Educational guide
KORRES Black Pine Primus 6xHA Wrinkle Smoothing Youth Activator Booster Serum Versus Jorgobé Multi Peptide Lifting Filler
KORRES Black Pine Primus 6xHA Wrinkle Smoothing Youth Activator Booster Serum Versus Jorgobé Multi Peptide Lifting Filler This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Hydrolyzed Sodium Hyaluronate to soften the look of wrinkles and hydra
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KORRES Black Pine Primus 6xHA Wrinkle Smoothing Youth Activator Booster Serum Versus Jorgobé Multi Peptide Lifting Filler
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Hydrolyzed Sodium Hyaluronate to soften the look of wrinkles and hydrate skin.
This anti-aging serum is formulated around Palmitoyl Tripeptide-38 and Acetyl Hexapeptide-8 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Propanediol
Sodium Polyacryloyldimethyl Taurate
1,2-Hexanediol
Acetyl Hexapeptide-8
Alanine
Arginine
Avena Strigosa Seed Extract
Betaine
Caprylyl Glycol
Cellulase
Citric Acid
Dictyopteris Polypodioides Extract
Disodium Phosphate
Epigallocatechin Gallatyl Glucoside
Ethylhexylglycerin
Gallyl Glucoside
Glutamic Acid
Glycine
Hydrolyzed Sodium Hyaluronate
Hydrolyzed Soy Flour
Hydroxyacetophenone
Lactic Acid
Lecithin
Linolenic Acid
Lysine Hcl
Pancratium Maritimum Extract
PCA
Pentylene Glycol
Pinus Nigra Bud/Needle Extract
Proline
Propyl Gallate
Serine
Sodium Acetylated Hyaluronate
Sodium Carboxymethyl Beta-Glucan
Sodium Hyaluronate
Sodium Hyaluronate Crosspolymer
Sodium Lactate
Sodium PCA
Sodium Phosphate
Tetrasodium Glutamate Diacetate
Threonine
Benzyl Alcohol
Dehydroacetic Acid
Potassium Sorbate
Sodium Benzoate
Water, Glycerin, Propanediol, Sodium Polyacryloyldimethyl Taurate, 1,2-Hexanediol, Acetyl Hexapeptide-8, Alanine, Arginine, Avena Strigosa Seed Extract, Betaine, Caprylyl Glycol, Cellulase, Citric Acid, Dictyopteris Polypodioides Extract, Disodium Phosphate, Epigallocatechin Gallatyl Glucoside, Ethylhexylglycerin, Gallyl Glucoside, Glutamic Acid, Glycine, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Soy Flour, Hydroxyacetophenone, Lactic Acid, Lecithin, Linolenic Acid, Lysine Hcl, Pancratium Maritimum Extract, PCA, Pentylene Glycol, Pinus Nigra Bud/Needle Extract, Proline, Propyl Gallate, Serine, Sodium Acetylated Hyaluronate, Sodium Carboxymethyl Beta-Glucan, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Lactate, Sodium PCA, Sodium Phosphate, Tetrasodium Glutamate Diacetate, Threonine, Benzyl Alcohol, Dehydroacetic Acid, Potassium Sorbate, Sodium Benzoate
Coco-Caprylate/Caprate
Butyrospermum Parkii Butter
Sclerotium Gum
Ethylhexyl Stearate
Squalane
Glyceryl Stearate Citrate
Disodium Acetyl Glucosamine Phosphate
Palmitoyl Tripeptide-38
Dipotassium Glycyrrhizate
Glyceryl Caprylate
Hydrolyzed Jojoba Esters
Jojoba Esters
Hydroxypropyl Cyclodextrin
Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate
Sodium Isostearate
Sodium Gluconate
Water, Glycerin, Pentylene Glycol, Coco-Caprylate/Caprate, Butyrospermum Parkii Butter, Sclerotium Gum, Ethylhexyl Stearate, Sodium PCA, Squalane, Glyceryl Stearate Citrate, Disodium Acetyl Glucosamine Phosphate, Palmitoyl Tripeptide-38, Acetyl Hexapeptide-8, Sodium Hyaluronate Crosspolymer, Dipotassium Glycyrrhizate, Glyceryl Caprylate, Caprylyl Glycol, Hydrolyzed Jojoba Esters, Jojoba Esters, Ethylhexylglycerin, Hydroxypropyl Cyclodextrin, Polyglyceryl-4 Diisostearate/Polyhydroxystearate/Sebacate, Sodium Isostearate, Sodium Gluconate
Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.
Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.
Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).
Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:
The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.
Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:
Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.
On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.
Typical use levels in a formula run about 1-5%.
Sodium Hyaluronate Crosspolymer is a crosslinked version of sodium hyaluronate. This just means it's linked into a 3D mesh network that lets it be more stable and sit on skin as a cohesive, gel-like film rather than sinking into skin.
A 2016 human skin study found crosslinked HA increased epidermal water content by 7.6% over the control group and reduced transepidermal water loss by 27.8%.
A follow-up clinical trial found that a topical crosslinked HA serum applied after fillers, microneedling, or chemical peels was well-tolerated and enhanced skin quality at 14 / 28 days.
More recent research suggests that concentrations as low as 0.03% can act as a penetration enhancer for other skincare actives.
Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.
Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.
As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.
There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.
Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.
It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!