Capromorelin Protocol — Complete Dosing & Administration Guide

Dosing

How muchdo I take?

Oral: Taken by mouth as a capsule, tablet, or liquid.

Bioavailability Varies by compound — many peptides are largely broken down in the gut, so little reaches the blood intact; some small molecules absorb well.

Starting Dose

3 mg

Frequency

Twice daily

Duration

Initial weeks

One of the lower doses tested in the year-long study in older adults; raised growth hormone and IGF-1 [1].

Standard Dose

10 mg

Once daily at bedtime

Ongoing

A simple once-daily bedtime dose used in the human trial that improved lean body mass [1].

Advanced Dose

Up to 12 months in the trial

The highest daily amount studied in older adults, giving the largest gains in muscle mass and physical function [1].

Timing

Best time to take

Morning or evening, taken consistently at the same time each day

With food?

Can be taken with or without food; taking with a light meal may reduce nausea

If stacking

If combining with other GH-supporting supplements, space doses by at least 1-2 hours

Adjusting Your Dose

Increase if

+No noticeable appetite improvement after 1-2 weeks at starting dose

+GH/IGF-1 blood levels remain unchanged from baseline

Decrease if

-Excessive appetite interfering with weight management goals

-Persistent nausea, dizziness, or fluid retention

Signs of right dose

✓Healthy appetite improvement without excessive hunger

✓Improved energy and recovery after exercise

✓Measurable IGF-1 elevation on blood work

Dosing Calculator

Calculate Your Exact Dose

Step 1: Peptide Weight

Find the weight printed on your peptide vial label

Look here!

The peptide weight is printed on the label

The weight is on the label

Select Weight

Look for a number followed by 'mg' on the vial label (e.g., 5mg, 10mg)

Administration

How do Iuse it?

Reconstitution

What you need

•Oral capsule or solution as supplied

•Water for swallowing

•Measuring syringe (for liquid form)

Example

No reconstitution math needed — take the prescribed number of capsules or measured liquid dose as directed.

Standard dose is 10 mg once daily. For liquid form, use the provided measuring syringe to draw the exact volume.

Injection

Route

Not applicable — Capromorelin is administered orally only

Best sites

•Not applicable (oral administration)

Technique

1.Swallow capsule whole with a glass of water

2.If using liquid form, measure dose with provided syringe

3.Take at the same time each day for consistent results

Storage

Before reconstitution

Store at controlled room temperature (15-25°C / 59-77°F). Keep in original container, tightly sealed, away from moisture and direct sunlight.

After reconstitution

Not applicable — oral formulation does not require reconstitution. If liquid form, follow manufacturer storage instructions after opening.

Signs of degradation

Discoloration of capsules or solution

Unusual odor

Capsule cracking or powder leaking

Sample Daily Schedule

Morning

3-10 mg injection

Site: Oral

Take with or without food. Start at lower dose for first 1-2 weeks.

Morning (standard phase)

10 mg injection

Standard dose from human Phase 2 trials. Maintain consistent timing.

Morning (advanced)

30 mg injection

Highest dose studied in humans. Use only under medical supervision.

Safety

Is itsafe?

Safety Profile

Capromorelin was generally well-tolerated in Phase 2 human trials involving nearly 400 elderly participants. Most side effects were mild to moderate. Its FDA-approved veterinary use provides additional long-term safety data in mammalian species.

Human safety data comes primarily from a single Phase 2 trial (White et al., 2009) with 395 elderly subjects. Extensive veterinary safety data exists from FDA-approved products Entyce (dogs) and Elura (cats).

Common Side Effects

Experienced by some users

Appetite stimulation

Increased hunger and food intake. This is the intended mechanism for veterinary use but may be unwanted for some human users. Appetite increase is typically strongest in the first 2-3 weeks, then may stabilize or gradually decrease.

Management: If weight gain is undesired, monitor caloric intake closely and maintain consistent meal timing. Increase protein consumption to support lean muscle development. Consider timing dosing away from meal prep or dining triggers. Drink more water to help with satiety.

Fluid retention and weight gain

Mild to moderate water retention and lean weight gain due to GH effects. May cause temporary increase in body weight, typically 2-5 lbs over a 4-6 week cycle. Most weight gained is lean mass rather than fat, though some water retention is expected.

Management: Monitor body composition rather than just scale weight. Reduce sodium intake slightly to minimize water retention. Maintain adequate hydration. Most fluid retention resolves within 1-2 weeks post-cycle. Use compression garments if peripheral edema is bothersome.

Less Common

•Joint and muscle aches

•Fatigue or lethargy

•Peripheral edema (swelling)

These typically resolve with continued use or dose adjustment.

Stop and Seek Help If

×Severe allergic reaction (rash, swelling, difficulty breathing)

×Significant blood glucose elevation that doesn't normalize

×Persistent nausea, vomiting, or GI distress not relieved by dose adjustment

×Unwanted excessive appetite or weight gain

×Development of peripheral edema or fluid retention

Always consult a healthcare professional before starting or stopping any peptide or research compound. This information is for educational purposes only.

Interactions

With other peptides

✓Synergistic GH release — GHRH stimulates via a different receptor pathway

!Redundant mechanism — may not add benefit and could increase side effects

With medications

!Insulin / Oral hypoglycemics - Capromorelin may elevate blood glucose; monitor closely and adjust diabetes medications as needed

!Corticosteroids - Both affect glucose metabolism; increased hyperglycemia risk when combined

With supplements

✓Arginine / Ornithine - May modestly enhance GH release when combined with ghrelin agonists

✓Melatonin - Some evidence melatonin supports GH secretion during sleep; generally safe to combine

Want the Full Picture?

View the complete Capromorelin research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.