Metabolic Peptides: AOD-9604, Cagrilintide & More (2026)

For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

5 peptides in this class

5-Amino-1MQ

Target: NNMT (nicotinamide N-methyltransferase) inhibitor

5-Amino-1MQ is a small molecule that inhibits NNMT (nicotinamide N-methyltransferase), an enzyme linked to fat accumulation and metabolic dysfunction. By blocking NNMT, it may increase NAD+ levels, boost cellular energy, promote fat loss, and support metabolic health. Studied for obesity, type 2 diabetes, and longevity applications.

AOD-9604

Target: C-terminal hGH fragment (fat metabolism)

AOD-9604 is a modified fragment of human growth hormone (HGH fragment 176-191) studied for fat metabolism and weight loss. It mimics GH's lipolytic effects without affecting blood sugar or growth. Previously in clinical trials for obesity; now popular in research settings.

Cagrilintide

Target: Amylin & calcitonin receptors

Cagrilintide is Novo Nordisk's long-acting amylin analog designed for weight management. Phase 2 trials showed 11.8% body weight loss as monotherapy and up to 17.1% when combined with semaglutide (CagriSema). Works by enhancing satiety and slowing gastric emptying through amylin receptor activation.

SLU-PP-332

Target: ERRα/β/γ (estrogen-related receptor pan-agonist)

A small-molecule ERR receptor agonist that acts like exercise inside your cells — driving mitochondrial biogenesis, fat oxidation, and endurance gains without any actual training.

Tesofensine

Target: Serotonin–norepinephrine–dopamine reuptake inhibitor

Tesofensine is a serotonin-noradrenaline-dopamine reuptake inhibitor (SNDRI) originally developed for Parkinson's and Alzheimer's disease. Phase 2 trials showed remarkable weight loss of up to 12.8% over 6 months — more than double most approved obesity drugs. Works by reducing appetite and increasing satiety through triple monoamine reuptake inhibition.

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Helpful context for this guide

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Key takeaways

GLP-1 receptor agonists like semaglutide achieve 10–20% body weight reduction by delaying gastric emptying and extending satiety hormone elevation, but 40% of weight lost is lean tissue, not fat alone.
5-Amino-1MQ activates the AMPK pathway through NNMT inhibition, shifting cellular fuel preference toward fat oxidation without suppressing appetite. Allowing fat loss under maintenance calorie conditions.
AOD9604 stimulates lipolysis via beta-3 adrenergic receptors without raising systemic growth hormone or affecting glucose metabolism, avoiding the insulin resistance and joint side effects of full-length GH.
Growth hormone secretagogues (ipamorelin, CJC-1295) preserve lean mass during caloric restriction, which GLP-1 agonists do not. Making them preferable when body composition rather than scale weight is the primary research endpoint.
Combination protocols pairing GLP-1 agonists (intake reduction) with AMPK activators (oxidation increase) address both sides of energy balance simultaneously, producing greater fat loss than single-agent approaches in controlled research models.
Half-life dictates dosing frequency: semaglutide and tirzepatide require weekly administration due to 5-day half-lives, while liraglutide's 13-hour half-life necessitates daily dosing.

realpeptides.co

Research context

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Summary of Research Implications

The field of metabolic research has diversified significantly. It now encompasses a multi-pronged approach: modulating central satiety via neurotransmitters, altering adipose tissue enzymatics (5-Amino-1MQ), and mimicking the cellular signals of exercise (SLU-PP-332, AICAR). As researchers continue to map these pathways, the potential to address metabolic dysregulation at its root, cellular efficiency, becomes increasingly tangible.

Source: purehealthpeptides.com ↗

Practical and safety references

These excerpts are educational, not personalised medical instructions.

Dosage reference

What is a peptide dosage calculator?

A peptide dosage calculator is a free tool that converts your vial size, bacteriostatic water volume, and target dose into an exact syringe draw volume. Instead of doing the reconstitution math by hand, you enter three inputs and instantly get the concentration of your solution and how many milliliters or syringe units to draw. This calculator works for single peptide compounds and multi-peptide blends.

Source: peptidemind.com ↗

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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