Alexamorelin Protocol — Complete Dosing & Administration Guide

Dosing

How muchdo I take?

Intravenous: Delivered straight into a vein through a drip (IV), done by a clinician.

Bioavailability Complete (about 100%) — delivered straight into the bloodstream.

Starting Dose

1.0 mcg/kg

Frequency

Single bolus per test session

Duration

Single-dose research study

Alexamorelin is a research growth-hormone-releasing peptide. In the main human study it was given as a single shot into a vein. The lower 1.0 mcg/kg dose raised growth hormone levels. [1]

Standard Dose

2.0 mcg/kg

The higher IV dose used in the same human study produced a stronger growth hormone response. [1]

Timing

Best time to take

Morning injection on empty stomach 30-60 minutes before food maximizes GH response; second dose in late afternoon if dosing twice daily

With food?

Separate from large meals by at least 30-60 minutes; food delays or blunts response. Light snack acceptable 2+ hours after injection

If stacking

If stacking with GHRH, inject GHRH 5-10 minutes after alexamorelin for synergistic effect. Avoid other GHS compounds on same day

Adjusting Your Dose

Increase if

+No noticeable GH response after 5-7 days at starting dose

+Already using similar compounds and tolerated well

+Aiming for aggressive muscle-building phase with recovery capacity

Decrease if

-Excessive hunger interferes with daily life

-ACTH-related side effects (anxiety, mood changes) emerge

-Water retention becomes problematic

Signs of right dose

✓Increased appetite 1-2 hours post-injection

✓Noticeable energy lift and improved sleep quality

✓Visible muscle pump and recovery improvement within 1-2 weeks

Dosing Calculator

Calculate Your Exact Dose

Step 1: Peptide Weight

Find the weight printed on your peptide vial label

Look here!

The peptide weight is printed on the label

The weight is on the label

Select Weight

Look for a number followed by 'mg' on the vial label (e.g., 5mg, 10mg)

Administration

How do Iuse it?

Reconstitution

What you need

•Bacteriostatic water or normal saline (typically 1-2 mL per vial)

•Sterile syringe and needle (25-27 gauge preferred)

•Alcohol swabs for vial sterilization

•Sterile vial for storage

Example

If vial contains 1 mg alexamorelin and you add 1 mL bacteriostatic water, concentration = 1 mg/mL (1000 mcg/mL). To draw 100 mcg, inject 0.1 mL.

Draw volume (mL) = Desired dose (mcg) ÷ Concentration (mcg/mL). For 150 mcg from 1000 mcg/mL solution: 150 ÷ 1000 = 0.15 mL

Injection

Route

Subcutaneous injection preferred for consistent GH response; intravenous only in clinical/research settings

Best sites

•Lower abdomen (2 inches from navel, avoiding surrounding area)

•Upper thigh or lateral thigh

•Lateral chest wall above waist

•Upper arm outer tricep area

Technique

1.Clean injection site with alcohol swab and let dry 10-15 seconds

2.Pinch skin at injection site to create small fold

3.Insert needle at 45-90 degree angle (steeper = more subcutaneous, shallower = easier)

4.Push plunger slowly to minimize discomfort and ensure proper dispersion

5.Withdraw needle, release skin, and apply gentle pressure for 5 seconds

Storage

Before reconstitution

Lyophilized powder at 2-8°C (refrigerator) in dark, dry location. Protect from light and moisture. Properly sealed vial lasts 1-2 years.

After reconstitution

Reconstituted solution at 2-8°C with bacteriostatic water. Use within 14-30 days. Discard if cloudy, discolored, or shows particles.

Signs of degradation

Solution becomes cloudy or milky instead of clear

Visible particles or crystallization in vial

Color change to yellow, brown, or any discoloration

Unusual odor or signs of bacterial contamination

Sample Daily Schedule

6:00-7:00 AM

100-150 mcg injection

Site: Lower abdomen

On empty stomach 30-60 minutes before breakfast. This is primary GH release window when natural cortisol is rising.

