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Anastrozole and RAD-140 Interaction: Avoid | Peptide Database

Compound Profiles Anastrozole Aromatase Inhibitor | Estrogen Management Anastrozole competitively binds to the heme group of the aromatase enzyme (cytochrome P450 19A1), reversibly inhibiting its catalytic activity. Aromatase is responsible for the final step

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Compound Profiles

Anastrozole

Aromatase Inhibitor | Estrogen Management

Anastrozole competitively binds to the heme group of the aromatase enzyme (cytochrome P450 19A1), reversibly inhibiting its catalytic activity. Aromatase is responsible for the final step in estrogen biosynthesis, converting testosterone to estradiol and androstenedione to estrone in peripheral tissues including adipose, muscle, liver, and brain.

RAD-140

Selective Androgen Receptor Modulator | Investigational SARM

RAD-140 binds to the androgen receptor (AR) with high affinity and selectivity, functioning as a full agonist in muscle and bone tissue while exhibiting minimal agonist activity in the prostate and other androgen-sensitive tissues. This tissue selectivity is achieved through differential cofactor recruitment: upon binding to the AR, RAD-140 induces a conformational change that favors interaction with coactivators predominantly expressed in skeletal muscle and bone, rather than those prevalent in prostate or sebaceous glands.

Combined Organ Load

Shared Safety Flags

Frequently Asked Questions

Can I take Anastrozole with RAD-140?

Combining Anastrozole with RAD-140 is not recommended. Both Anastrozole and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently.

Is Anastrozole and RAD-140 safe together?

This combination carries significant risk. Both Anastrozole and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. Consult a healthcare professional before combining.

What are the interactions between Anastrozole and RAD-140?

Both Anastrozole and RAD-140 carry hepatotoxic risk. Combining hepatotoxic compounds significantly increases liver damage potential. If unavoidable, include liver support (TUDCA/NAC) and monitor ALT/AST frequently. This assessment has 53% confidence and is inferred from pharmacological mechanism analysis.

How should I time Anastrozole and RAD-140?

Anastrozole has a half-life of ~40-50 hours and RAD-140 has a half-life of ~60 hours. No specific timing requirements identified for this combination, but separating administration can help monitor individual effects.

This interaction analysis is compiled from research literature and pharmacological mechanism data. This assessment is inferred from known mechanisms and may not reflect all real-world outcomes. Always consult a healthcare professional before combining compounds.

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

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Why is TB-500 dosed 2.5x higher in Tri-Heal Max versus standard Wolverine Stack?

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comparison

What's the addiction risk of phenibut vs benzodiazepines?

Phenibut carries similar addiction and withdrawal risk to benzodiazepines despite not being a benzo. Physical dependence can develop in as little as 1-2 weeks of daily use, and withdrawal i…

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Research context

Read sources and limitations before applying a claim.

Can PE-22-28 work as a standalone antidepressant, or is it just for research?

PE-22-28 shows rapid antidepressant effects in animal models (within 4 days), but it's currently research-only with no human clinical trials completed. It's not approved for therapeutic use. However, the preclinical evidence is strong enough that clinical development may follow if pharmaceutical companies invest in it.

Source: peptide-db.com ↗

Research Indications

First-line pharmacotherapy for ED of various etiologies including psychogenic, vasculogenic, and mixed. Effective in a broad range of patient populations including those with diabetes and post-prostatectomy. Daily low-dose tadalafil maintains steady plasma levels, allowing for spontaneous sexual activity without the need to time dosing around intercourse. FDA-approved at 5mg daily for treatment of BPH signs and symptoms, including urinary frequency, urgency, weak stream, and nocturia. Can be used alone or with alpha-blockers. Relaxes smooth muscle in the prostate, bladder neck, and urethra via PDE5 inhibition, improving urinary flow and reducing symptom severity. FDA-approved as Adcirca (40mg daily) for PAH (WHO Group 1) to improve exercise ability. Relaxes pulmonary vasculature and reduces right ventricular afterload. Enhances NO-cGMP signaling in systemic vasculature, improving flow-mediated dilation and arterial compliance. May slow progression of endothelial dysfunction. Modest systemic vasodilation produces small but clinically meaningful reductions in systolic and diastolic blood pressure, particularly in patients with mild hypertension. Enhanced NO-mediated vasodilation may increase blood flow to working muscles during resistance training, producing a more pronounced pump effect. Evidence is largely anecdotal but mechanistically plausible. Some evidence suggests PDE5 inhibition can improve exercise performance at altitude by reducing pulmonary artery pressure and improving oxygen delivery.

Source: peptide-db.com ↗
Practical and safety references

These excerpts are educational, not personalised medical instructions.

How-to reference

How to Stack Them

A practical approach based on evidence tiers: Foundation (everyone): CoQ10 100-300mg daily (especially if on statins or over 50) Creatine 3-5g daily Second layer (longevity-focused): NMN 250-500mg or NR 300mg daily Urolithin A 500-1000mg daily Research tier (advanced, with medical oversight): NAD+ IV 250-500mg weekly or SubQ 100-500mg 2-3x weekly SS-31 5-10mg daily SubQ MOTS-c 5-10mg daily SubQ (WADA prohibited) Check interactions between any peptides in your stack: Interaction checker Use our cost calculator to work out per-dose pricing.

Source: peptide-db.com ↗
Side effects

Common Side Effects

Headache (most common side effect, typically caused by insufficient choline intake -- co-supplementation with Alpha-GPC or CDP-Choline usually resolves this) Irritability and restlessness, particularly at doses exceeding 30 mg/day Insomnia if taken too late in the day Mild gastrointestinal discomfort when taken on an empty stomach

Source: peptide-db.com ↗
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Peptide Therapy Guide Editorial Team

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