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Biossance Squalane + Omega Repair Cream Versus Renee Rouleau Skin Care Phytolipid Comfort Creme

Biossance Squalane + Omega Repair Cream Versus Renee Rouleau Skin Care Phytolipid Comfort Creme This barrier-repair moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and hydrate skin. This barrier-repair moisturizer is fo

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Biossance Squalane + Omega Repair Cream Versus Renee Rouleau Skin Care Phytolipid Comfort Creme

This barrier-repair moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Simmondsia Chinensis Seed Oil and Butyrospermum Parkii Butter to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Squalane

Glycerin

Caprylic/Capric Triglyceride

Isoamyl Laurate

Butyrospermum Parkii Butter

Sorbitan Olivate

Cetearyl Olivate

Ceramide NP

Jojoba Esters

Sodium Hyaluronate

Euterpe Oleracea Sterols

Linoleic Acid

Oleic Acid

Linolenic Acid

Ethyl Linoleate

Tocopherol

Isoamyl Cocoate

Cetyl Palmitate

Sorbitan Palmitate

Cetearyl Alcohol

Ethylhexylglycerin

Carbomer

Sodium Hydroxide

Phenoxyethanol

Sodium Gluconate

Water, Squalane, Glycerin, Caprylic/Capric Triglyceride, Isoamyl Laurate, Butyrospermum Parkii Butter, Sorbitan Olivate, Cetearyl Olivate, Ceramide NP, Jojoba Esters, Sodium Hyaluronate, Euterpe Oleracea Sterols, Linoleic Acid, Oleic Acid, Linolenic Acid, Ethyl Linoleate, Tocopherol, Isoamyl Cocoate, Cetyl Palmitate, Sorbitan Palmitate, Cetearyl Alcohol, Ethylhexylglycerin, Carbomer, Sodium Hydroxide, Phenoxyethanol, Sodium Gluconate

Helianthus Annuus Seed Oil

Simmondsia Chinensis Seed Oil

Brassica Campestris/Aleurites Fordi Oil Copolymer

Cyclopentasiloxane

Coco-Glucoside

Phospholipids

Ascorbic Acid

Algae Extract

Sea Whip Extract

Yeast Beta-Glucan

Ascorbyl Palmitate

Artemisia Vulgaris Extract

Hydrogenated Lecithin

Olea Europaea Oil Unsaponifiables

Phytosteryl Isostearate

Camellia Oleifera Leaf Extract

Rosmarinus Officinalis Leaf Extract

Glycine Soja Sterols

Dimethicone

Lecithin

PEG-8

Butylene Glycol

Polysorbate 80

Cetearyl Methicone

Pentylene Glycol

Stearyl Glycyrrhetinate

PEG-100 Stearate

Citric Acid

Sodium Benzoate

Isohexadecane

Glyceryl Stearate

Disodium EDTA

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Water, Helianthus Annuus Seed Oil, Cetearyl Alcohol, Simmondsia Chinensis Seed Oil, Butyrospermum Parkii Butter, Brassica Campestris/Aleurites Fordi Oil Copolymer, Cyclopentasiloxane, Coco-Glucoside, Glycerin, Phospholipids, Ascorbic Acid, Algae Extract, Sea Whip Extract, Tocopherol, Yeast Beta-Glucan, Ascorbyl Palmitate, Artemisia Vulgaris Extract, Hydrogenated Lecithin, Olea Europaea Oil Unsaponifiables, Phytosteryl Isostearate, Camellia Oleifera Leaf Extract, Rosmarinus Officinalis Leaf Extract, Linoleic Acid, Glycine Soja Sterols, Dimethicone, Lecithin, PEG-8, Butylene Glycol, Polysorbate 80, Phenoxyethanol, Cetearyl Methicone, Pentylene Glycol, Ethylhexylglycerin, Stearyl Glycyrrhetinate, PEG-100 Stearate, Citric Acid, Sodium Benzoate, Isohexadecane, Glyceryl Stearate, Disodium EDTA, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Linoleic Acid is also known as Vitamin F. It is a fatty acid with emollient and skin conditioning properties.

Our top layer of skin, or epidermis, naturally contains high amounts of linoleic acid.

Your body uses linoleic acid to build ceramides and prostaglandins. Ceramides keep your skin's barrier hydrated and strong while prosaglandins help control inflammation and healing.

Needless to say, linoleic acid is crucial for having a strong skin barrier.

One study found applying linoleic acid rich sunflower oil to be more effective at repairing the skin barrier than olive oil.

This ingredient can also help treat acne by softening sebum to prevent clogged pores. Another study found using 2.5% linoleic acid gel for 4 weeks showed a 25% reduction in small comedones.

Studies show it can also help lighten hyperpigmentation or sun spots by disrupting the melanin production process. It also helps your skin shed melanin pigment from your skin caused by UV exposure.

Due to its role in the production of the fatty acid prostaglandin, linoleic acid can also help reduce inflammation and support wound healing.

Fun fact: Linoleic acid is an essential fatty acid. This means our bodies cannot create it on its own and we need to get it through foods such as nuts and vegetable oils.

Just know this ingredient is not always fungal-acne safe because it is a long-chain fatty acid (with 18 carbon atoms) that directly feeds the Malassezia yeast responsible for fungal acne.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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