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Lancôme Rénergie Multi-Glow Cream Versus Estée Lauder Advanced Night Repair Overnight Treatment

Lancôme Rénergie Multi-Glow Cream Versus Estée Lauder Advanced Night Repair Overnight Treatment This anti-aging day moisturizer is formulated around Adenosine to soften the look of wrinkles. This barrier-repair night moisturizer is formulated around Butyrosper

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Lancôme Rénergie Multi-Glow Cream Versus Estée Lauder Advanced Night Repair Overnight Treatment

This anti-aging day moisturizer is formulated around Adenosine to soften the look of wrinkles.

This barrier-repair night moisturizer is formulated around Butyrospermum Parkii Butter and Sodium Hyaluronate to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Cyclohexasiloxane

Glycerin

Cetyl Alcohol

Butyrospermum Parkii Butter

Hydrogenated Polyisobutene

Glyceryl Stearate

Octyldodecanol

PEG-40 Stearate

Myristyl Myristate

Titanium Dioxide

Iron Oxides

CI 77163

Bixa Orellana Seed Oil

Guanosine

Cyathea Medullaris Leaf Extract

Zea Mays Starch

Tocopherol

Mica

Hydrolyzed Linseed Extract

Hydroxypropyl Starch Phosphate

Sodium Hydroxide

Sodium Benzoate

Hydrogenated Lecithin

Sodium Levulinate

Phenoxyethanol

Adenosine

Schizandra Sphenanthera Fruit Extract

Chlorphenesin

Polysorbate 80

Maltodextrin

Polyvinyl Alcohol

Helianthus Annuus Seed Oil

Limonene

Synthetic Fluorphlogopite

Mannitol

Benzyl Alcohol

Tin Oxide

Linalool

Xanthan Gum

Cinnamic Acid

Isohexadecane

Isobutane

Capryloyl Salicylic Acid

Caprylyl Glycol

Sorbitan Tristearate

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer

Sorbitan Oleate

Geraniol

Disodium EDTA

Citronellol

Citric Acid

Levulinic Acid

Glyceryl Caprylate

Parfum

Water, Cyclohexasiloxane, Glycerin, Cetyl Alcohol, Butyrospermum Parkii Butter, Hydrogenated Polyisobutene, Glyceryl Stearate, Octyldodecanol, PEG-40 Stearate, Myristyl Myristate, Titanium Dioxide, Iron Oxides, CI 77163, Bixa Orellana Seed Oil, Guanosine, Cyathea Medullaris Leaf Extract, Zea Mays Starch, Tocopherol, Mica, Hydrolyzed Linseed Extract, Hydroxypropyl Starch Phosphate, Sodium Hydroxide, Sodium Benzoate, Hydrogenated Lecithin, Sodium Levulinate, Phenoxyethanol, Adenosine, Schizandra Sphenanthera Fruit Extract, Chlorphenesin, Polysorbate 80, Maltodextrin, Polyvinyl Alcohol, Helianthus Annuus Seed Oil, Limonene, Synthetic Fluorphlogopite, Mannitol, Benzyl Alcohol, Tin Oxide, Linalool, Xanthan Gum, Cinnamic Acid, Isohexadecane, Isobutane, Capryloyl Salicylic Acid, Caprylyl Glycol, Sorbitan Tristearate, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer, Sorbitan Oleate, Geraniol, Disodium EDTA, Citronellol, Citric Acid, Levulinic Acid, Glyceryl Caprylate, Parfum

