Drug Target Review

An enzyme in your body called cyclooxygenase (COX-2) creates chemicals that cause inflammation, fever, and pain. NSAIDs block you from producing this enzyme, which stops these conditions from happening.

NAD stands for nicotinamide adenine dinucleotide. It’s sometimes called NAD+. It’s an active form of vitamin B3. You can find NAD in every one of your cells. NAD has lots of important and complex roles throughout your body. It’s involved in many of the chemical reactions that happen inside your cells. It’s important for the way your cells make energy from nutrients. This is sometimes called energy metabolism. It also affects how your cells respond to stress. There’s evidence showing that NAD levels drop as you get older. This happens also in people with health conditions that happen more often as you age. Low NAD may have some role in diseases of your heart, brain, liver, kidneys, and skin. Given all of this, there’s an idea that NAD is generally good for you and that less of it is not. Healthy younger people have more of it. Lots of things can make NAD levels get lower. These include problems in the way your body makes NAD, damage to your body from the sun, an overactive immune system, and other assaults on your body.

In atopic dermatitis, your immune system reacts too strongly to normally harmless substances such as dust or pet fur. That overactive immune response is what causes symptoms like dryness and itching. Immunomodulators, also called immunosuppressants, reduce the activity of your immune system. You can take these medicines as a pill, by injection, or as a topical that you rub onto your skin. Immunomodulators come in a few different types. Injected and oral immunomodulators reduce the immune response throughout your body. Topical ones control the immune response in your skin.