MEDI-PEEL Premium Peptide Naite 1000 Neck Stick Versus MEDI-PEEL Premium 2.0 Collagen Naite Thread Neck Cream

MEDI-PEEL Premium Peptide Naite 1000 Neck Stick Versus MEDI-PEEL Premium 2.0 Collagen Naite Thread Neck Cream

This anti-aging moisturizer is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging moisturizer is formulated around Palmitoyl Tripeptide-5 and Dipeptide Diaminobutyroyl Benzylamide Diacetate to soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dicaprylyl Carbonate

Butylene Glycol

Hydrogenated Poly(C6-14 Olefin)

Ceresin

Synthetic Wax

Stearyl Dimethicone

C13-15 Alkane

Glycerin

Caprylic/Capric Triglyceride

Hdi/Trimethylol Hexyllactone Crosspolymer

Niacinamide

Dimethicone

Cetyl PEG/PPG-10/1 Dimethicone

Polymethyl Methacrylate

1,2-Hexanediol

Sorbitan Olivate

C10-18 Triglycerides

Butylene Glycol Dicaprylate/Dicaprate

Stearyl Heptanoate

Sodium Chloride

Jojoba Esters

Stearyl Caprylate

Helianthus Annuus Seed Wax

Menthyl PCA

Dipentaerythrityl Hexahydroxystearate/Hexastearate/Hexarosinate

Bis-Diglyceryl Polyacyladipate-2

Hydrolyzed Collagen

Ethylene/Propylene Copolymer

Trehalose

Betaine

Tocopheryl Acetate

Ethylhexylglycerin

Adenosine

Polyglycerin-3

Acacia Decurrens Flower Wax

Caffeine

Ectoin

Hydrogenated Polyisobutene

Hydrolyzed Elastin

Saccharomyces/Rice Ferment Filtrate

Hydroxypropyl Methylcellulose

Pullulan

Gardenia Florida Fruit Extract

Dextrin

Propanediol

Pentylene Glycol

Sodium Hyaluronate Crosspolymer

Polyglyceryl-10 Laurate

Porphyridium Cruentum Extract

Phenethyl Alcohol

Hydrolyzed Glycosaminoglycans

Fructan

Decyl Glucoside

Cynara Scolymus Leaf Extract

Sodium Hyaluronate

Hexyldecanol

Hydrolyzed Sponge

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Hydrogenated Lecithin

Ceramide NP

Benzyl Glycol

Glucose

Citric Acid

Hydrolyzed Hyaluronic Acid

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Caprylyl Glycol

Silica

Palmitoyl Tripeptide-5

Prunella Vulgaris Extract

Magnolia Officinalis Bark Extract

Xanthine

Anemarrhena Asphodeloides Root Extract

Tripeptide-1

Sodium Acetylated Hyaluronate

Palmitoyl Tripeptide-1

Palmitoyl Pentapeptide-4

Copper Tripeptide-1

Acetyl Hexapeptide-8

Calcium Silicate

Tocopherol

Hyaluronic Acid

Hexapeptide-9

Sodium Silicate

Nonapeptide-1

Parfum

Water, Dicaprylyl Carbonate, Butylene Glycol, Hydrogenated Poly(C6-14 Olefin), Ceresin, Synthetic Wax, Stearyl Dimethicone, C13-15 Alkane, Glycerin, Caprylic/Capric Triglyceride, Hdi/Trimethylol Hexyllactone Crosspolymer, Niacinamide, Dimethicone, Cetyl PEG/PPG-10/1 Dimethicone, Polymethyl Methacrylate, 1,2-Hexanediol, Sorbitan Olivate, C10-18 Triglycerides, Butylene Glycol Dicaprylate/Dicaprate, Stearyl Heptanoate, Sodium Chloride, Jojoba Esters, Stearyl Caprylate, Helianthus Annuus Seed Wax, Menthyl PCA, Dipentaerythrityl Hexahydroxystearate/Hexastearate/Hexarosinate, Bis-Diglyceryl Polyacyladipate-2, Hydrolyzed Collagen, Ethylene/Propylene Copolymer, Trehalose, Betaine, Tocopheryl Acetate, Ethylhexylglycerin, Adenosine, Polyglycerin-3, Acacia Decurrens Flower Wax, Caffeine, Ectoin, Hydrogenated Polyisobutene, Hydrolyzed Elastin, Saccharomyces/Rice Ferment Filtrate, Hydroxypropyl Methylcellulose, Pullulan, Gardenia Florida Fruit Extract, Dextrin, Propanediol, Pentylene Glycol, Sodium Hyaluronate Crosspolymer, Polyglyceryl-10 Laurate, Porphyridium Cruentum Extract, Phenethyl Alcohol, Hydrolyzed Glycosaminoglycans, Fructan, Decyl Glucoside, Cynara Scolymus Leaf Extract, Sodium Hyaluronate, Hexyldecanol, Hydrolyzed Sponge, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Hydrogenated Lecithin, Ceramide NP, Benzyl Glycol, Glucose, Citric Acid, Hydrolyzed Hyaluronic Acid, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Caprylyl Glycol, Silica, Palmitoyl Tripeptide-5, Prunella Vulgaris Extract, Magnolia Officinalis Bark Extract, Xanthine, Anemarrhena Asphodeloides Root Extract, Tripeptide-1, Sodium Acetylated Hyaluronate, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Copper Tripeptide-1, Acetyl Hexapeptide-8, Calcium Silicate, Tocopherol, Hyaluronic Acid, Hexapeptide-9, Sodium Silicate, Nonapeptide-1, Parfum

