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Green Chemistry Principles, Greening the solid phase peptide synthesis and Green ethers to precipitate peptide after total cleavage. by | Oct 28, 2022 The following review of Green Chemistry principles along with its history, advantages and its relationship to
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Green Chemistry Principles, Greening the solid phase peptide synthesis and Green ethers to precipitate peptide after total cleavage.
by | Oct 28, 2022
The following review of Green Chemistry principles along with its history, advantages and its relationship to Solid Phase Peptide Synthesis comes from Fernando Albericio, [email protected], and Beatriz Garcia De La Torre, [email protected], at Peptide...
In situ Fmoc removal – a sustainable solid-phase peptide synthesis approach
by lsaneii | Sep 8, 2022
Promote green chemistry by saving up to 75% of solvent usage in solid-phase peptide synthesis (SPPS). An article in the Royal Society of Chemistry written by Ashish Kumar, ‡a,b,c Anamika Sharma, ‡a,b,d Beatriz G. de la Torre *a and Fernando Albericio *a,e,f advocates...
The Titan 357 and 40 years of Combinatorial Technology
by lsaneii | Aug 16, 2022
Combinatorial technology, such as the Titan 357 by AAPPTec, has been facilitating the synthesis and screening of large molecular libraries containing millions of organic compounds ever since its introduction 40 years ago. It has changed the paradigms of pharmaceutical...
Neuromedin B is essential for signaling sneezing
by Bill Bennett | Jun 16, 2021
In a paper published in Cell, researchers have shown that the peptide neuromedin B (NMB) is essential for signaling sneezing. Mice deficient in NMB recptors and mice with NMB-sensitive neurons ablated in the sneeze-evoking region did not show the sneeze reflex....
Carbodiimides and Additives
by Bill Bennett | May 19, 2021
Carbodiimides Carbodimides were some of the first coupling reagents used in solid phase peptide synthesis and are still used in many instances. Although carbodiimides might not couple as rapidly as newer coupling reagents, they still have advantages in certain...
SARS-CoV-2 Selected Papers November-December 2020
by Bill Bennett | Dec 31, 2020
Vaccines against the SARS-CoV-2 virus are just becoming available. While this is good news for controlling the spread of the virus, there has not been as much success in developing therapeutic agents for treating patients infected with SARS-CoV-2. A significant...
Alkyne-Containing Amino Acids
by Bill Bennett | Oct 20, 2020
Alkyne containing amino acids are useful building blocks for preparing modified peptides. Utilizing Sonogashira coupling or 1,3-cycloaddition with azides, they can form cyclized structures, conjugate with labels or biomolecules, and form structurally diverse amino...
Azide and Alkyne-Containing Amino Acids
by Bill Bennett | Sep 25, 2020
Azide and alkyne containing amino acids are useful building blocks for incorporating “click chemistry” into peptide synthesis. The copper(I) catalyzed 1,3-dipolar cycloaddition of azides with alkynes to form 1,4-substituted 1,2,3-triazoles is a convenient method for...
SARS CoV-2 Publications in September
by Bill Bennett | Sep 24, 2020
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors Longxing Cao, Inna Goreshnik, Brian Coventry, James Brett Case, Lauren Miller, Lisa Kozodoy,Rita E. Chen, Lauren Carter, Alexandra C. Walls, Young-Jun Park, Eva-Maria Strauch, Lance Stewart, Michael S....
Peptide Libraries for Epitope Detection of Pathogens and Vaccine Development
by Bill Bennett | Sep 22, 2020
Hess and Loeffler (K. Hess, et al., J. Proteome Res., 2020, Published Sept. 5, 2020) have published a review of how peptide libraries and microarrays can be utilized to rapidly detect immunogenic epitopes of pathogens. These epitopes can be used to rapidly develop...
SARS-CoV-2 Publications in July
by Bill Bennett | Aug 13, 2020
Covid-19 continues to be a major health problem. Research on the SARS-CoV-2 virus is continuing as potential vaccines are entering testing. These are some of the publications from July concerning SARS-CoV-2. Adaptive Evolution of Peptide Inhibitors for Mutating...
SARS CoV-2 Publications in June
by Bill Bennett | Jul 10, 2020
Covid-19, caused by the SARS-CoV-2 virus, as yet does not have a proven vaccine or drug treatment to prevent infection. Researchers globally are studying the virus and its method of infection to develop effective vaccines and drug treatments. Listed below are a few...
Peptides and Covid-19
by Bill Bennett | Apr 23, 2020
Save 20% on the COVID-19 Research Products Listed Below through July 19. Click on the links to go directly to the products: Fmoc-NH-PEG4-Propionic Acid [557756-85-1] Boc-NH-PEG6-COOH (30 atoms) [600141-83-1] Boc-NH-PEG3-Propionic Acid [1347750-75-7]...
Beta-Amino Acids and beta-Homo Amino Acids
by Bill Bennett | Apr 17, 2020
Beta-amino acids and beta-homo amino acids have related structures. In both, the amino group is attached to the second carbon atom from the acid group. The difference is in the carbon skeleton. Beta-amino acids have the same carbon skeleton as alpha-amino acids,...
Synthesizing Hydrophobic Peptides
by Bill Bennett | Feb 14, 2020
Synthesizing hydrophobic peptides is often difficult. Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates. Measures to disrupt this hydrogen bonding often significantly improve the purity and...
Hmb and Dmb Protected Derivatives
by Bill Bennett | Nov 25, 2019
Fmoc-(Fmoc-Hmb)amino acids were introduced in the 1990s to improve synthetic yields of difficult peptides, such as amyloid β, that form aggregates during synthesis. It had been noted that tertiary amide bonds in a peptide sequence prevent interchain hydrogen bonding....
Fmoc-PEG Linkers and PEGylation Reagents
by Bill Bennett | Nov 21, 2019
Modifying a peptide to include polyethylene glycol (PEG) groups may improve solubility and bioavailability. Protein PEGylation can protect the protein from proteolytic degradation and increase its half-life in biological applications, decrease its antigenisity or...
Pseudoproline Dipeptides
by Bill Bennett | Nov 15, 2019
Pseudoproline dipeptides contain oxazoles formed from serine or threonine. When treated with trifluoroacetic acid (TFA), the oxazoles are converted to serine or threonine. The oxazoles have structural similarities to proline, thus they are named pseudoprolines. Like...