Liberty Blue 2.0 - Microwave Peptide Synthesizer

Liberty Blue 2.0

Microwave Peptide Synthesizer

Liberty Blue 2.0

Synthesize peptides efficiently for research and development.

The Liberty Blue™ 2.0 is an ultra-efficient microwave peptide synthesizer, delivering high-quality peptides with record low waste generation and synthesis times. Through partnering CEM's patented and published No-Wash methodology with flexible and intuitive system controls, the Liberty Blue 2.0 opens up a world of more efficient, high-yielding, and structurally complex syntheses than ever thought possible.

• <4 minutes per amino acid (AA) addition (includes coupling through deprotection, scales under 0.5 mmol)
• <6 mL waste generated per AA addition (includes coupling through deprotection, scales under 0.2 mmol )
• 0.005 to 5 mmol synthesis scale range
• HT accessories available for queueing up to 12 syntheses
• 21CFR Part 11 compliant software

Ultra Efficient - Solid Phase Peptide Synthesis (UE-SPPS)

New "No Wash" approach, same clean peptides.

With this Liberty system comes the revolutionary UE-SPPS methodology; total wash elimination. Through a remarkable combination of methodology optimization, reagent selection, and engineering advancements, CEM's "No Wash" technology reduces waste production by up to 95%, and all without sacrificing synthesis yield and purity.

Learn more about UE-SPPS

Semaglutide (Crude)

Length: 31 Amino Acids
Scale: 0.1 mmol
Synthesis Time: ~ 1 hour, 50 minutes
Waste: 135 mL (Liberty PRIME 2.0) or 238 mL (Liberty Blue 2.0)

1-42β-amyloid (Crude)

Length: 42 Amino Acids
Scale: 0.1 mmol
Synthesis Time: ~ 2 hours, 30 minutes
Waste: 179 mL (Liberty PRIME 2.0) or 316 mL (Liberty Blue 2.0)

Proinsulin (Crude)

Length: 86 Amino Acids
Scale: 0.1 mmol
Synthesis Time: ~ 10 hours, 40 minutes
Waste: 687 mL (Liberty PRIME 2.0) or 973 mL (Liberty Blue 2.0)

Unmatched Peptide Quality

A new level of peptide purity.

With advancements in system fluidics, reaction vessel environment, and chemistry methodology achieve better synthesis results than ever before.

Better Chemistry

• Carbodiimide coupling strategy for reduced epimerization and side reactions
• ProTide resin development for optimized loading and swelling parameters
• Microwave heating approach for improved reaction efficiency and synthesis results

Better Engineering

• Headspace flushing technology for cleaner reaction environment
• Optimized flow paths for simple and efficient reagent delivery
• Digitally variable N₂ control for enhanced bubbling, purging, and draining

Accurate Reagent Delivery

The best way to deliver critical reagents.

Flex-Add™ Technology

• No volume constraints for infinitely variable delivery quantities, unlike sample loops
• Never prime - avoid unnecessary consumption of expensive and precious reagents
• No washing for elegant flow path design eliminates waste from background cleaning steps

High Throughput (HT) Loaders

More peptide synthesis, less hands-on time.

Queue up to 4 sequential syntheses with the optional HT4 accessory, and up to 12 sequential syntheses with the HT12 accessory.

Each peptide is available immediately, eliminating purification bottlenecks common with batch syntheses.

View Application Data

Software

Flexible, Powerful, Traceable

Enter the Parameters

The method editor on the Liberty Blue allows full customization of reaction parameters.

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Pause, Edit, Monitor at any Step

Easily pause, edit, and monitor reactions from the run screen.

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Specialty Applications

Non-standard peptides? No problem.

• Branched Peptides
• Disulfide Bonding Peptoids
• High Throughput Synthesis
• Phosphopeptides
• Proteins
• Cyclized Peptides
• Glycopeptides (N/O-linked)
• N-Methyl Peptides
• PNAS
• Stapled Peptides

View all application notes

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