Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream Versus Clinique All About Eyes

Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream Versus Clinique All About Eyes This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles. This eye mo

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream Versus Clinique All About Eyes

This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles.

This eye moisturizer is formulated around Caffeine and Phytosphingosine to hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Methyl Trimethicone

Bifida Ferment Lysate

Dimethicone/Vinyl Dimethicone Crosspolymer

Propanediol

Petrolatum

Sucrose

Glycerin

Butylene Glycol

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Trehalose

Tripeptide-32

Adansonia Digitata Seed Extract

Lavandula Angustifolia Flower Extract

Sodium Hyaluronate

Lactobacillus Ferment

Tocopheryl Acetate

Faex Extract

Hypnea Musciformis Extract

Sodium Rna

Caffeine

Squalane

Anthemis Nobilis Flower Oil

Poria Cocos Sclerotium Extract

Citrullus Lanatus Fruit Extract

Lens Esculenta Fruit Extract

Pyrus Malus Fruit Extract

Ethylhexylglycerin

Sodium PCA

Phytosphingosine

Hydrolyzed Algin

Hordeum Distichon Extract

Jojoba Esters

Triticum Vulgare Germ Oil

Hydrogenated Lecithin

Lecithin

Isohexadecane

Jojoba Alcohol

Isopropyl Jojobate

PEG/PPG-18/18 Dimethicone

Polysorbate 80

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Sorbitan Oleate

Sodium Lactate

Polysorbate 40

Potassium Gluconate

Tocopherol

BHT

Phenoxyethanol

Potassium Sorbate

Sodium Benzoate

CI 77491

CI 77492

Water, Dimethicone, Methyl Trimethicone, Bifida Ferment Lysate, Dimethicone/Vinyl Dimethicone Crosspolymer, Propanediol, Petrolatum, Sucrose, Glycerin, Butylene Glycol, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Trehalose, Tripeptide-32, Adansonia Digitata Seed Extract, Lavandula Angustifolia Flower Extract, Sodium Hyaluronate, Lactobacillus Ferment, Tocopheryl Acetate, Faex Extract, Hypnea Musciformis Extract, Sodium Rna, Caffeine, Squalane, Anthemis Nobilis Flower Oil, Poria Cocos Sclerotium Extract, Citrullus Lanatus Fruit Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Ethylhexylglycerin, Sodium PCA, Phytosphingosine, Hydrolyzed Algin, Hordeum Distichon Extract, Jojoba Esters, Triticum Vulgare Germ Oil, Hydrogenated Lecithin, Lecithin, Isohexadecane, Jojoba Alcohol, Isopropyl Jojobate, PEG/PPG-18/18 Dimethicone, Polysorbate 80, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Sorbitan Oleate, Sodium Lactate, Polysorbate 40, Potassium Gluconate, Tocopherol, BHT, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, CI 77491, CI 77492

Cyclopentasiloxane

Isostearyl Palmitate

Polyethylene

Polysilicone-11

Ethylene/Acrylic Acid Copolymer

Morus Bombycis Root Extract

Triticum Vulgare Bran Extract

Scutellaria Baicalensis Root Extract

Whey Protein

Olea Europaea Fruit Extract

Camellia Sinensis Leaf Extract

Cholesterol

Linoleic Acid

Magnesium Ascorbyl Phosphate

Pyridoxine Dipalmitate

Glyceryl Laurate

Cetyl PEG/PPG-10/1 Dimethicone

Propylene Carbonate

Sodium Chloride

Quaternium-90 Bentonite

Disodium EDTA

CI 77499

Cyclopentasiloxane, Water, Isostearyl Palmitate, Polyethylene, Butylene Glycol, Polysilicone-11, Ethylene/Acrylic Acid Copolymer, Morus Bombycis Root Extract, Caffeine, Phytosphingosine, Triticum Vulgare Bran Extract, Scutellaria Baicalensis Root Extract, Whey Protein, Olea Europaea Fruit Extract, Camellia Sinensis Leaf Extract, Cholesterol, Linoleic Acid, Tocopheryl Acetate, Magnesium Ascorbyl Phosphate, Pyridoxine Dipalmitate, Sucrose, Glycerin, Dimethicone, Glyceryl Laurate, PEG/PPG-18/18 Dimethicone, Petrolatum, Cetyl PEG/PPG-10/1 Dimethicone, Propylene Carbonate, Sodium Chloride, Quaternium-90 Bentonite, Disodium EDTA, Phenoxyethanol, CI 77491, CI 77492, CI 77499

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Ci 77491 is also hydrated iron III oxide. It's sole purpose is to give a red/pink hue to products.

Iron III oxides are classified as inorganic chemicals for coloring.

Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

CI 77492 is also hydrated iron III oxide. It's sole purpose is to give a yellow hue to products.

Synthetically created CI 77492 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

PEG/PPG-18/18 Dimethicone is a modified version of dimethicone with emulsifying properties. It helps add a silky and lightweight feel to products like sunscreens and foundations.

Its unique structure allows it to bridge the gap between water-loving and oil-loving ingredients. This makes it especially good at creating stable, velvety, and elegant formulations.

Petrolatum is more commonly known as petroleum jelly. It is created by mixing waxes and mineral oils.

This ingredient is effective at reducing water loss by 99%. This is because it is an occlusive. Occlusives create a hydrophobic barrier on the skin to prevent evaporation. This property makes it great for hydrating dry skin.

Pro tip: Use occlusives, such as this ingredient, on damp skin for the best results.

The quality or origin of petrolatum is only known when disclosed by the brand. Most cosmetic petrolatum has gone through several purification stages.

Another benefit of occlusives is it protects your skin against infection or allergies.

Petrolatum is fungal acne safe. It is a hydrocarbon with no fatty acid structure, so Malassezia cannot metabolize it. In-vitro studies support negligible growth stimulation as well.

It's also worth noting that petrolatum has a comedogenic rating of 0. In updated rabbit ear testing (and in human testing), petrolatum was found to be not comedogenic. This means it didn’t promote comedone formation in standard models.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Phytosphingosine is a phospholipid naturally found in our skin as a building block for ceramides.. It helps moisturize, soothe, and protect skin.

Phytosphingosine contributes to your skin's natural moisturizing factor (NMF). The NMF is responsible for hydration, a strong barrier, and plasticity. Our NMF decreases with age. Increasing NMF leads to more healthy and hydrated skin.

Studies show products formulated with NMF ingredients help strengthen our skin's barrier. Having a healthy skin barrier reduces irritation and increases hydration. Our skin barrier is responsible for having plump and firm skin. It also helps protect our skin against infection, allergies, and inflammation.

Fun fact: Phytosphingosine is abundant in plants and fungi.

More ingredients that help boost collagen in skin:

Sucrose is a natural sugar found in fruits, vegetables, and nuts. It is the main constituent of white sugar.

In skincare, sucrose is a humectant and can be a mild exfoliant.

Sucrose is hydrophilic, meaning it attracts water. This makes it an effective humectant and helps hydrate the skin.

Studies show sugars may worsen acne-prone skin due to it disrupting the skin's natural biome. We recommend speaking with a professional if you have any concerns.

In some products such as body scrubs, sucrose is used as an gentle exfoliant.

The term 'sucrose' comes from the french word for sugar, 'sucre'.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →