N-Telopeptide, Cross-Linked, Urine - ARUP Laboratories

Ordering Recommendation

Recommendations when to order or not order the test. May include related or preferred tests.

New York DOH Approval Status

Indicates whether a test has been approved by the New York State Department of Health.

This test is New York state approved.

Specimen Required

Patient PreparationInstructions patient must follow before/during specimen collection.

For monitoring therapy, a baseline specimen should be collected prior to initiation of therapy. Subsequent specimens for comparison should be collected at the same time of day as the baseline specimen.

CollectSpecimen type to collect. May include collection media, tubes, kits, etc.

Second-morning void or 24-hour urine. Refrigerate during collection. Collect without preservative.

Specimen PreparationInstructions for specimen prep before/after collection and prior to transport.

Transfer a 1 mL aliquot of urine from a well-mixed, second-morning void or 24-hour collection to an ARUP Standard Transport Tube. (Min: 0.5 mL)

Storage/Transport TemperaturePreferred temperatures for storage prior to and during shipping to ARUP. See Stability for additional info.

Frozen.

Unacceptable ConditionsCommon conditions under which a specimen will be rejected.

Specimens contaminated with blood or extensive hemolysis.

StabilityAcceptable times/temperatures for specimens. Times include storage and transport time to ARUP.

Ambient: 24 hours; Refrigerated: 1 week; Frozen: 4 weeks

Methodology

Process(es) used to perform the test.

Quantitative Chemiluminescent Immunoassay (CLIA)

Performed

Days of the week the test is performed.

Tue-Sat

Reported

Expected turnaround time for a result, beginning when ARUP has received the specimen.

1-4 days

Reference Interval

Normal range/expected value(s) for a specific disease state. May also include abnormal ranges.

Age	Male	Female
7-9 years	167-578 nM BCE/mM creatinine	201-626 nM BCE/mM creatinine
10-12 years	152-505 nM BCE/mM creatinine	173-728 nM BCE/mM creatinine
13-15 years	103-776 nM BCE/mM creatinine	38-515 nM BCE/mM creatinine
16-17 years	34-313 nM BCE/mM creatinine	20-144 nM BCE/mM creatinine
18 years and older	21-83 nM BCE/mM creatinine
Premenopausal		17-94 nM BCE/mM creatinine
Postmenopausal		26-124 nM BCE/mM creatinine

Interpretive Data

May include disease information, patient result explanation, recommendations, or details of testing.

NTx Units = nM BCE/mM creatinine

A decrease of 30-40% from the NTx baseline after three months of therapy is a typical response to anti-resorptive therapy.

NTx = Cross-linked N-telopeptide of Type I Collagen
BCE = Bone Collagen Equivalent

Compliance Category

FDA

Note

Additional information related to the test.

Hotline History

N/A

CPT Codes

The American Medical Association Current Procedural Terminology (CPT) codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually.
CPT codes are provided only as guidance to assist clients with billing. ARUP strongly recommends that clients confirm CPT codes with their Medicare administrative contractor, as requirements may differ.
CPT coding is the sole responsibility of the billing party. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published.

82523

Components

Components of test

Component Test Code*	Component Chart Name	LOINC
0020207	Creatinine, Urine - per volume	35674-1
0070061	NTx, Urine (nM BCE/mM Creatinine)	14115-0

* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

Other names that describe the test. Synonyms.

• Collagen Crosslinks
• N-Telopeptide, Urine
• NTx
• NTX Creatinine
• NTX Urine
• Cross-Linked N-Telopeptide
• Crosslinked N-telopeptide of Type I Collagen
• Osteomark
• Osteoporosis

N-Telopeptide, Cross-Linked, Urine