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Estée Lauder Advanced Night Repair Intense Reset Concentrate Versus Clarins Double Serum Complete Age Control Concentrate

Estée Lauder Advanced Night Repair Intense Reset Concentrate Versus Clarins Double Serum Complete Age Control Concentrate This calming serum is formulated around Lactobacillus Ferment and Resveratrol to calm redness and strengthen the skin barrier. This anti-a

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Estée Lauder Advanced Night Repair Intense Reset Concentrate Versus Clarins Double Serum Complete Age Control Concentrate

This calming serum is formulated around Lactobacillus Ferment and Resveratrol to calm redness and strengthen the skin barrier.

This anti-aging serum is formulated around Squalane to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Glycerin

Methyl Trimethicone

Bis-PEG-18 Methyl Ether Dimethyl Silane

Butylene Glycol

Isopropyl Isostearate

PPG-15 Stearyl Ether

PEG-10 Dimethicone

Faex Extract

Tripeptide-32

Sodium Hyaluronate Crosspolymer

Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Hydrolyzed Algin

Lactobacillus Ferment

Adansonia Digitata Seed Extract

Soy Amino Acids

Aminopropyl Ascorbyl Phosphate

Resveratrol

Algae Extract

Salicylic Acid

Ergothioneine

Tocopheryl Acetate

Whey Protein

Avena Sativa Kernel Extract

Citrullus Lanatus Fruit Extract

Laminaria Digitata Extract

Lens Esculenta Fruit Extract

Pyrus Malus Fruit Extract

Caffeine

Sodium PCA

Propylene Glycol Caprylate

Triticum Vulgare Germ Extract

Lavandula Angustifolia Oil

Hordeum Vulgare Extract

Anthemis Nobilis Flower Extract

Isohexadecane

Polysilicone-11

Methyldihydrojasmonate

Sodium Lactate

Disteardimonium Hectorite

Isododecane

Polyacrylate Crosspolymer-6

Squalane

Polyethylene

Propylene Carbonate

Pentylene Glycol

Disodium EDTA

BHT

Potassium Sorbate

Sodium Benzoate

Phenoxyethanol

Linalool

CI 14700

CI 19140

Water, Dimethicone, Glycerin, Methyl Trimethicone, Bis-PEG-18 Methyl Ether Dimethyl Silane, Butylene Glycol, Isopropyl Isostearate, PPG-15 Stearyl Ether, PEG-10 Dimethicone, Faex Extract, Tripeptide-32, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Algin, Lactobacillus Ferment, Adansonia Digitata Seed Extract, Soy Amino Acids, Aminopropyl Ascorbyl Phosphate, Resveratrol, Algae Extract, Salicylic Acid, Ergothioneine, Tocopheryl Acetate, Whey Protein, Avena Sativa Kernel Extract, Citrullus Lanatus Fruit Extract, Laminaria Digitata Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Caffeine, Sodium PCA, Propylene Glycol Caprylate, Triticum Vulgare Germ Extract, Lavandula Angustifolia Oil, Hordeum Vulgare Extract, Anthemis Nobilis Flower Extract, Isohexadecane, Polysilicone-11, Methyldihydrojasmonate, Sodium Lactate, Disteardimonium Hectorite, Isododecane, Polyacrylate Crosspolymer-6, Squalane, Polyethylene, Propylene Carbonate, Pentylene Glycol, Disodium EDTA, BHT, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol, Linalool, CI 14700, CI 19140

Cetearyl Isononanoate

Isononyl Isononanoate

Caprylic/Capric Triglyceride

PPG-3 Myristyl Ether

Ethylene/Propylene/Styrene Copolymer

Dipsacus Sylvestris Extract

Parfum

Propanediol

Tromethamine

Silybum Marianum Seed Oil

Carbomer

Escin

Chenopodium Quinoa Seed Extract

Ethylhexylglycerin

Theobroma Cacao Extract

Butylene/Ethylene/Styrene Copolymer

Leontopodium Alpinum Extract

Xanthan Gum

Persea Gratissima Oil Unsaponifiables

Caramel

Curcuma Longa Root Extract

Salicyloyl Phytosphingosine

Musa Sapientum Fruit Extract

Salicornia Herbacea Extract

Actinidia Chinensis Fruit Extract

Kalanchoe Pinnata Leaf Extract

Citric Acid

Myrothamnus Flabellifolia Leaf/Stem Extract

Tocopherol

Lycium Barbarum Fruit Extract

Maltodextrin

Orthosiphon Stamineus Extract

Hedychium Coronarium Root Extract

Mangifera Indica Leaf Extract

Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate

Jania Rubens Extract

Ascorbic Acid

Sodium Citrate

Engelhardtia Chrysolepis Leaf Extract

Callicarpa Japonica Fruit Extract

Water, Cetearyl Isononanoate, Glycerin, Isononyl Isononanoate, Caprylic/Capric Triglyceride, Pentylene Glycol, PPG-3 Myristyl Ether, Ethylene/Propylene/Styrene Copolymer, Dipsacus Sylvestris Extract, Butylene Glycol, Parfum, Phenoxyethanol, Propanediol, Tromethamine, Silybum Marianum Seed Oil, Carbomer, Tocopheryl Acetate, Escin, Chenopodium Quinoa Seed Extract, Ethylhexylglycerin, Squalane, Avena Sativa Kernel Extract, Theobroma Cacao Extract, Butylene/Ethylene/Styrene Copolymer, Leontopodium Alpinum Extract, Xanthan Gum, Persea Gratissima Oil Unsaponifiables, Caramel, Curcuma Longa Root Extract, Salicyloyl Phytosphingosine, Musa Sapientum Fruit Extract, Salicornia Herbacea Extract, Actinidia Chinensis Fruit Extract, Kalanchoe Pinnata Leaf Extract, Sodium Benzoate, Citric Acid, Myrothamnus Flabellifolia Leaf/Stem Extract, Disodium EDTA, Tocopherol, Lycium Barbarum Fruit Extract, Maltodextrin, Orthosiphon Stamineus Extract, Hedychium Coronarium Root Extract, Mangifera Indica Leaf Extract, Potassium Sorbate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Jania Rubens Extract, Ascorbic Acid, Sodium Citrate, Engelhardtia Chrysolepis Leaf Extract, CI 14700, Callicarpa Japonica Fruit Extract

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Avena Sativa Kernel Extract is is derived from colloidal oatmeal. Besides being a healthy breakfast, oats have many benefits in skincare too.

This ingredient helps sooth, hydrate, and protect the skin. The starches in colloidal oatmeal are able to bind water, keeping the skin hydrated.

The cellulose and fiber in colloidal oatmeal help reduce inflammation. This can also help the skin feel softer.

Colloidal Oatmeal is also an antioxidant. Antioxidants protect our skin from free-radical damage.

Oatmeal also contains beneficial compounds:

This ingredient is created by mixing grounded oatmeal and a liquid base.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ci 14700, also known as Red No. 4, is a synthetic red dye derived from petroleum. It is water soluble.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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