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Antihemophilic Factor, Fc Fusion Protein, Recombinant injection

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Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

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Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services. Policy

ANTIHEMOPHILIC FACTOR, Fc FUSION PROTEIN (an tee hee moe FIL ik fak tir, Fc FYOO zhuh n PROH teen) prevents and treats bleeding episodes in people with hemophilia A, a condition caused by low levels of blood clotting factor VIII. It works by increasing factor VIII levels in your body. This helps your blood clot normally, which reduces bleeding.

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This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): ALTUVIIIO, ELOCTATE

They need to know if you have any of these conditions:

  • An unusual or allergic reaction to recombinant antihemophilic factor Fc fusion protein, other medications, foods, dyes, or preservatives
  • Pregnant or trying to get pregnant
  • Breast-feeding

This medication is injected into a vein. It is usually given by your care team in a hospital or clinic setting.

If you get this medication at home, you will be taught how to prepare and give it. Use exactly as directed. Take it as directed on the prescription label at the same time every day. Keep taking it unless your care team tells you to stop.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or care team to get one.

Talk to your care team about the use of this medication in children. While it may be prescribed for children for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

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NOTE: This medicine is only for you. Do not share this medicine with others.

If you get this medication at the hospital or clinic: It is important not to miss your dose. Call your care team if you are unable to keep an appointment.

If you give yourself this medication at home: If you miss a dose, take it as soon as you can, then continue your normal schedule. If it is almost time for your next dose, take only that dose. Do not take double or extra doses. Call your care team with questions.

Interactions are not expected.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Your condition will be monitored carefully while you are receiving this medication.

You may need blood work while taking this medication.

Wear a medical ID bracelet or chain. Carry a card that describes your condition. List the medications and doses you take on the card.

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Back pain
  • Fever
  • General discomfort and fatigue
  • Headache
  • Joint pain
  • Vomiting

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep out of the reach of children and pets.

This medication is usually given in a hospital or clinic. If you are using this medication at home, you will be instructed on how to store this medication. Get rid of any unused medication after the expiration date.

To get rid of medications that are no longer needed or have expired:

  • Take the medication to a medication take-back program. Check with your pharmacy or law enforcement to find a location.
  • If you cannot return the medication ask your pharmacist or care team how to get rid of this medication safely.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

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Note: Introduction and Additional Common Questions written and medically approved by Cleveland Clinic professionals.

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01How does interleukin-2 (IL-2)-diphtheria toxin fusion protein work?

Interleukin-2 (IL-2)-diphtheria toxin fusion protein is a biological product used for the treatment of cutaneous T-cell lymphoma (CTCL) in adults. IL-2-diphtheria toxin fusion protein is a kind of treatment that is designed to kill cancer cells in cutaneous T-cell lymphoma by carrying and releasing the diphtheria toxin inside the tumor cells. Cutaneous T-cell lymphomas are a group of rare cancers that start in the T-lymphocytes, also known as T-cells, an integral part of the immune system. CTCL affects the skin, but it is not a skin cancer. It is a type of lymphoma in which T-cells within the skin become cancerous, cause inflammations and rashes, and damage the skin. The skin contains a large number of T-cells which help fight infections. CTCL occurs when these T-cells turn abnormal and grow out of control. Initially it only affects the skin, but can spread to other organs such as lymph nodes, liver and spleen, in advanced stages. CTCL is classified as a type of non-Hodgkin lymphoma (NHL). Interleukin-2 is a protein produced by activated T-cells, and is a growth factor that promotes the growth of T-cells. The activated T-cells in the skin in cutaneous T-cell lymphomas produce this protein which aids the cancerous growth of T-cells. Interleukin-2 (IL-2)-diphtheria toxin fusion protein binds to IL-2 receptors on the tumor cells and kills them. Interleukin-2 (IL-2)-diphtheria toxin fusion protein is produced using DNA recombinant technology and contains human IL-2 and diphtheria toxin fragments. The IL-2 helps the drug bind to T-cells that express IL-2 receptors, and once the molecule enters the cell, the diphtheria toxin separates and inhibits protein synthesis, which leads to cell death. Currently, the only approved interleukin-2 (IL-2)-diphtheria toxin fusion protein therapy is denileukin diftitiox. It was originally approved by the FDA to treat CTCL, under the brand name of Ontak in 1999. Ontak was withdrawn in 2014, and the treatment has now been approved in August 2024 under the brand name of Lymphir.

Source: www.rxlist.com ↗
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