Educational guide
FOXO4-DRI Dosage Protocol | PeptideDosages.com
FOXO4-DRI (10 mg Vial) Dosage Protocol FOXO4-DRI Dosage Chart FOXO4-DRI is dosed at 250 mcg–500 mcg daily via subcutaneous injection in educational protocols. A 10 mg vial reconstituted with bacteriostatic water yields about 3.33 mg/mL. This information is for
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FOXO4-DRI (10 mg Vial) Dosage Protocol
FOXO4-DRI Dosage Chart
FOXO4-DRI is dosed at 250 mcg–500 mcg daily via subcutaneous injection in educational protocols. A 10 mg vial reconstituted with bacteriostatic water yields about 3.33 mg/mL. This information is for research and educational use only.
Reconstitute: Add 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration.
Typical daily range: 250–500 mcg once daily (gradual titration over 16 weeks).
Easy measuring: At 3.33 mg/mL, 1 unit = 0.01 mL ≈ 33.3 mcg on a U-100 insulin syringe.
Storage: Lyophilized: freeze at −20 °C (−4 °F); after reconstitution, refrigerate at 2–8 °C (35.6–46.4 °F); avoid freeze–thaw cycles[8].
FOXO4-DRI (also known as Proxofim) is a synthetic D-retro-inverso peptide designed to selectively induce apoptosis in senescent cells by disrupting the FOXO4–p53 protein interaction[1][2]. When this interaction is blocked, p53 translocates to the mitochondria in senescent cells, triggering their programmed death while sparing healthy cells[1]. This educational protocol presents a once-daily subcutaneous approach using a practical dilution for precise insulin-syringe measurements.
Related research: For distinct compound, component, or formulation evidence and safety context, read NAD+ Peptide: Benefits, Uses, Side Effects, Dosage, and Research. These links are comparisons only; the compounds and formulations should not be treated as interchangeable.
Standard / Gradual Approach (3 mL = ~3.33 mg/mL)
Weeks 1–4
250 mcg
7.5 units (0.075 mL)
Weeks 5–8
375 mcg
11 units (0.11 mL)
Weeks 9–12
500 mcg
15 units (0.15 mL)
Weeks 13–16
Frequency: Inject once daily subcutaneously[7]. This schedule uses the standard 3.0 mL dilution to maintain injection volumes under 0.2 mL for all doses. For ≤10-unit (≤0.10 mL) administrations, consider 30- or 50-unit insulin syringes for improved readability.
Reconstitution Steps
Draw 3.0 mL bacteriostatic water with a sterile syringe.
Inject slowly down the vial wall; avoid foaming.
Gently swirl/roll until dissolved (do not shake)[8].
Label and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light.
Supplies Needed
Plan based on an 8–16 week daily protocol with gradual titration.
Peptide Vials (FOXO4-DRI, 10 mg each):
8 weeks ≈ 3 vials
12 weeks ≈ 4 vials
16 weeks ≈ 5 vials
Insulin Syringes (U-100):
Per week: 7 syringes (1/day)
8 weeks: 56 syringes
12 weeks: 84 syringes
16 weeks: 112 syringes
Bacteriostatic Water (10 mL bottles): Use ~3.0 mL per vial for reconstitution.
8 weeks (3 vials): 9 mL → 1 × 10 mL bottle
12 weeks (4 vials): 12 mL → 2 × 10 mL bottles
16 weeks (5 vials): 15 mL → 2 × 10 mL bottles
Alcohol Swabs: One for the vial stopper + one for the injection site each day.
Per week: 14 swabs (2/day)
8 weeks: 112 swabs → recommend 2 × 100-count boxes
12 weeks: 168 swabs → recommend 2 × 100-count boxes
16 weeks: 224 swabs → recommend 3 × 100-count boxes