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Drunk Elephant A-Passioni Retinol Cream Versus Biossance Squalane + Phyto-Retinol Serum

Drunk Elephant A-Passioni Retinol Cream Versus Biossance Squalane + Phyto-Retinol Serum This anti-aging treatment is formulated around Retinol and Niacinamide to soften the look of wrinkles and refine skin texture. This anti-aging serum is formulated around Sq

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Drunk Elephant A-Passioni Retinol Cream Versus Biossance Squalane + Phyto-Retinol Serum

This anti-aging treatment is formulated around Retinol and Niacinamide to soften the look of wrinkles and refine skin texture.

This anti-aging serum is formulated around Squalane and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Coco-Caprylate

Stearic Acid

Coconut Alkanes

Glyceryl Stearate

Niacinamide

Caprylic/Capric Triglyceride

Cetearyl Alcohol

Pentylene Glycol

Passiflora Edulis Seed Oil

Retinol

Simmondsia Chinensis Seed Oil

Sclerocarya Birrea Seed Oil

Prunus Armeniaca Kernel Oil

Cetyl Ethylhexanoate

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Brassica Oleracea Acephala Leaf Extract

Brassica Oleracea Italica Extract

Tetrahexyldecyl Ascorbate

Chrysin

Persea Gratissima Oil

Linoleic Acid

Linolenic Acid

Ceramide NP

Xanthophylls

Phytosphingosine

Phytosterols

Jojoba Esters

Physalis Pubescens Fruit Juice

Stearyl Glycyrrhetinate

Oryza Sativa Extract

Glycine Soja Oil

Carthamus Tinctorius Seed Oil

Palmitoyl Hexapeptide-12

Cetyl Palmitate

Trehalose

Lauric Acid

Sodium Hyaluronate Crosspolymer

Olea Europaea Fruit Oil

Glucosamine Hcl

Tocopheryl Acetate

Coco-Caprylate/Caprate

Pisum Sativum Extract

Tocopherol

Bambusa Vulgaris Leaf/Stem Extract

Phenoxyethanol

Caprylyl Glycol

Carbomer

Trideceth-6 Phosphate

N-Hydroxysuccinimide

Ceteareth-20

Sodium Hydroxide

Laureth-23

Steareth-20

Propanediol

Chlorhexidine Digluconate

Polysorbate 20

Trisodium Ethylenediamine Disuccinate

Chlorphenesin

Potassium Sorbate

Ethylhexylglycerin

Water, Glycerin, Coco-Caprylate, Stearic Acid, Coconut Alkanes, Glyceryl Stearate, Niacinamide, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Pentylene Glycol, Passiflora Edulis Seed Oil, Retinol, Simmondsia Chinensis Seed Oil, Sclerocarya Birrea Seed Oil, Prunus Armeniaca Kernel Oil, Cetyl Ethylhexanoate, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Brassica Oleracea Acephala Leaf Extract, Brassica Oleracea Italica Extract, Tetrahexyldecyl Ascorbate, Chrysin, Persea Gratissima Oil, Linoleic Acid, Linolenic Acid, Ceramide NP, Xanthophylls, Phytosphingosine, Phytosterols, Jojoba Esters, Physalis Pubescens Fruit Juice, Stearyl Glycyrrhetinate, Oryza Sativa Extract, Glycine Soja Oil, Carthamus Tinctorius Seed Oil, Palmitoyl Hexapeptide-12, Cetyl Palmitate, Trehalose, Lauric Acid, Sodium Hyaluronate Crosspolymer, Olea Europaea Fruit Oil, Glucosamine Hcl, Tocopheryl Acetate, Coco-Caprylate/Caprate, Pisum Sativum Extract, Tocopherol, Bambusa Vulgaris Leaf/Stem Extract, Phenoxyethanol, Caprylyl Glycol, Carbomer, Trideceth-6 Phosphate, N-Hydroxysuccinimide, Ceteareth-20, Sodium Hydroxide, Laureth-23, Steareth-20, Propanediol, Chlorhexidine Digluconate, Polysorbate 20, Trisodium Ethylenediamine Disuccinate, Chlorphenesin, Potassium Sorbate, Ethylhexylglycerin

Squalane

Sodium Acrylates Copolymer

Bakuchiol

Sodium Hyaluronate

Rosa Canina Fruit Oil

Citrus Aurantium Amara Peel Oil

Biosaccharide Gum-1

Yeast Extract

Soy Amino Acids

Lecithin

Hexylene Glycol

Tetrasodium Glutamate Diacetate

Citric Acid

Linalool

Geraniol

Limonene

Water, Squalane, Niacinamide, Sodium Acrylates Copolymer, Bakuchiol, Sodium Hyaluronate, Rosa Canina Fruit Oil, Citrus Aurantium Amara Peel Oil, Biosaccharide Gum-1, Yeast Extract, Soy Amino Acids, Lecithin, Hexylene Glycol, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Tetrasodium Glutamate Diacetate, Citric Acid, Linalool, Geraniol, Limonene

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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