4:00-5:00 PM (optional second dose)

Site: Alternate side of abdomen or thigh

If dosing twice daily, inject 8+ hours after morning dose. Avoids consecutive injections at same site.

Evening (optional third dose for advanced users)

100 mcg injection

Site: Upper thigh or arm

Only if using advanced 3x daily protocol. Too late in day may interfere with sleep.

Safety

Is itsafe?

Safety Profile

Alexamorelin is a research compound with only one small human study (6 subjects), making it much less proven than hexarelin. While it shows promise as a potent GH releaser, the limited human evidence means we don't fully understand long-term effects, optimal dosing in different populations, or rare side effects. Its unique stronger ACTH and aldosterone effects require careful monitoring. Always start low and monitor how your body responds.

This compound has NOT been approved by the FDA and is not available as a pharmaceutical medication. All use is research-based. The single human study was published in 2000 (Eur J Endocrinol), providing our only direct human efficacy data.

Common Side Effects

Experienced by some users

Increased Hunger

Ghrelin receptor activation stimulates appetite, typically 1-3 hours post-injection. Most users report mild to moderate increase.

Management: Time injections around normal meal times or plan snacks accordingly. This side effect usually decreases after 1-2 weeks as your body adapts.

Water Retention

Aldosterone elevation causes sodium and water retention, usually mild to moderate. Can manifest as slight bloating or puffy face.

Management: Maintain hydration and moderate sodium intake. If severe, reduce dose or frequency. Usually resolves within days of stopping.

Injection Site Reactions

Mild redness, itching, or small lumps at injection site. Normal immune response to foreign peptide.

Management: Rotate injection sites to prevent irritation. Use proper sterile technique. Reactions typically fade within hours to days.

Less Common

•Cortisol-Related Mood Changes

•Joint or Muscle Aches

These typically resolve with continued use or dose adjustment.

Stop and Seek Help If

×Severe mood changes or anxiety that don't improve with dose adjustment

×Signs of cardiovascular stress (chest pain, irregular heartbeat, severe headaches)

×Uncontrolled blood sugar elevation or worsening of diabetes

×Persistent allergic reactions or injection site infections

×Completion of planned 4-6 week cycle (take break before restarting)

×New or worsening joint problems that limit training

This is research compound information, not medical advice. Consult a healthcare provider before starting, especially if you have existing health conditions. Stop immediately if you experience serious side effects and seek medical attention.

Interactions

With other peptides

✓Synergistic GH release; inject GHRH 5-10 minutes after alexamorelin for maximum effect

!Redundant since alexamorelin metabolizes to hexarelin; combining offers no additional benefit and increases side effects

✓Complementary for recovery; IGF-1 amplifies growth signaling without competing with alexamorelin's GHS mechanism

✓Synergistic for tissue repair; alexamorelin provides systemic GH while BPC-157 targets local healing

With medications

!Corticosteroids (prednisone, dexamethasone, etc.) - Alexamorelin already elevates cortisol through ACTH; combining risks excessive cortisol with serious metabolic effects

!Dopamine antagonists (antipsychotics like haloperidol) - May reduce GH response; dopamine pathways influence GHS effectiveness

!Somatostatin analogs (octreotide) - Directly block GH secretion, completely negating alexamorelin's mechanism

!Blood pressure medications - Monitor closely; aldosterone elevation may reduce antihypertensive effectiveness

With supplements

✓GHRH-boosting supplements (arginine, ornithine) - Synergistic but additive ACTH response; monitor cortisol effects carefully

✓High-dose electrolyte supplements (sodium, potassium) - Aldosterone elevation already increases sodium retention; excess supplementation risks dangerous electrolyte imbalance

✓Sleep aids or melatonin - Compatible; actually beneficial since quality sleep amplifies GH response

Want the Full Picture?

View the complete Alexamorelin research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.