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L'Oreal Age Perfect Cell Renewal Antioxidant Midnight Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

L'Oreal Age Perfect Cell Renewal Antioxidant Midnight Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum This serum is formulated around Saccharomyces/Xylinum/Black Tea Ferment and Capryloyl Salicylic Acid to calm irritat

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

L'Oreal Age Perfect Cell Renewal Antioxidant Midnight Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

This serum is formulated around Saccharomyces/Xylinum/Black Tea Ferment and Capryloyl Salicylic Acid to calm irritation and control oil.

This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Glycerin

Alcohol Denat.

PEG-8

Dipropylene Glycol

Saccharomyces/Xylinum/Black Tea Ferment

Propylene Glycol

Polysilicone-11

Bis-PEG-18 Methyl Ether Dimethyl Silane

Tuber Aestivum Extract

Tuber Melanosporum Extract

Adenosine

Capryloyl Salicylic Acid

Neohesperidin Dihydrochalcone

Sodium Hyaluronate

Trisodium Ethylenediamine Disuccinate

Tocopherol

Octyldodecanol

Squalane

Ammonium Polyacryloyldimethyl Taurate

Biosaccharide Gum-4

Biotin

Caprylyl Glycol

Citric Acid

Hydroxyethylcellulose

PEG-20 Methyl Glucose Sesquistearate

Sodium Citrate

Xanthan Gum

Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone

Caprylic/Capric Triglyceride

Benzyl Alcohol

Hexyl Cinnamal

Hydroxycitronellal

CI 14700

CI 19140

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Phenoxyethanol

Potassium Sorbate

Sodium Benzoate

Sodium Salicylate

Parfum

Water, Dimethicone, Glycerin, Alcohol Denat., PEG-8, Dipropylene Glycol, Saccharomyces/Xylinum/Black Tea Ferment, Propylene Glycol, Polysilicone-11, Bis-PEG-18 Methyl Ether Dimethyl Silane, Tuber Aestivum Extract, Tuber Melanosporum Extract, Adenosine, Capryloyl Salicylic Acid, Neohesperidin Dihydrochalcone, Sodium Hyaluronate, Trisodium Ethylenediamine Disuccinate, Tocopherol, Octyldodecanol, Squalane, Ammonium Polyacryloyldimethyl Taurate, Biosaccharide Gum-4, Biotin, Caprylyl Glycol, Citric Acid, Hydroxyethylcellulose, PEG-20 Methyl Glucose Sesquistearate, Sodium Citrate, Xanthan Gum, Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone, Caprylic/Capric Triglyceride, Benzyl Alcohol, Hexyl Cinnamal, Hydroxycitronellal, CI 14700, CI 19140, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, Sodium Salicylate, Parfum

Bifida Ferment Lysate

Propanediol

Methyl Gluceth-20

Glycereth-26

PEG-75

Butylene Glycol

Adansonia Digitata Seed Extract

Tripeptide-32

Faex Extract

Lactobacillus Ferment

Cola Acuminata Seed Extract

Anthemis Nobilis Flower Extract

Hydrolyzed Algin

Pantethine

Caffeine

Lecithin

Sodium Rna

Bisabolol

Oleth-3 Phosphate

Oleth-3

Oleth-5

Choleth-24

Hydrogenated Lecithin

Jojoba Wax PEG-120 Esters

Ceteth-24

Tocopheryl Acetate

Carbomer

Triethanolamine

Tetrasodium EDTA

BHT

Disodium EDTA

Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Bis-Peg-18 Methyl Ether Dimethyl Silane belongs to the siloxanes and silicones classes. It is synthetically created and has a waxy composition.

This ingredient is a humectant and emollient, meaning it helps hydrate the skin. Humectants draw moisture to your skin, while emollients prevent moisture from escaping.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ci 14700, also known as Red No. 4, is a synthetic red dye derived from petroleum. It is water soluble.

CI 19140 is also known as Tartrazine. Tartrazine is a synthetic dye used in cosmetics, foods, and medicine to add a yellow color.

Tartrazine is created from petroleum and is water-soluble.

Some people may experience allergies from this dye, especially asthmatics and those with an aspirin intolerance.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

PEG-8 is a synthetic polymer used as a humectant and solvent.

This ingredient is able to help dissolve active ingredients, including water. This gives it humectant properties.

It is soluble in water. The number '8' stands for the molecular weight of the ingredient.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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