AMPLE:N Peptide Shot Ampoule Versus Mizon Peptide 500

AMPLE:N Peptide Shot Ampoule Versus Mizon Peptide 500

This anti-aging ampoule is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging serum is formulated around Sodium Hyaluronate and Copper Tripeptide-1 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Dipropylene Glycol

Alcohol

PEG-32

Biosaccharide Gum-1

Niacinamide

Trehalose

Adenosine

Acetyl Hexapeptide-8

Arginine

Panthenol

Hydrogenated Lecithin

Beta-Glucan

Dipotassium Glycyrrhizate

Helichrysum Arenarium Extract

Yeast Extract

Palmitoyl Pentapeptide-4

Pearl Extract

Dimethicone

PEG-60 Hydrogenated Castor Oil

1,2-Hexanediol

Carbomer

Xanthan Gum

Titanium Dioxide

Sodium Palmitoyl Sarcosinate

Glyceryl Acrylate/Acrylic Acid Copolymer

Mica

Caramel

Agar

Calcium Alginate

Gellan Gum

Polysorbate 20

Propylene Glycol

Caprylyl Glycol

Glyceryl Caprylate

Phenylpropanol

Palmitoyl Oligopeptide

Lactic Acid

Polyvinyl Alcohol

Glycolic Acid

Phenoxyethanol

Parfum

Ethylhexylglycerin

Tetrasodium EDTA

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, Alcohol, PEG-32, Biosaccharide Gum-1, Niacinamide, Trehalose, Adenosine, Acetyl Hexapeptide-8, Arginine, Panthenol, Hydrogenated Lecithin, Beta-Glucan, Dipotassium Glycyrrhizate, Helichrysum Arenarium Extract, Yeast Extract, Palmitoyl Pentapeptide-4, Pearl Extract, Dimethicone, PEG-60 Hydrogenated Castor Oil, 1,2-Hexanediol, Carbomer, Xanthan Gum, Titanium Dioxide, Sodium Palmitoyl Sarcosinate, Glyceryl Acrylate/Acrylic Acid Copolymer, Mica, Caramel, Agar, Calcium Alginate, Gellan Gum, Polysorbate 20, Propylene Glycol, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Palmitoyl Oligopeptide, Lactic Acid, Polyvinyl Alcohol, Glycolic Acid, Phenoxyethanol, Parfum, Ethylhexylglycerin, Tetrasodium EDTA

Methylpropanediol

Polyglyceryl-10 Oleate

Sodium Hyaluronate

Copper Tripeptide-1

Disodium EDTA

Glycine

Tocopherol

Serine

Glutamic Acid

Houttuynia Cordata Extract

Centella Asiatica Extract

Hydrolyzed Hyaluronic Acid

Hydrolyzed Sodium Hyaluronate

Hyaluronic Acid

Hydroxypropyltrimonium Hyaluronate

Potassium Hyaluronate

Aspartic Acid

Leucine

Pentylene Glycol

Alanine

Lysine

Tyrosine

Phenylalanine

Threonine

Proline

Valine

Isoleucine

Sodium

Sodium Hyaluronate Crosspolymer

Histidine

Methionine

Cysteine

Sodium Acetylated Hyaluronate

Phosphatidylcholine

Sh-Oligopeptide-1

Oligopeptide-29

Oligopeptide-32

Sh-Polypeptide-1

Sh-Oligopeptide-2

Sh-Polypeptide-22

Water, Methylpropanediol, Butylene Glycol, 1,2-Hexanediol, Polyglyceryl-10 Oleate, Ethylhexylglycerin, Sodium Hyaluronate, Copper Tripeptide-1, Adenosine, Disodium EDTA, Biosaccharide Gum-1, Beta-Glucan, Glycine, Tocopherol, Serine, Glutamic Acid, Houttuynia Cordata Extract, Centella Asiatica Extract, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Aspartic Acid, Leucine, Pentylene Glycol, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Threonine, Proline, Valine, Isoleucine, Sodium, Sodium Hyaluronate Crosspolymer, Histidine, Methionine, Cysteine, Sodium Acetylated Hyaluronate, Phosphatidylcholine, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Oligopeptide-29, Oligopeptide-32, Palmitoyl Pentapeptide-4, Sh-Polypeptide-1, Sh-Oligopeptide-2, Sh-Polypeptide-22, Phenoxyethanol

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".

It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.

The comparison to Botox does have limits because the molecule is water-loving and relatively large.

Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.

So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.

A 12 week human study of a multi-ingredient regimen containing this ingredient saw:

While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).

Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.

It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.

On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin

The more interesting story is underneath:

Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.

A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.

It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.

This ingredient gets along with pretty much everything and is typically used around 0.1-1%.

Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.

Biosaccharide Gum-1 is a sugar created by fermenting sorbitol (which usually comes from potato starch!). It is known for its soothing and moisturizing properties.

Manufacturer tests show this ingredient helped reduce irritation from lactic acid by almost half and kept skin hydrated long-term as a humectant

Beyond hydration, Biosaccharide Gum-1 gives formulas a silky, non-sticky feel.

This ingredient is gentle, versatile, and suitable for all skin types.

Fun fact: Similar sugars can be found naturally in fruits like apples and pears.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

You might know this ingredient as Matrixyl. It is a synthetic peptide made up of five amino acids attached to a palmitic acid, a fatty acid that helps it absorb into skin more easily.

As a signal peptide, Matrixyl acts like a little messenger. Once it reaches your skin cells, it tells them to ramp up production of collagen, elastin, and other proteins that keep skin looking firm and smooth.

A 12 week clinical study found that a moisturizer containing just 3 ppm of Matrixyl led to a significant improvement in fine-lines and wrinkles. Another study showed an 18% reduction in wrinkle depth, 37% reduction in wrinkle thickness, and a 21% improvement in skin firmness after just 28 days of twice-daily use.

The coolest part is that it works at incredibly low concentrations (like 0.0003%) and it plays well with other actives.

The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization.

Fun fact: Matrixyl was originally developed by French company Sederma and Procter & Gamble.

Read more about other common types of peptides here:

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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