Theobroma Cacao Seed Butter

Coco-Caprylate/Caprate

Caprylic/Capric/Myristic/Stearic Triglyceride

Butylene Glycol

C9-12 Alkane

Dimethicone

Cetearyl Alcohol

PEG-100 Stearate

Tripeptide-32

Sodium Hyaluronate

Sodium Polyglutamate

Succinic Acid

Artemia Extract

Squalane

Lactobacillus Ferment

Tocopheryl Acetate

Caffeine

Algae Extract

Lavandula Angustifolia Flower Extract

Hydrolyzed Rice Extract

Faex Extract

Hordeum Vulgare Extract

Anthemis Nobilis Flower Extract

Cucumis Sativus Fruit Extract

Helianthus Annuus Seed Extract

Sorbitol

Potassium Palmitoyl Hydrolyzed Wheat Protein

Propylene Glycol Dicaprate

Steareth-21

Dimethicone Crosspolymer-3

Steareth-2

Hexylene Glycol

Ethylhexylglycerin

Glucose

BHT

Sodium Dehydroacetate

Potassium Sorbate

CI 19140

CI 14700

Water, Butyrospermum Parkii Butter, Theobroma Cacao Seed Butter, Coco-Caprylate/Caprate, Caprylic/Capric/Myristic/Stearic Triglyceride, Butylene Glycol, Glyceryl Stearate, Cetyl Alcohol, Glycerin, C9-12 Alkane, Dimethicone, Cetearyl Alcohol, PEG-100 Stearate, Tripeptide-32, Sodium Hyaluronate, Sodium Polyglutamate, Succinic Acid, Artemia Extract, Squalane, Lactobacillus Ferment, Tocopheryl Acetate, Caffeine, Algae Extract, Lavandula Angustifolia Flower Extract, Hydrolyzed Rice Extract, Faex Extract, Hordeum Vulgare Extract, Anthemis Nobilis Flower Extract, Cucumis Sativus Fruit Extract, Helianthus Annuus Seed Extract, Sorbitol, Potassium Palmitoyl Hydrolyzed Wheat Protein, Propylene Glycol Dicaprate, Maltodextrin, Steareth-21, Dimethicone Crosspolymer-3, Steareth-2, Hexylene Glycol, Xanthan Gum, Caprylyl Glycol, Ethylhexylglycerin, Glucose, BHT, Disodium EDTA, Phenoxyethanol, Sodium Dehydroacetate, Potassium Sorbate, CI 19140, CI 14700

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Cetyl Alcohol is a fatty alcohol. Fatty Alcohols are most often used as an emollient or to thicken a product.

Its main roles are:

Though it has "alcohol" in the name, it is not related to denatured alcohol or ethyl alcohol.

The FDA allows products labeled "alcohol-free" to have fatty alcohols.

This ingredient may not be fungal acne safe. It is a primary fatty alcohol with a chain length above 12 carbons. A study from 2019 show Malassezia can feed on fatty alcohols in this range, so it may trigger fungal acne in those prone to it.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glyceryl Stearate is made by reacting glycerin with stearic acid (typically sourced from plant oils like palm or coconut). It's an emulsifier, emollient, and mild occlusive.

Emulsifiers help ingredients like oil and water stay mixed so your formula stays nicely blended and uniform in texture.

This ingredient is typically used in concentrations between 1-10%. Studies have found it to be non-sensitizing, non-phototoxic, and non-photoallergenic.

A close cousin of this ingredient is Glyceryl Stearate SE ("self-emulsifying"). This just has a small amount of sodium or potassium stearate added so it can emulsify without a co-emulsifier.

Since this ingredient is an ester of a C18 fatty acid, it may not be fungal acne safe. The Malassezia yeast can potentially metabolize within the C11-C24 range.

Fun fact: The human body also creates Glyceryl Stearate naturally.

Maltodextrin is a plant-derived carbohydrate made by breaking down starch (usually from corn, potato, or rice). In cosmetic formulas, it's a multitasking absorbent, emulsion stabilizer, and skin conditioner.

This ingredient is mostly used to stabilize emulsions and improve the powdery, non-greasy feel of products (like dry shampoos).

Safety-wise, this ingredient is pretty solid; it's even recognized as a food additive. Both animal and clinical studies found no adverse effects at the levels used in cosmetics.

Industry data shows this ingredient is used up to 45.7% in spray products and up to 33% in powder products.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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