Educational guide
Feasibility of β-Sheet Breaker Peptide-H102 Treatment ...
< Back to Article Figure 1. Paths and performance of mice in the probe trial. A : Escape latency in the three groups from day 1 to 5. (Day 2: * P <0.05; Days 3, 4, 5: ** P <0.01). B : The photographs, from the image capture system of Morris water maze, reflect
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Figure 1.
Paths and performance of mice in the probe trial.
A: Escape latency in the three groups from day 1 to 5. (Day 2: *P<0.05; Days 3, 4, 5: **P<0.01). B: The photographs, from the image capture system of Morris water maze, reflected the escape-latency of APP mice. C: Swimming time in the target quadrant. (**P<0.01, ▵▵P<0.01) D: Original angle. (**P<0.01, ▵▵P<0.01) E: The photographs, from the image capture system of Morris water maze, recorded spatial probe process of APP mice. Error bars represent mean ± SEM. Statistical analysis was performed using repeated measures ANOVA and Student-Newman-Keuls test.
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Expression of inflammatory factors (iNOS, IL-1β and TNF-α) in hippocampal CA1 area.
a: control group; b: model group; c: H102 group. 1: iNOS; 2: IL-1β; 3: TNF-α, (magnification ×400). A: The expression of inflammatory factors stained by IHC. B, C: Mean intensity of inflammatory factors and positive area of inflammatory factors. (**P<0.01, ▵▵P<0.01) D, E: The expression of iNOS, IL-1β and TNF-α by Western blotting (▵▵P<0.01). Error bars represent mean ± SEM. Statistical analysis was performed using one-way ANOVA following Student-Newman-Keuls test.
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Expression of P-tau, GSK-3 and PP-2A in cerebral cortex and hippocampal area.
a: cerebral cortex; b: hippocampal area. 1: control group; 2: model group; 3: H102 group, (magnification ×400). A: Expression of P-tau stained by IHC. B, C: Mean intensity of P-tau and positive area of P-tau. Content of P-tau (**P<0.01, ▵▵P<0.01) D: Expression of GSK-3 stained by IHC. E, F: Mean intensity of GSK-3 and positive area of GSK-3. (**P<0.01). G: Expression of PP-2A stained by IHC. H, I: Mean intensity of PP-2A and positive area of PP-2A. (**P<0.01). J, K: Expression of P-tau and expression of PP-2A by western blotting (<0.01, <0.01). Error bars represent mean ± SEM. Statistical analysis was performed using one-way ANOVA following Student-Newman-Keuls test.
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Expression of Bcl-2 and Bax in cerebral cortex and hippocampal area.
a: cerebral cortex; b: hippocampal. 1: control group; 2: model group; 3: H102 group (magnification ×400). A: Expression of Bax stained by IHC. B, C: Mean intensity of Bax and positive area of Bax. (**P<0.01, ▵▵P<0.01). D: Expression of Bcl-2 stained by IHC. E, F: Mean intensity of Bcl-2 and positive area of Bcl-2 (**P<0.01). G: The ratio of Bcl-2/Bax (<0.01). H, I: Expression of Bcl-2 and Bax by Western blotting (<0.01). Error bars represent mean ± SEM. Statistical analysis was performed using one-way ANOVA following Student-Newman-Keuls test.
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