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Dermalogica Skin Smoothing Cream Versus Biossance Squalane + Probiotic Gel Moisturizer

Dermalogica Skin Smoothing Cream Versus Biossance Squalane + Probiotic Gel Moisturizer This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Aloe Barbadensis Extract to strengthen the skin barrier and hydrate skin. This barrier-repair moi

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Dermalogica Skin Smoothing Cream Versus Biossance Squalane + Probiotic Gel Moisturizer

This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Aloe Barbadensis Extract to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Squalane to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Caprylic/Capric Triglyceride

Ethylhexyl Hydroxystearate

Butylene Glycol

Glycerin

Palmitic Acid

Dimethicone

PEG-8

Stearic Acid

Cetearyl Alcohol

Sodium Hyaluronate

Aloe Barbadensis Extract

Vitis Vinifera Seed Extract

Saccharide Isomerate

Cucumis Sativus Fruit Extract

Arnica Montana Flower Extract

Hedera Helix Extract

Malva Sylvestris Flower Extract

Parietaria Officinalis Extract

Sambucus Nigra Flower Extract

Ascorbyl Palmitate

Trehalose

Algin

Hydrolyzed Sodium Hyaluronate

Serine

Linoleic Acid

Phospholipids

Phytosterols

Cananga Odorata Flower Oil

Urea

Hydrogenated Lecithin

Pullulan

Caprylhydroxamic Acid

Citrus Aurantium Amara Flower Extract

Tocopheryl Acetate

Tetrasodium Glutamate Diacetate

Hexanediol

Pentylene Glycol

Glyceryl Polyacrylate

Sodium Citrate

Disodium Phosphate

Palmitoyl Hydroxypropyltrimonium Amylopectin/Glycerin Crosspolymer

Caprylyl Glycol

Potassium Phosphate

Citric Acid

Tocopherol

Methylpropanediol

Polysorbate 60

Panthenol

Polyquaternium-10

Cetyl Alcohol

PEG-100 Stearate

Glyceryl Stearate

Aminomethyl Propanol

Carbomer

Ethylhexylglycerin

Sodium Hydroxide

Hydroxystearic Acid

Myristic Acid

BHT

Benzyl Benzoate

Benzyl Salicylate

Linalool

Sodium Benzoate

Phenoxyethanol

Water, Caprylic/Capric Triglyceride, Ethylhexyl Hydroxystearate, Butylene Glycol, Glycerin, Palmitic Acid, Dimethicone, PEG-8, Stearic Acid, Cetearyl Alcohol, Sodium Hyaluronate, Aloe Barbadensis Extract, Vitis Vinifera Seed Extract, Saccharide Isomerate, Cucumis Sativus Fruit Extract, Arnica Montana Flower Extract, Hedera Helix Extract, Malva Sylvestris Flower Extract, Parietaria Officinalis Extract, Sambucus Nigra Flower Extract, Ascorbyl Palmitate, Trehalose, Algin, Hydrolyzed Sodium Hyaluronate, Serine, Linoleic Acid, Phospholipids, Phytosterols, Cananga Odorata Flower Oil, Urea, Hydrogenated Lecithin, Pullulan, Caprylhydroxamic Acid, Citrus Aurantium Amara Flower Extract, Tocopheryl Acetate, Tetrasodium Glutamate Diacetate, Hexanediol, Pentylene Glycol, Glyceryl Polyacrylate, Sodium Citrate, Disodium Phosphate, Palmitoyl Hydroxypropyltrimonium Amylopectin/Glycerin Crosspolymer, Caprylyl Glycol, Potassium Phosphate, Citric Acid, Tocopherol, Methylpropanediol, Polysorbate 60, Panthenol, Polyquaternium-10, Cetyl Alcohol, PEG-100 Stearate, Glyceryl Stearate, Aminomethyl Propanol, Carbomer, Ethylhexylglycerin, Sodium Hydroxide, Hydroxystearic Acid, Myristic Acid, BHT, Benzyl Benzoate, Benzyl Salicylate, Linalool, Sodium Benzoate, Phenoxyethanol

Squalane

Lepidium Sativum Sprout Extract

Sodium Acrylates Copolymer

Capryloyl Glycerin/Sebacic Acid Copolymer

Lecithin

Diheptyl Succinate

Isoeicosane

Allantoin

Bisabolol

Sodium Phytate

Glycine Soja Sterols

Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment

Chondrus Crispus Extract

Sorbitan Oleate

Cellulose Gum

Chitosan

1,2-Hexanediol

Potassium Sorbate

Water, Glycerin, Squalane, Lepidium Sativum Sprout Extract, Sodium Acrylates Copolymer, Caprylic/Capric Triglyceride, Phenoxyethanol, Capryloyl Glycerin/Sebacic Acid Copolymer, Lecithin, Caprylyl Glycol, Diheptyl Succinate, Isoeicosane, Allantoin, Bisabolol, Sodium Phytate, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment, Chondrus Crispus Extract, Sorbitan Oleate, Cellulose Gum, Chitosan, 1,2-Hexanediol, Sodium Hyaluronate, Citric Acid, Potassium Sorbate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Linoleic Acid is also known as Vitamin F. It is a fatty acid with emollient and skin conditioning properties.

Our top layer of skin, or epidermis, naturally contains high amounts of linoleic acid.

Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.

Needless to say, linoleic acid is crucial for having a strong skin barrier.

One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.

This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.

Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.

Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.

Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.

Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Phospholipids are a family of skin-identical lipids that makeup the structural backbone of every cell membrane in your body.

In cosmetics, they function as skin conditioning agents with emulsifier and surfactant properties. They're typically sourced from soybean or sunflower lecithin (or sometimes egg yolk or marine sources).

Because they mirror the lipids naturally found in the deeper layers of your skin, topical phospholipids help reinforce the lipid matrix, reduce transepidermal water loss, and leave skin feeling conditioned.

They're also used to form liposomes, or tiny self-assembling vesible used to stabilize actives like vitamin c or retinol. This helps these ingredients integrate into the upper layers of skin more easily.

Phospholipids are compatible with everything and the CIR Expert Panel has concluded them to be safe at current use levels.

Some types of phospholipids include:

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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