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Artistry Beauty Renewing Reactivation Eye Cream Versus Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream

Artistry Beauty Renewing Reactivation Eye Cream Versus Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream This anti-aging eye moisturizer is formulated around Butyrospermum Parkii Butter and Squalane to soften the look of wrinkles and hydrate skin.

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Artistry Beauty Renewing Reactivation Eye Cream Versus Estée Lauder Advanced Night Repair Supercharged Eye Gel-Cream

This anti-aging eye moisturizer is formulated around Butyrospermum Parkii Butter and Squalane to soften the look of wrinkles and hydrate skin.

This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Butyrospermum Parkii Butter

Butylene Glycol

Propanediol

Dimethicone

Caprylic/Capric Triglyceride

Isostearyl Palmitate

Triethylhexanoin

Glycerin

Glyceryl Stearate

PEG-100 Stearate

Limnanthes Alba Seed Oil

Cetyl Alcohol

Salvia Hispanica Seed Oil

Behenyl Alcohol

Polymethyl Methacrylate

Sorbitan Stearate

Pentylene Glycol

Hdi/Trimethylol Hexyllactone Crosspolymer

Arginine

Spinacia Oleracea Leaf Extract

Squalane

Petrolatum

Carbomer

Polysilicone-11

Chlorphenesin

Propylene Glycol Dicaprate

Phenoxyethanol

4-T-Butylcyclohexanol

Allantoin

Caffeine

Disodium EDTA

Helianthus Annuus Seed Extract

Pullulan

Isononyl Isononanoate

Osmanthus Fragrans Flower Extract

Ophiopogon Japonicus Root Extract

Panthenol

Euglena Gracilis Extract

Isohexadecane

Citrullus Lanatus Fruit Extract

Lecithin

Avena Sativa Kernel Extract

Dipotassium Glycyrrhizate

Stearyl Glycyrrhetinate

Chenopodium Quinoa Seed Extract

Lens Esculenta Fruit Extract

Pyrus Malus Fruit Extract

Nannochloropsis Oculata Extract

Ammonium Polyacryloyldimethyl Taurate

Hesperidin Methyl Chalcone

Chlorella Vulgaris Extract

Beta-Glucan

Salvia Hispanica Seed Extract

Silica

Hydrolyzed Candida Saitoana Extract

Sodium Benzoate

Yeast Extract

Hordeum Vulgare Extract

Punica Granatum Fruit Extract

Sodium Hyaluronate

Steareth-20

Tocopheryl Acetate

Potassium Sorbate

Tocopherol

Glycine Soja Oil

1,2-Hexanediol

Caprylyl Glycol

Polysorbate 80

Zinc PCA

Sodium Lactate

Polysorbate 20

Curcuma Longa Root Extract

Ethylhexylglycerin

Cucumis Sativus Fruit Extract

Sodium PCA

Oenothera Biennis Seed Extract

Sodium Citrate

Ceramide NP

Beta-Sitosterol

Dipeptide-2

Oenothera Biennis Oil

Perilla Ocymoides Seed Oil

Rosmarinus Officinalis Leaf Extract

Citric Acid

Palmitoyl Tetrapeptide-7

Helianthus Annuus Seed Oil

BHT

Biotin

Water, Butyrospermum Parkii Butter, Butylene Glycol, Propanediol, Dimethicone, Caprylic/Capric Triglyceride, Isostearyl Palmitate, Triethylhexanoin, Glycerin, Glyceryl Stearate, PEG-100 Stearate, Limnanthes Alba Seed Oil, Cetyl Alcohol, Salvia Hispanica Seed Oil, Behenyl Alcohol, Polymethyl Methacrylate, Sorbitan Stearate, Pentylene Glycol, Hdi/Trimethylol Hexyllactone Crosspolymer, Arginine, Spinacia Oleracea Leaf Extract, Squalane, Petrolatum, Carbomer, Polysilicone-11, Chlorphenesin, Propylene Glycol Dicaprate, Phenoxyethanol, 