AMPLE:N Peptide Shot Ampoule Versus innisfree Retinol Cica Repair Ampoule

AMPLE:N Peptide Shot Ampoule Versus innisfree Retinol Cica Repair Ampoule

This anti-aging ampoule is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This smoothing ampoule is formulated around Niacinamide and Asiaticoside to refine skin texture and calm redness.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Dipropylene Glycol

Alcohol

PEG-32

Biosaccharide Gum-1

Niacinamide

Trehalose

Adenosine

Acetyl Hexapeptide-8

Arginine

Panthenol

Hydrogenated Lecithin

Beta-Glucan

Dipotassium Glycyrrhizate

Helichrysum Arenarium Extract

Yeast Extract

Palmitoyl Pentapeptide-4

Pearl Extract

Dimethicone

PEG-60 Hydrogenated Castor Oil

1,2-Hexanediol

Carbomer

Xanthan Gum

Titanium Dioxide

Sodium Palmitoyl Sarcosinate

Glyceryl Acrylate/Acrylic Acid Copolymer

Mica

Caramel

Agar

Calcium Alginate

Gellan Gum

Polysorbate 20

Propylene Glycol

Caprylyl Glycol

Glyceryl Caprylate

Phenylpropanol

Palmitoyl Oligopeptide

Lactic Acid

Polyvinyl Alcohol

Glycolic Acid

Phenoxyethanol

Parfum

Ethylhexylglycerin

Tetrasodium EDTA

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, Alcohol, PEG-32, Biosaccharide Gum-1, Niacinamide, Trehalose, Adenosine, Acetyl Hexapeptide-8, Arginine, Panthenol, Hydrogenated Lecithin, Beta-Glucan, Dipotassium Glycyrrhizate, Helichrysum Arenarium Extract, Yeast Extract, Palmitoyl Pentapeptide-4, Pearl Extract, Dimethicone, PEG-60 Hydrogenated Castor Oil, 1,2-Hexanediol, Carbomer, Xanthan Gum, Titanium Dioxide, Sodium Palmitoyl Sarcosinate, Glyceryl Acrylate/Acrylic Acid Copolymer, Mica, Caramel, Agar, Calcium Alginate, Gellan Gum, Polysorbate 20, Propylene Glycol, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Palmitoyl Oligopeptide, Lactic Acid, Polyvinyl Alcohol, Glycolic Acid, Phenoxyethanol, Parfum, Ethylhexylglycerin, Tetrasodium EDTA

Dibutyl Adipate

Caprylic/Capric Triglyceride

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Helianthus Annuus Seed Oil

Cholesterol

Allantoin

Glycine Soja Oil

Tocopherol

Tocopheryl Acetate

Sodium Methyl Stearoyl Taurate

Propanediol

Daucus Carota Sativa Root Extract

Asiaticoside

Madecassic Acid

Camellia Sinensis Seed Extract

Asiatic Acid

Retinol

Stearyl Glycyrrhetinate

Hyaluronic Acid

Mannitol

Ceramide NP

Beta-Carotene

Phytosphingosine

BHT

Salicylic Acid

Acetyl Tetrapeptide-11

Water, Glycerin, Butylene Glycol, Niacinamide, Dibutyl Adipate, Caprylic/Capric Triglyceride, 1,2-Hexanediol, Hydrogenated Lecithin, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Helianthus Annuus Seed Oil, Cholesterol, Allantoin, Glycine Soja Oil, Tocopherol, Tocopheryl Acetate, Sodium Methyl Stearoyl Taurate, Propanediol, Daucus Carota Sativa Root Extract, Ethylhexylglycerin, Adenosine, Asiaticoside, Madecassic Acid, Camellia Sinensis Seed Extract, Asiatic Acid, Retinol, Stearyl Glycyrrhetinate, Hyaluronic Acid, Mannitol, Ceramide NP, Beta-Glucan, Beta-Carotene, Phytosphingosine, BHT, Salicylic Acid, Acetyl Tetrapeptide-11

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.

It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.

On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin

The more interesting story is underneath:

Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.

A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.

It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.

This ingredient gets along with pretty much everything and is typically used around 0.1-1%.

Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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