Extract, Silybum Marianum Extract, Glycine Soja Seed Extract, Camelina Sativa Seed Oil, Sorbitol, Betula Alba Bark Extract, Scutellaria Baicalensis Root Extract, Morus Bombycis Root Extract, Poria Cocos Sclerotium Extract, Tocopheryl Acetate, Propylene Glycol Dicaprate, Sodium Polyaspartate, Hydrogenated Lecithin, Phytosphingosine, Ethylhexylglycerin, Polysilicone-11, Isododecane, Helianthus Annuus Seed Extract, Polyethylene, Propylene Carbonate, Polyacrylate Crosspolymer-6, Lecithin, Glucose, Fructose, T-Butyl Alcohol, Disodium EDTA, BHT, Hydroxyacetophenone, Sodium Dehydroacetate, Potassium Sorbate, Phenoxyethanol, CI 77491

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

BHT is a synthetic antioxidant and preservative.

As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.

Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polyethylene is a synthetic ingredient that helps the skin retain moisture. It is a polymer.

It is also typically used within product formulations to help bind solid ingredients together and thicken oil-based ingredients. When added to balms and emulsions, it helps increase the melting point temperature.

We don't have a description for PPG-15 Stearyl Ether yet.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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