4-T-Butylcyclohexanol, Allantoin, Caffeine, Disodium EDTA, Helianthus Annuus Seed Extract, Pullulan, Isononyl Isononanoate, Osmanthus Fragrans Flower Extract, Ophiopogon Japonicus Root Extract, Panthenol, Euglena Gracilis Extract, Isohexadecane, Citrullus Lanatus Fruit Extract, Lecithin, Avena Sativa Kernel Extract, Dipotassium Glycyrrhizate, Stearyl Glycyrrhetinate, Chenopodium Quinoa Seed Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Nannochloropsis Oculata Extract, Ammonium Polyacryloyldimethyl Taurate, Hesperidin Methyl Chalcone, Chlorella Vulgaris Extract, Beta-Glucan, Salvia Hispanica Seed Extract, Silica, Hydrolyzed Candida Saitoana Extract, Sodium Benzoate, Yeast Extract, Hordeum Vulgare Extract, Punica Granatum Fruit Extract, Sodium Hyaluronate, Steareth-20, Tocopheryl Acetate, Potassium Sorbate, Tocopherol, Glycine Soja Oil, 1,2-Hexanediol, Caprylyl Glycol, Polysorbate 80, Zinc PCA, Sodium Lactate, Polysorbate 20, Curcuma Longa Root Extract, Ethylhexylglycerin, Cucumis Sativus Fruit Extract, Sodium PCA, Oenothera Biennis Seed Extract, Sodium Citrate, Ceramide NP, Beta-Sitosterol, Dipeptide-2, Oenothera Biennis Oil, Perilla Ocymoides Seed Oil, Rosmarinus Officinalis Leaf Extract, Citric Acid, Palmitoyl Tetrapeptide-7, Helianthus Annuus Seed Oil, BHT, Biotin

Methyl Trimethicone

Bifida Ferment Lysate

Dimethicone/Vinyl Dimethicone Crosspolymer

Sucrose

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Trehalose

Tripeptide-32

Adansonia Digitata Seed Extract

Lavandula Angustifolia Flower Extract

Lactobacillus Ferment

Faex Extract

Hypnea Musciformis Extract

Sodium Rna

Anthemis Nobilis Flower Oil

Poria Cocos Sclerotium Extract

Phytosphingosine

Hydrolyzed Algin

Hordeum Distichon Extract

Jojoba Esters

Triticum Vulgare Germ Oil

Hydrogenated Lecithin

Jojoba Alcohol

Isopropyl Jojobate

PEG/PPG-18/18 Dimethicone

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tromethamine

Sorbitan Oleate

Polysorbate 40

Potassium Gluconate

CI 77491

CI 77492

Water, Dimethicone, Methyl Trimethicone, Bifida Ferment Lysate, Dimethicone/Vinyl Dimethicone Crosspolymer, Propanediol, Petrolatum, Sucrose, Glycerin, Butylene Glycol, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Trehalose, Tripeptide-32, Adansonia Digitata Seed Extract, Lavandula Angustifolia Flower Extract, Sodium Hyaluronate, Lactobacillus Ferment, Tocopheryl Acetate, Faex Extract, Hypnea Musciformis Extract, Sodium Rna, Caffeine, Squalane, Anthemis Nobilis Flower Oil, Poria Cocos Sclerotium Extract, Citrullus Lanatus Fruit Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Ethylhexylglycerin, Sodium PCA, Phytosphingosine, Hydrolyzed Algin, Hordeum Distichon Extract, Jojoba Esters, Triticum Vulgare Germ Oil, Hydrogenated Lecithin, Lecithin, Isohexadecane, Jojoba Alcohol, Isopropyl Jojobate, PEG/PPG-18/18 Dimethicone, Polysorbate 80, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Sorbitan Oleate, Sodium Lactate, Polysorbate 40, Potassium Gluconate, Tocopherol, BHT, Phenoxyethanol, Potassium Sorbate, Sodium Benzoate, CI 77491, CI 77492

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

BHT is a synthetic antioxidant and preservative.

