Cyclic Peptide - Peptide Cyclization

Multiple S-S Bonds Cycliztion

Disulfide-rich peptides (DSRs) are a diverse class of bioactive peptides. As DSRs have remarkable chemical stability than linear peptides, these pepetides attract the exponential interest in drug design, therapeutic agents, vaccine development, and cancer immune-therapy. Multiple disulfide bonds enforce the determined conformations close to native state, this is critical for the proper biological expression. Therefore, the connectivity between cysteines is vital, extremely precise chemical synthesis in required to ensure the proper S-S bond.

Oxidative folding is the common method for dealing with cysteine-rich peptides. Although this technique is assumed to synthesize the single themodynamic isomer, it is crucial to ensure the desired SS bond topology. Therefore, an orthogonal protective group strategy is necessary to ensure the formation of a single topological isomer. Qyaobio applies and optimizes different cysteine-protective groups to ensure our quick and straightforward synthesis of DSRs. Such as Mob, Mobm, Mmt, Acm, Ddm, Trt, Dpm, tBu, StBu, Phacm, Msbh, etc.

Therefore, effective peptide cyclization requires thorough expertise with the optimal cyclization reagents and conditions. Over the last decades, Qyaobio has developed deep experience in cyclic peptide synthesis, resulting in high success rates for even challenging peptides.