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Alastin Restorative Eye Treatment Versus Biossance Squalane + Marine Algae Eye Cream

Alastin Restorative Eye Treatment Versus Biossance Squalane + Marine Algae Eye Cream This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Hexapeptide-12 to soften the look of wrinkles and fade the look of dark spots. This anti-aging e

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Alastin Restorative Eye Treatment Versus Biossance Squalane + Marine Algae Eye Cream

This anti-aging eye moisturizer is formulated around Niacinamide and Palmitoyl Hexapeptide-12 to soften the look of wrinkles and fade the look of dark spots.

This anti-aging eye moisturizer is formulated around Squalane and Palmitoyl Tripeptide-5 to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Caprylic/Capric Triglyceride

Cetearyl Alcohol

Dimethicone

Pentylene Glycol

Jojoba Esters

Cetearyl Glucoside

Glyceryl Stearate

Niacinamide

PEG-100 Stearate

Palmitoyl Hexapeptide-12

Palmitoyl Tripeptide-1

Tetrapeptide-30

Albizia Julibrissin Bark Extract

Gallyl Glucoside

Sodium Hyaluronate

Epigallocatechin Gallatyl Glucoside

Darutoside

Dunaliella Salina Extract

Ornithine

Phospholipids

Butyrospermum Parkii Butter Extract

Glycolipids

Betaine

Tremella Fuciformis Sporocarp Extract

Beta-Glucan

Silica

Hdi/Trimethylol Hexyllactone Crosspolymer

Propanediol

Squalane

Polysorbate 20

Polyacrylate-13

Xanthan Gum

1,2-Hexanediol

Benzyl Alcohol

Dehydroacetic Acid

Helianthus Annuus Seed Oil

Levulinic Acid

P-Anisic Acid

Potassium Sorbate

Sodium Benzoate

Sodium Hydroxide

Sorbitan Isostearate

Tocopherol

Disodium EDTA

Caprylyl Glycol

Polyisobutene

Caprylhydroxamic Acid

Phenoxyethanol

Propyl Gallate

Ethylhexylglycerin

Water, Glycerin, Caprylic/Capric Triglyceride, Cetearyl Alcohol, Dimethicone, Pentylene Glycol, Jojoba Esters, Cetearyl Glucoside, Glyceryl Stearate, Niacinamide, PEG-100 Stearate, Palmitoyl Hexapeptide-12, Palmitoyl Tripeptide-1, Tetrapeptide-30, Albizia Julibrissin Bark Extract, Gallyl Glucoside, Sodium Hyaluronate, Epigallocatechin Gallatyl Glucoside, Darutoside, Dunaliella Salina Extract, Ornithine, Phospholipids, Butyrospermum Parkii Butter Extract, Glycolipids, Betaine, Tremella Fuciformis Sporocarp Extract, Beta-Glucan, Silica, Hdi/Trimethylol Hexyllactone Crosspolymer, Propanediol, Squalane, Polysorbate 20, Polyacrylate-13, Xanthan Gum, 1,2-Hexanediol, Benzyl Alcohol, Dehydroacetic Acid, Helianthus Annuus Seed Oil, Levulinic Acid, P-Anisic Acid, Potassium Sorbate, Sodium Benzoate, Sodium Hydroxide, Sorbitan Isostearate, Tocopherol, Disodium EDTA, Caprylyl Glycol, Polyisobutene, Caprylhydroxamic Acid, Phenoxyethanol, Propyl Gallate, Ethylhexylglycerin

Sorbitan Olivate

Cetearyl Olivate

Glyceryl Stearate Se

Panthenol

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Cetyl Palmitate

Spilanthes Acmella Flower Extract

Palmitoyl Tripeptide-5

Sorbitan Palmitate

Astaxanthin

Citric Acid

Water, Caprylic/Capric Triglyceride, Squalane, Glycerin, Sorbitan Olivate, Cetearyl Olivate, Jojoba Esters, Glyceryl Stearate Se, Panthenol, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Palmitate, Spilanthes Acmella Flower Extract, Palmitoyl Tripeptide-5, Sorbitan Palmitate, Dunaliella Salina Extract, Astaxanthin, Sodium Hyaluronate, Phenoxyethanol, Ethylhexylglycerin, Tocopherol, Citric Acid

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

We don't have a description for Dunaliella Salina Extract yet.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Jojoba Esters is a wax created from Jojoba oil. It is an emollient and film-forming ingredient. In bead form, it is an exfoliator.

This ingredient has high oxidative stability, meaning it doesn't break down when exposed to oxygen.

Its similarity to our skin's natural oils makes it a great emollient. Emollients help soften and soothe our skin by creating a barrier on top. This barrier helps trap moisture in, keeping skin hydrated.

It is created using either the hydrogenation or transesterification processes on jojoba oil.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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