C12-15 Alkyl Benzoate

Cetearyl Alcohol

Cetyl Ethylhexanoate

Cyclohexasiloxane

Prunus Amygdalus Dulcis Oil

Butoxyethanol

Arginine

Carbomer

Glyceryl Stearate

Olea Europaea Fruit Oil

Polysorbate 60

Beeswax

PEG-100 Stearate

Sodium Polyacrylate

Palmitic Acid

Stearic Acid

Yeast

Anthemis Nobilis Flower Extract

Disodium EDTA

Malt Extract

Panthenol

Centella Asiatica Extract

Lavandula Angustifolia Extract

Water, Hydrolyzed Collagen, Glycerin, C12-15 Alkyl Benzoate, Cetearyl Alcohol, Cetyl Ethylhexanoate, Cyclohexasiloxane, 1,2-Hexanediol, Prunus Amygdalus Dulcis Oil, Butoxyethanol, Arginine, Carbomer, Dimethicone, Glyceryl Stearate, Olea Europaea Fruit Oil, Polysorbate 60, Beeswax, PEG-100 Stearate, Sodium Polyacrylate, Palmitic Acid, Stearic Acid, Parfum, Yeast, Hydrogenated Lecithin, Ethylhexylglycerin, Adenosine, Anthemis Nobilis Flower Extract, Disodium EDTA, Polyglyceryl-10 Laurate, Malt Extract, Pentylene Glycol, Panthenol, Hexyldecanol, Ceramide NP, Hydrolyzed Elastin, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Centella Asiatica Extract, Lavandula Angustifolia Extract

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

This small molecule peptide has similar benefits to Argireline, the "botox" peptide.

According to the manufacturer, this peptide mimics snake venom to freeze muscles. This prevents muscle movement and contractions to prohibit the formation of fine lines and wrinkles.

While this seems promising, research is lacking in proving this ingredient to be as effective as botox.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hexyldecanol is a fatty alcohol that is basically the "light" version of cetyl alcohol. It is an emollient and skin conditioning agent that leaves a silky feeling on skin without tackiness.

Because it is stable across a wide pH range, it plays nicely with most actives. Typical use concentrations range from 1-10% and it can be either plant derived or synthetically created.

Overall, this is a well-tolerated ingredient and only a few cases of contact dermatitis have been reported.

The closest tested cousin of this ingredient, Octyldodecanol, did not support Malassezia growth in vitro. The Malassezia yeast responsible for fungal acne prefers straight-chain substrates whereas Hexyldecanol and Octyldodecanol are branched. While this ingredient is unlikely to cause fungal acne, be sure to patch test if you're unsure.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.

In a formula, it works mainly as a skin-conditioning and moisturizing agent.

The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.

This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.

It's worth being realistic here:

Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals).

However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.

Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).

Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity.

If you are looking for vegan collagen, it usually goes by a different INCI name like hydrolyzed soy protein. Vegan collagen is derived from yeast, bacteria, or plant sources.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

We don't have a description for Hydrolyzed Elastin yet.

Palmitoyl Tripeptide-5 is a synthetic signal lipopeptide. This just means it is a three amino acid chain bolted onto a palmitic acid tail so it can slip through the skin's lipid barrier.

This peptide has a "build more, lose less" approach.

It's designed to mimic the collagen-stimulating activity in your skin by copying a snippet of one of your skin's own matrix proteins. This nudges fibroblasts into making more collagen while inhibiting the enzyme that breaks down skin protein.

The manufacturer's in vivo study of 45 volunteers found 1% and 2.5% reduced the appearance of wrinkles by 7% and 12% respectively, after using it twice daily for 84 days.

This is in the expected range for peptides; they're slow and cumulative actives and not overnight fixers.

Typical use levels range from 1-3% and this ingredient gets along with pretty much everything.

On the fungal acne front: Although palmitic acid sits in the chain length that Malassezia can feed on, this ingredient has it locked in an amine bond. This makes it hard for Malassezia to access as a source of food, and therefore fungal acne safe.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Polyglyceryl-10 Laurate is a cleansing agent and emulsifier.

It rounds up dirt, oil, and grime, so they can be rinsed off easily as a cleanser.

On the emulsifier side, it keeps your formula smooth and well-mixed by playing peacekeeper for ingredients that don't naturally get along (like oil and water).

Because it has a C12 (lauric acid) fatty acid chain, this ingredient can potentially feed the Malassezia yeast that causes fungal acne. The Malassezia yeast prefers esters with C11-C24 fatty acids.

This ingredient is an ester of lauric acid and Polyglycerin-10.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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