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hyphen Power Peptides Cocktail Serum Versus Akind On Cloud Nine Lightweight Moisturiser

hyphen Power Peptides Cocktail Serum Versus Akind On Cloud Nine Lightweight Moisturiser This anti-aging serum is formulated around Tripeptide-1 and Palmitoyl Pentapeptide-4 to soften the look of wrinkles and refine skin texture. This barrier-repair moisturizer

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

hyphen Power Peptides Cocktail Serum Versus Akind On Cloud Nine Lightweight Moisturiser

This anti-aging serum is formulated around Tripeptide-1 and Palmitoyl Pentapeptide-4 to soften the look of wrinkles and refine skin texture.

This barrier-repair moisturizer is formulated around Niacinamide to strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Propylene Glycol

Propanediol

Glycerin

Tripeptide-1

Hexapeptide-9

Palmitoyl Pentapeptide-4

Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-5

Palmitoyl Tetrapeptide-7

Butylene Glycol

Panax Ginseng Extract

Trehalose

Copper Tripeptide-1

Acetyl Hexapeptide-8

Caprylyl Glycol

Xylitylglucoside

Anhydroxylitol

Sodium Hyaluronate

Linum Usitatissimum Seed Extract

Panthenol

Saccharide Isomerate

Xanthan Gum

Carbomer

Polysorbate 20

Citric Acid

Sodium Citrate

Phenoxyethanol

Ethylhexylglycerin

Water, Propylene Glycol, Propanediol, Glycerin, Tripeptide-1, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Butylene Glycol, Panax Ginseng Extract, Trehalose, Copper Tripeptide-1, Acetyl Hexapeptide-8, Caprylyl Glycol, Xylitylglucoside, Anhydroxylitol, Sodium Hyaluronate, Linum Usitatissimum Seed Extract, Panthenol, Saccharide Isomerate, Xanthan Gum, Carbomer, Polysorbate 20, Citric Acid, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin

Heptyl Undecylenate

Isononyl Isononanoate

Peptide Complex

Sodium Acrylates Copolymer

Caprylic/Capric Triglyceride

Niacinamide

Ceramide Complex

Lecithin

Tocopheryl Acetate

Alpha-Glucan Oligosaccharide

Squalane

Disodium EDTA

Water, Heptyl Undecylenate, Isononyl Isononanoate, Peptide Complex, Sodium Acrylates Copolymer, Caprylic/Capric Triglyceride, Sodium Hyaluronate, Niacinamide, Copper Tripeptide-1, Ceramide Complex, Phenoxyethanol, Lecithin, Panthenol, Tocopheryl Acetate, Ethylhexylglycerin, Alpha-Glucan Oligosaccharide, Squalane, Disodium EDTA

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Panthenol is a common ingredient that helps hydrate and soothe the skin. It is found naturally in our skin and hair.

There are two forms of panthenol: D and L.

D-panthenol is also known as dexpanthenol. Most cosmetics use dexpanthenol or a mixture of D and L-panthenol.

Panthenol is famous due to its ability to go deeper into the skin's layers. Using this ingredient has numerous pros (and no cons):

Like hyaluronic acid, panthenol is a humectant. Humectants are able to bind and hold large amounts of water to keep skin hydrated.

This ingredient works well for wound healing. It works by increasing tissue in the wound and helps close open wounds.

Once oxidized, panthenol converts to pantothenic acid. Panthothenic acid is found in all living cells.

This ingredient is also referred to as pro-vitamin B5.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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