As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Citrullus Lanatus Fruit Extract comes from the watermelon. Watermelon has antioxidant and anti-inflammatory properties.

Watermelons are rich in antioxidants such as Vitamin A, Vitamin C and lycopene. It also contains sugars and amino acids, such as arginine and glutathione.

Lycopene is a potent antioxidant. Besides helping to protect your skin against free-radical molecules, it also helps soothe the skin. Lycopene gives watermelon the distinct red color.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Isohexadecane is added to enhance texture, emulsify, and to help cleanse. It is an isoparrafin. It is a component of petrolatum.

Due to its large size, Isohexadecane is not absorbed by the skin. Instead, it sits on top and acts as an emollient. Emollients help keep your skin soft and smooth by trapping moisture within.

Isohexadecane is often used in products designed to help oily skin. It is lightweight and non-greasy while helping to moisturize. When mixed with silicones, it gives a product a silky feel.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

We don't have a description for Lens Esculenta Fruit Extract yet.

Petrolatum is more commonly known as petroleum jelly. It is created by mixing waxes and mineral oils.

This ingredient is effective at reducing water loss by 99%. This is because it is an occlusive. Occlusives create a hydrophobic barrier on the skin to prevent evaporation. This property makes it great for hydrating dry skin.

Pro tip: Use occlusives, such as this ingredient, on damp skin for the best results.

The quality or origin of petrolatum is only known when disclosed by the brand. Most cosmetic petrolatum has gone through several purification stages.

Another benefit of occlusives is it protects your skin against infection or allergies.

Petrolatum is fungal acne safe. It is a hydrocarbon with no fatty acid structure, so Malassezia cannot metabolize it. In-vitro studies support negligible growth stimulation as well.

It's also worth noting that petrolatum has a comedogenic rating of 0. In updated rabbit ear testing (and in human testing), petrolatum was found to be not comedogenic. This means it didn’t promote comedone formation in standard models.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Polysorbate 80 is a synthetic surfactant and emulsifier derived from sorbitol and oleic acid.

It reduces the surface tension between oil and water phases to help them stay mixed and stable in a formulation. In other words, it prevents your formulas from separating into an oily mess.

The CIR Expert Panel has evaluated the scientific data and found this ingredient to be safe, non-irritating, and non-sensitizing at concentrations up to 5% (it's even approved by the FDA as an OTC eye drop ingredient).

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Pyrus Malus Fruit Extract is extract from Apples. Apples are rich in Vitamin C, sugars, and antioxidants.

The sugar in Apples are humectants and help hydrate the skin. On top of that, apples also contain some acids, such as malic acid. These acids may have a mild exfoliating effect.

Last, the phytochemicals found in apples are strong antioxidants. These antioxidants help with anti-aging as they protect your skin cells against oxidative damage.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sodium Lactate is the sodium salt of lactic acid, an AHA. It is a humectant and sometimes used to adjust the pH of a product.

This ingredient is part of our skin's NMF, or natural moisturizing factor. Our NMF is essential for the hydration of our top skin layers and plasticity of skin. NMF also influences our skin's natural acid mantle and pH, which protects our skin from harmful bacteria.

High percentages of Sodium Lactate can have an exfoliating effect.

Fun fact: Sodium Lactate is produced from fermented sugar.

Sodium PCA (the salt of PCA) is one of the most well-established humectants in skincare.

Why is it so special? Your skin already makes it naturally; it's a natural component of your skin's Natural Moisturizing Factor (NMF), or the mix of water-binding compounds inside your skin cells that keeps things soft and hydrated.

As a cosmetic ingredient, it grabs water and holds it in the upper layers of skin to smooth roughness and ease dehydration.

There's some clinical support for the NMF approach with a study showing that a cream built to mimic the skin's NMF significantly boosted hydration.

Safety-wise, this ingredient non-irritating, non-comedogenic, and non-phototoxic in testing, with minimal skin absorption.

It also works really well with other hydrators like glycerin or hyaluronic acid, and typical usage is somewhere between 0.2-4%.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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