liquiclomi 50mg / ml | 60ml

1. Acromegaly

Acromegaly is a disorder that causes enlargement of the body tissues and organs, such as hands and feet. It is caused by excessive production of growth hormones. Studies indicate that estrogen therapy can show positive results in women with acromegaly. On the other side, SERMs have been shown to treat this disorder in both men and women.

One study was designed to look at the effect of clomiphene citrate on serum IGF-1 and testosterone in men with uncontrolled acromegaly. Six male patients were enrolled in the study and asked to add clomid to their treatment. The researchers observed that treatment successfully enhanced testosterone levels by up to 209% and caused a reduction in IGF-1 levels by 44 %, suggesting the potential of clomiphene to treat acromegaly in men not responding to other therapies [2].

2. Short-lasting Unilateral Neuralgiform Headache Attacks (SUNCT) syndrome

SUNCT is a type of headache disorder characterized by sudden, severe, short-lasting and frequent attacks of pain on the one side of the head. It manifests autonomic symptoms, such as eyelid edema, conjunctivitis injection and nasal congestion. Research shows that clomiphene citrate might prevent or even treat SUNCT. A case report of a patient diagnosed with SUNCT, who was unresponsive to traditional treatment options, reported that clomiphene therapy completely resolved the frequent attacks [3].

3. Infertility

Clomiphene is utilized to induce ovulation in women experiencing irregular ovulation due to conditions like polycystic ovary syndrome (PCOS) or anovulation. It may be prescribed alone or in combination with metformin or other insulin sensitizers.

A comparative study investigated the effectiveness of clomiphene and metformin in women with PCOS. The study involved 626 infertile women with PCOS who were randomly assigned to receive either clomiphene, metformin, or a combination of both. The findings revealed live birth rates of 22.5%, 7.5%, and 26.8% in the clomiphene, metformin, and combination therapy groups, respectively. The study concluded that clomiphene demonstrated superior efficacy compared to metformin [4].

Many patients with PCOS develop resistance to the use of clomiphene citrate. The combination of letrozole and metformin has been shown to be effective for such candidates [5]. Research suggests that letrozole is associated with higher live birth rates and improved ovulation outcomes compared to clomiphene [6]. Additionally, clomiphene has been shown to improve male infertility. Studies indicate that it can enhance sperm production and motility, serving as a safe therapy to improve sperm parameters in infertile men [7].

4. Secondary Hypogonadism

Secondary hypogonadism is a condition in which the testes receive inadequate stimulation from the hypothalamus and pituitary glands. These results in the reduced production of sex hormones and the appearance of symptoms, such as muscle weakness, low libido and erectile dysfunction.

Testosterone replacement therapy (TRT) is used for the treatment of secondary hypogonadism. However, it causes an increase in hematocrit levels and prostate-specific antigen (PSA), limiting its long-term utilization. On the other hand, clomifene has been shown to treat secondary hypogonadism. It stimulates the release of GnRH [8]. One study found that clomiphene can improve testosterone levels by 53.2% as compared to TRT (46.8%) [9].