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Estée Lauder Revitalizing Supreme + Night Versus Biossance Squalane + Omega Repair Cream

Estée Lauder Revitalizing Supreme + Night Versus Biossance Squalane + Omega Repair Cream This anti-aging night moisturizer is formulated around Niacinamide and Moringa Oleifera Seed Extract to soften the look of wrinkles and hydrate skin. This barrier-repair m

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Estée Lauder Revitalizing Supreme + Night Versus Biossance Squalane + Omega Repair Cream

This anti-aging night moisturizer is formulated around Niacinamide and Moringa Oleifera Seed Extract to soften the look of wrinkles and hydrate skin.

This barrier-repair moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycine Soja Oil

Caprylic/Capric/Myristic/Stearic Triglyceride

Glycerin

Prunus Amygdalus Dulcis Oil

Dimethicone

Stearyl Alcohol

Butylene Glycol

Steareth-2

Cocos Nucifera Oil

Vitis Vinifera Seed Oil

Glyceryl Stearate

Niacinamide

Propanediol

Steareth-21

Moringa Oleifera Seed Extract

Limonium Vulgare Flower/Leaf/Stem Extract

Sodium Hyaluronate

Acetyl Hexapeptide-8

Laminaria Digitata Extract

Whey Protein

Acetyl Glucosamine

Opuntia Tuna Fruit Extract

Tocopheryl Acetate

Citrullus Lanatus Fruit Extract

Persea Gratissima Oil

Mangifera Indica Seed Oil

Aminopropyl Ascorbyl Phosphate

Algae Extract

Caffeine

Cucumis Sativus Fruit Extract

Pyrus Malus Fruit Extract

Narcissus Tazetta Bulb Extract

Sigesbeckia Orientalis Extract

Butyrospermum Parkii Butter

Lens Esculenta Fruit Extract

Silybum Marianum Seed Oil

Limnanthes Alba Seed Oil

Hordeum Vulgare Extract

Simmondsia Chinensis Seed Oil

Macadamia Integrifolia Seed Oil

Olea Europaea Fruit Oil

Dextrin Palmitate

Sodium Hydroxide

Carbomer

Behenyl Alcohol

Caprylyl Glycol

Hydroxyethyl Urea

Propylene Glycol Dicaprate

Cholesterol

Isoceteth-20

Lactoperoxidase

Helianthus Annuus Seedcake

Sodium Polyaspartate

Sorbitol

Glucose

Cetyl Alcohol

Myristyl Alcohol

Sodium Lactate

Citric Acid

Sodium PCA

Glucose Oxidase

Potassium Phosphate

Sodium Chloride

Parfum

Disodium EDTA

BHT

Potassium Sorbate

Sodium Benzoate

Phenoxyethanol

CI 19140

CI 14700

CI 77491

CI 77492

Water, Glycine Soja Oil, Caprylic/Capric/Myristic/Stearic Triglyceride, Glycerin, Prunus Amygdalus Dulcis Oil, Dimethicone, Stearyl Alcohol, Butylene Glycol, Steareth-2, Cocos Nucifera Oil, Vitis Vinifera Seed Oil, Glyceryl Stearate, Niacinamide, Propanediol, Steareth-21, Moringa Oleifera Seed Extract, Limonium Vulgare Flower/Leaf/Stem Extract, Sodium Hyaluronate, Acetyl Hexapeptide-8, Laminaria Digitata Extract, Whey Protein, Acetyl Glucosamine, Opuntia Tuna Fruit Extract, Tocopheryl Acetate, Citrullus Lanatus Fruit Extract, Persea Gratissima Oil, Mangifera Indica Seed Oil, Aminopropyl Ascorbyl Phosphate, Algae Extract, Caffeine, Cucumis Sativus Fruit Extract, Pyrus Malus Fruit Extract, Narcissus Tazetta Bulb Extract, Sigesbeckia Orientalis Extract, Butyrospermum Parkii Butter, Lens Esculenta Fruit Extract, Silybum Marianum Seed Oil, Limnanthes Alba Seed Oil, Hordeum Vulgare Extract, Simmondsia Chinensis Seed Oil, Macadamia Integrifolia Seed Oil, Olea Europaea Fruit Oil, Dextrin Palmitate, Sodium Hydroxide, Carbomer, Behenyl Alcohol, Caprylyl Glycol, Hydroxyethyl Urea, Propylene Glycol Dicaprate, Cholesterol, Isoceteth-20, Lactoperoxidase, Helianthus Annuus Seedcake, Sodium Polyaspartate, Sorbitol, Glucose, Cetyl Alcohol, Myristyl Alcohol, Sodium Lactate, Citric Acid, Sodium PCA, Glucose Oxidase, Potassium Phosphate, Sodium Chloride, Parfum, Disodium EDTA, BHT, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol, CI 19140, CI 14700, CI 77491, CI 77492

Squalane

Caprylic/Capric Triglyceride

Isoamyl Laurate

Sorbitan Olivate

Cetearyl Olivate

Ceramide NP

Jojoba Esters

Euterpe Oleracea Sterols

Linoleic Acid

Oleic Acid

Linolenic Acid

Ethyl Linoleate

Tocopherol

Isoamyl Cocoate

Cetyl Palmitate

Sorbitan Palmitate

Cetearyl Alcohol

Ethylhexylglycerin

Sodium Gluconate

Water, Squalane, Glycerin, Caprylic/Capric Triglyceride, Isoamyl Laurate, Butyrospermum Parkii Butter, Sorbitan Olivate, Cetearyl Olivate, Ceramide NP, Jojoba Esters, Sodium Hyaluronate, Euterpe Oleracea Sterols, Linoleic Acid, Oleic Acid, Linolenic Acid, Ethyl Linoleate, Tocopherol, Isoamyl Cocoate, Cetyl Palmitate, Sorbitan Palmitate, Cetearyl Alcohol, Ethylhexylglycerin, Carbomer, Sodium Hydroxide, Phenoxyethanol, Sodium Gluconate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Hydroxide is also known as lye or caustic soda. It is used to adjust the pH of products; many ingredients require a specific pH to be effective.

In small amounts, sodium hydroxide is considered safe to use. However, large amounts may cause chemical burns due to its high alkaline.

Your skin has a natural pH and acid mantle. This acid mantle helps prevent harmful bacteria from breaking through. The acid mantle also helps keep your skin hydrated.

"Alkaline" refers to a high pH level. A low pH level would be considered acidic.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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