Miguhara EGF Crystal 10 PPM Origin Versus Wellage Hyper Peptide Botuleedle Ampoule

Miguhara EGF Crystal 10 PPM Origin Versus Wellage Hyper Peptide Botuleedle Ampoule

This anti-aging serum is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging ampoule is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Streptomyces Pulveraceus Ferment Filtrate

Oligopeptide-1

Sodium Hyaluronate

Glycerin

Beta-Glucan

Lactobacillus

Panthenol

1,2-Hexanediol

Hydroxyethylcellulose

Acetyl Hexapeptide-8

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Orchid Leaf/Root/Stem Extract

Bee Venom

Xanthan Gum

Adenosine

Disodium EDTA

Streptomyces Pulveraceus Ferment Filtrate, Oligopeptide-1, Sodium Hyaluronate, Glycerin, Beta-Glucan, Lactobacillus, Panthenol, 1,2-Hexanediol, Hydroxyethylcellulose, Acetyl Hexapeptide-8, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Orchid Leaf/Root/Stem Extract, Bee Venom, Xanthan Gum, Adenosine, Disodium EDTA

Water

Butylene Glycol

Propanediol

Carbomer

Hydroxyacetophenone

Cetyl Ethylhexanoate

Ethylhexyl Palmitate

Squalane

Tromethamine

Sucrose

Magnesium Stearate

Caprylic/Capric Triglyceride

Glycereth-25 PCA Isostearate

Hydrolyzed Sponge

Ethylhexylglycerin

Hydrogenated Lecithin

Hydrolyzed Gardenia Florida Extract

Hydrolyzed Malt Extract

Citric Acid

Hydrolyzed Viola Tricolor Extract

Hyaluronic Acid

Hydrolyzed Hyaluronic Acid

Pantolactone

Tripeptide-1

Sr-Clostridium Botulinum Polypeptide-1

Palmitoyl Pentapeptide-4

Sodium DNA

Sodium Acetylated Hyaluronate

Oenothera Biennis Flower Extract

Maranta Arundinacea Root Extract

Pinus Densiflora Leaf Extract

Ulmus Davidiana Root Extract

Water, Butylene Glycol, Glycerin, Propanediol, 1,2-Hexanediol, Panthenol, Carbomer, Hydroxyacetophenone, Cetyl Ethylhexanoate, Ethylhexyl Palmitate, Squalane, Tromethamine, Sucrose, Magnesium Stearate, Caprylic/Capric Triglyceride, Glycereth-25 PCA Isostearate, Hydrolyzed Sponge, Ethylhexylglycerin, Hydrogenated Lecithin, Adenosine, Disodium EDTA, Hydrolyzed Gardenia Florida Extract, Hydrolyzed Malt Extract, Citric Acid, Hydrolyzed Viola Tricolor Extract, Xanthan Gum, Sodium Hyaluronate, Hyaluronic Acid, Hydrolyzed Hyaluronic Acid, Pantolactone, Tripeptide-1, Sr-Clostridium Botulinum Polypeptide-1, Acetyl Hexapeptide-8, Palmitoyl Pentapeptide-4, Sodium DNA, Sodium Acetylated Hyaluronate, Oenothera Biennis Flower Extract, Maranta Arundinacea Root Extract, Pinus Densiflora Leaf Extract, Ulmus Davidiana Root Extract

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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