Educational guide
Daptomycin: a lipopeptide antibiotic for the treatment of ...
Leading article Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections Judith N. Steenbergen Jeff Alder Grace M. Thorne Francis P. Tally Journal of Antimicrobial Chemotherapy 55(3):p 283-288, March 2005. Infections caused by
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Leading article
Daptomycin: a lipopeptide antibiotic for the treatment of serious Gram-positive infections
- Judith N. Steenbergen
- Jeff Alder
- Grace M. Thorne
- Francis P. Tally
Journal of Antimicrobial Chemotherapy 55(3):p 283-288, March 2005.
Infections caused by drug-resistant pathogens are on the rise. Daptomycin, a cyclic lipopeptide with activity against most Gram-positive pathogens, including vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus, is a newly US-FDA approved antimicrobial for complicated skin and skin structure infections (cSSSI). Daptomycin has a unique mechanism of action that results in destruction of the membrane potential. The rapid bactericidal activity of daptomycin makes it an attractive antibiotic for serious Gram-positive infections.
Copyright © British Society for Antimicrobial Chemotherapy 2005. Published by Oxford University Press. All rights reserved.