Biossance Squalane + 10% Vitamin C Dark Spot Serum Versus Clinique Even Better Clinical™ Radical Dark Spot Corrector + Interrupter

Biossance Squalane + 10% Vitamin C Dark Spot Serum Versus Clinique Even Better Clinical™ Radical Dark Spot Corrector + Interrupter

This brightening serum is formulated around 3-O-Ethyl Ascorbic Acid and Squalane to fade the look of dark spots and brighten dull-looking skin.

This brightening serum is formulated around Ascorbyl Glucoside and Salicylic Acid to fade the look of dark spots and brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Glycerin

3-O-Ethyl Ascorbic Acid

Squalane

Lentinus Edodes Mycelium Extract

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Glycyrrhiza Glabra Root Extract

Sodium Hyaluronate

Citric Acid

Polyacrylate Crosspolymer-6

Acacia Senegal Gum

Xanthan Gum

Sodium Gluconate

Sodium Citrate

Phenoxyethanol

Ethylhexylglycerin

Water, Glycerin, 3-O-Ethyl Ascorbic Acid, Squalane, Lentinus Edodes Mycelium Extract, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Glycyrrhiza Glabra Root Extract, Sodium Hyaluronate, Citric Acid, Polyacrylate Crosspolymer-6, Acacia Senegal Gum, Xanthan Gum, Sodium Gluconate, Sodium Citrate, Phenoxyethanol, Ethylhexylglycerin

Cyclopentasiloxane

Dimethicone

Polysilicone-11

Isododecane

Butylene Glycol

Ascorbyl Glucoside

PEG-10 Dimethicone

PEG-6

Morus Bombycis Root Extract

Scutellaria Baicalensis Root Extract

Camellia Sinensis Leaf Extract

Cucumis Sativus Fruit Extract

Saccharomyces Lysate Extract

Hordeum Vulgare Extract

Salicylic Acid

Triticum Vulgare Germ Extract

Cholesterol

Oryza Sativa Bran Extract

Acetyl Glucosamine

Caffeine

Isohexadecane

Betula Alba Bark Extract

Trametes Versicolor Extract

Sodium Rna

Glycyrrhetinic Acid

Dimethoxytolyl Propylresorcinol

Di-C12-18 Alkyl Dimonium Chloride

Helianthus Annuus Seedcake

Faex Extract

Caprylyl Glycol

Propylene Glycol Dicaprate

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Polysorbate 20

Tocopheryl Acetate

Polysorbate 80

Tromethamine

Sodium Hydroxide

Hexylene Glycol

Disodium EDTA

Sodium Benzoate

Sodium Metabisulfite

Sodium Sulfite

CI 15985

CI 19140

Water, Cyclopentasiloxane, Dimethicone, Polysilicone-11, Isododecane, Butylene Glycol, Ascorbyl Glucoside, PEG-10 Dimethicone, PEG-6, Morus Bombycis Root Extract, Scutellaria Baicalensis Root Extract, Camellia Sinensis Leaf Extract, Cucumis Sativus Fruit Extract, Saccharomyces Lysate Extract, Hordeum Vulgare Extract, Salicylic Acid, Triticum Vulgare Germ Extract, Cholesterol, Oryza Sativa Bran Extract, Squalane, Acetyl Glucosamine, Sodium Hyaluronate, Caffeine, Isohexadecane, Betula Alba Bark Extract, Trametes Versicolor Extract, Sodium Rna, Glycyrrhetinic Acid, Dimethoxytolyl Propylresorcinol, Di-C12-18 Alkyl Dimonium Chloride, Helianthus Annuus Seedcake, Faex Extract, Caprylyl Glycol, Propylene Glycol Dicaprate, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Polysorbate 20, Tocopheryl Acetate, Polysorbate 80, Tromethamine, Sodium Hydroxide, Hexylene Glycol, Disodium EDTA, Sodium Benzoate, Sodium Metabisulfite, Sodium Sulfite, Phenoxyethanol, CI 15985, CI 19140

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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