Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

Dr. Dennis Gross Skincare DermInfusions™ Fill + Repair Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

This barrier-repair serum is formulated around Niacinamide and Ectoin to strengthen the skin barrier and soften the look of wrinkles.

This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Niacinamide

Butylene Glycol

Ectoin

Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Sodium Acetylated Hyaluronate

Sodium Hyaluronate Crosspolymer

Acetyl Hexapeptide-8

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Oligopeptide-2

Saccharide Isomerate

Camellia Sinensis Leaf Extract

Centella Asiatica Extract

Vitis Vinifera Seed Extract

Sodium Carboxymethyl Beta-Glucan

Bakuchiol

Inonotus Obliquus Extract

Tetrahydrocurcumin

Ceramide NP

Ceramide AP

Ceramide EOP

Phospholipids

Sphingolipids

Phytosphingosine

Colloidal Oatmeal

Bisabolol

Superoxide Dismutase

Terminalia Ferdinandiana Fruit Extract

Sodium PCA

Glutathione

Squalane

Caffeine

Panthenol

Butyrospermum Parkii Butter

Aloe Barbadensis Leaf Juice

Arnica Montana Flower Extract

Acetyl Glutamine

Bifida Ferment Lysate

Chamomilla Recutita Flower Extract

Withania Somnifera Root Extract

Glycolic Acid

Mandelic Acid

Lactobionic Acid

Ethylhexylglycerin

Coco-Glucoside

Lauryl Glucoside

Decyl Glucoside

Polyglyceryl-10 Laurate

Diheptyl Succinate

Dimethicone

Pentylene Glycol

Sodium Lauroyl Lactylate

Pvm/Ma Decadiene Crosspolymer

Vp/Va Copolymer

Xanthan Gum

Potassium Hydroxide

Polysorbate 20

Dimethicone Crosspolymer

Carbomer

Cholesterol

Capryloyl Glycerin/Sebacic Acid Copolymer

Leuconostoc/Radish Root Ferment Filtrate

Sodium Citrate

Citric Acid

Sodium Metasilicate

Gluconolactone

Tetrasodium Glutamate Diacetate

Caprylic/Capric Triglyceride

Jasminum Officinale Flower/Leaf Extract

Vitis Vinifera Fruit Extract

Eugenia Caryophyllus Flower Extract

Lavandula Angustifolia Flower/Leaf/Stem Extract

Raspberry Ketone

Phenoxyethanol

Potassium Sorbate

Water, Glycerin, Niacinamide, Butylene Glycol, Ectoin, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Oligopeptide-2, Saccharide Isomerate, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Vitis Vinifera Seed Extract, Sodium Carboxymethyl Beta-Glucan, Bakuchiol, Inonotus Obliquus Extract, Tetrahydrocurcumin, Ceramide NP, Ceramide AP, Ceramide EOP, Phospholipids, Sphingolipids, Phytosphingosine, Colloidal Oatmeal, Bisabolol, Superoxide Dismutase, Terminalia Ferdinandiana Fruit Extract, Sodium PCA, Glutathione, Squalane, Caffeine, Panthenol, Butyrospermum Parkii Butter, Aloe Barbadensis Leaf Juice, Arnica Montana Flower Extract, Acetyl Glutamine, Bifida Ferment Lysate, Chamomilla Recutita Flower Extract, Withania Somnifera Root Extract, Glycolic Acid, Mandelic Acid, Lactobionic Acid, Ethylhexylglycerin, Coco-Glucoside, Lauryl Glucoside, Decyl Glucoside, Polyglyceryl-10 Laurate, Diheptyl Succinate, Dimethicone, Pentylene Glycol, Sodium Lauroyl Lactylate, Pvm/Ma Decadiene Crosspolymer, Vp/Va Copolymer, Xanthan Gum, Potassium Hydroxide, Polysorbate 20, Dimethicone Crosspolymer, Carbomer, Cholesterol, Capryloyl Glycerin/Sebacic Acid Copolymer, Leuconostoc/Radish Root Ferment Filtrate, Sodium Citrate, Citric Acid, Sodium Metasilicate, Gluconolactone, Tetrasodium Glutamate Diacetate, Caprylic/Capric Triglyceride, Jasminum Officinale Flower/Leaf Extract, Vitis Vinifera Fruit Extract, Eugenia Caryophyllus Flower Extract, Lavandula Angustifolia Flower/Leaf/Stem Extract, Raspberry Ketone, Phenoxyethanol, Potassium Sorbate

PEG-8

Propanediol

Bis-PEG-18 Methyl Ether Dimethyl Silane

Methyl Gluceth-20

Glycereth-26

PEG-75

Adansonia Digitata Seed Extract

Tripeptide-32

Faex Extract

Lactobacillus Ferment

Cola Acuminata Seed Extract

Anthemis Nobilis Flower Extract

Hydrolyzed Algin

Pantethine

Lecithin

Sodium Rna

Oleth-3 Phosphate

Caprylyl Glycol

Oleth-3

Oleth-5

Choleth-24

Hydrogenated Lecithin

Jojoba Wax PEG-120 Esters

Ceteth-24

Tocopheryl Acetate

Triethanolamine

Tetrasodium EDTA

BHT

Disodium EDTA

CI 14700

CI 19140

Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Bifida Ferment Lysate is a postbiotic ingredient made by fermenting Bifidobacterium to extract a nutrient-rich mix of peptides, amino acids, vitamins, organic acids, and polysaccharides.

These components are basically the building blocks that your skin already uses to stay hydrated, repair itself, and maintain its barrier. That's why this ingredient helps your skin hold onto moisture and stay resilient against irritation.

One in-vitro study found that this ingredient tells your skin cells to produce more of the proteins (filaggrin, loricrin, and involucrin) for building a strong and healthy barrier. This study also found this ingredient to be a solid antioxidant that helped neutralize damage against UV and pollution.

A study with people from 2010 found that sensitive, reactive skin using a cream with 10% of this ingredient for a month became noticeably less dry, less reactive, and harder to irritate compared to the group using a plain cream.

In short, this ingredient is a well-tolerated ingredient that can help with barrier repair, antioxidant protection, and calming reactive skin.

This ingredient is generally considered fungal acne (Malassezia) safe; Bifidobacterium is a bacterium, not a yeast or fungus.

The fungal acne concern with fermented ingredients mainly applies to yeast-derived ferments like Saccharomyces and Galactomyces, because those are in the same kingdom as Malassezia and could theoretically contain residual compounds that feed it.

Bifida is a completely different organism, so on its own it doesn't provide a food source for the Malassezia yeast that causes fungal acne.

Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.

It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.

A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.

In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.

You'll likely see use concentrations quite low, usually 0.1-0.2%.

Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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