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Biologique Recherche Lotion P50W Versus SkinBetter Science AlphaRet Clearing Serum

Biologique Recherche Lotion P50W Versus SkinBetter Science AlphaRet Clearing Serum This smoothing toner is formulated around Gluconolactone and Niacinamide to refine skin texture and refine the look of pores. This acne serum is formulated around Lactic Acid an

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Biologique Recherche Lotion P50W Versus SkinBetter Science AlphaRet Clearing Serum

This smoothing toner is formulated around Gluconolactone and Niacinamide to refine skin texture and refine the look of pores.

This acne serum is formulated around Lactic Acid and Ethyl Lactyl Retinoate to clear breakouts and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Gluconolactone

Niacinamide

Glycerin

Propylene Glycol

Lactic Acid

Ethoxydiglycol

Magnesium Chloride

Malic Acid

Arctium Lappa Root Extract

Cochlearia Armoracia Root Extract

Quillaja Saponaria Bark Extract

Arnica Montana Flower Extract

Capsicum Frutescens Fruit Extract

Phytic Acid

Citric Acid

Sodium Lactate

Allantoin

Serine

Sulfur

Vinegar

Sodium Salicylate

Sorbitol

Tea-Lactate

Urea

Sodium Benzoate

Sodium Bisulfite

Water, Gluconolactone, Niacinamide, Glycerin, Propylene Glycol, Lactic Acid, Ethoxydiglycol, Magnesium Chloride, Malic Acid, Arctium Lappa Root Extract, Cochlearia Armoracia Root Extract, Quillaja Saponaria Bark Extract, Arnica Montana Flower Extract, Capsicum Frutescens Fruit Extract, Phytic Acid, Citric Acid, Sodium Lactate, Allantoin, Serine, Sulfur, Vinegar, Sodium Salicylate, Sorbitol, Tea-Lactate, Urea, Sodium Benzoate, Sodium Bisulfite

Pentylene Glycol

Ethylhexyl Olivate

Sorbitan Stearate

Neopentyl Glycol Diethylhexanoate

PPG-3 Isostearyl Methyl Ether

Dimethyl Isosorbide

Glyceryl Stearate

PEG-100 Stearate

Magnesium Aluminum Silicate

Zinc PCA

Steareth-2

Ethyl Lactyl Retinoate

Salicylic Acid

Oligopeptide-10

Sodium Hyaluronate

Decylene Glycol

Artemisia Vulgaris Extract

Bisabolol

Tocopheryl Acetate

Camellia Sinensis Leaf Extract

Laminaria Digitata Extract

Tasmannia Lanceolata Fruit/Leaf Extract

Boswellia Serrata Extract

Zingiber Officinale Root Extract

Honey Extract

Oryza Sativa Bran Extract

Cetearyl Alcohol

Butylene Glycol

Xanthan Gum

Lecithin

Sclerotium Gum

Disodium EDTA

Pullulan

Ethylhexylglycerin

Silica

Phenoxyethanol

Water, Lactic Acid, Sodium Lactate, Pentylene Glycol, Ethylhexyl Olivate, Sorbitan Stearate, Neopentyl Glycol Diethylhexanoate, PPG-3 Isostearyl Methyl Ether, Glycerin, Dimethyl Isosorbide, Glyceryl Stearate, PEG-100 Stearate, Magnesium Aluminum Silicate, Niacinamide, Zinc PCA, Steareth-2, Ethyl Lactyl Retinoate, Salicylic Acid, Oligopeptide-10, Sodium Hyaluronate, Decylene Glycol, Artemisia Vulgaris Extract, Bisabolol, Tocopheryl Acetate, Camellia Sinensis Leaf Extract, Laminaria Digitata Extract, Tasmannia Lanceolata Fruit/Leaf Extract, Boswellia Serrata Extract, Zingiber Officinale Root Extract, Honey Extract, Oryza Sativa Bran Extract, Cetearyl Alcohol, Butylene Glycol, Xanthan Gum, Lecithin, Sclerotium Gum, Disodium EDTA, Pullulan, Ethylhexylglycerin, Silica, Phenoxyethanol, Sodium Benzoate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Lactic Acid is another well-loved alpha hydroxy acid (AHA). It is gentler than glycolic acid but still highly effective.

Its main role is to exfoliate the surface of the skin by loosening the “glue” that holds dead skin cells together. Shedding those old cells leads to smoother, softer, and more even-toned skin.

Because lactic acid molecules are larger than glycolic acid, they don’t penetrate as deeply. This means they’re less likely to sting or irritate, making it a great choice for beginners or those with sensitive skin.

Like glycolic acid, it can:

Lactic acid also acts as a humectant (like hyaluronic acid). It can draw water into the skin to improve hydration and also plays a role in the skin's natural moisturizing factor (NMF) in the form of sodium lactate.

Studies show it can boost ceramide production to strengthen the skin barrier and even help balance the skin’s microbiome.

To get results, choose products with a pH between 3-4.

Lower strengths (5-12%) focus on surface exfoliation; higher strengths (12% and up) can reach deeper in the dermis (deeper, supportive layer) to improve skin texture and firmness over time.

Though it was originally derived from milk, most modern lactic acid used in skincare is vegan. It is made through non-dairy fermentation to create a bio-identical and stable form suitable for all formulations.

When lactic acid shows up near the end of an ingredient list, it usually means the brand added just a tiny amount to adjust the product’s pH.

Legend has it that Cleopatra used to bathe in sour milk to help reduce wrinkles.

Lactic acid is truly a gentle multitasker: it exfoliates, hydrates, strengthens, and brightens. It's a great ingredient for giving your skin a smooth, glowing, and healthy look without the harshness of stronger acids.

Read more about some other popular AHA's here:

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.

This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.

High percentages of Sodium Lactate can have an exfoliating effect.

Fun fact: Sodium Lactate is produced from fermented sugar.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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