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AHK-Cu and Skin Cell Support - Biotech Peptides

AHK-Cu and Skin Cell Support by Dr. Usman | Jun 13, 2022 | Research This peptide could be of interest to researchers because of its speculated ability to improve follicle growth and potentially prevent cell aging impacts on the skin barrier. According to specu

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AHK-Cu and Skin Cell Support

by Dr. Usman | Jun 13, 2022 | Research

This peptide could be of interest to researchers because of its speculated ability to improve follicle growth and potentially prevent cell aging impacts on the skin barrier. According to speculative research, the primary interest might be AHK-Cu’s potential effect on fibroblasts – cells considered to be responsible for the growth and maintenance of the extracellular matrix.

The Potential of AHK-Cu

According to speculative research, AHK-cu might prove fruitful in research studies focusing on the following areas:

Hair Follicle Damage: AHK-Cu might impact follicle damage loss in two ways. First, it might improve the growth of blood vessels by enhancing the secretion of VEGF. Second, it may potentially down-regulate the action of TGF beta-1. Blood vessels and enhanced blood flow are speculated to be necessary for supplying vital nutrients to hair follicles. AHK-Cu’s research on animal models might indicate that its actions are not limited to the increase of blood flow to existing hair follicles, as it might bolster the growth of new hair follicles by promoting the growth of blood vessels. Dihydrotestosterone (DHT), the active form of testosterone, is speculated exert action via TGF beta-1. Therefore, the down-regulation of TGF beta-1 might allow for the direct reduction of DHT by AHK-Cu.

Hair Follicle Growth Stimulation: Hair follicles appear go through three stages of development – anagen, catagen, and telogen. The anagen stage is considered to be the active stage of hair growth. This stage of development is notable via brisk division and differentiation. Research suggests that AHK-cu could potentially help follicles remain in the anagen stage and potentially retain strands in the anagen stage for about 3-5 years.

Wrinkles and Cell Support: Copper peptides and copper have been speculated to be potential stimulants of endogenous collagen synthesis. Collagen, deemed to be one of the integral molecules in extracellular matrix of the skin (ECM), contributes to cell turnover and supports a function skin structure. Supplementing a natural decline in collagen and related proteins has been suggested to reduce the overall rate of wrinkle formation and depth. The cell aging of the skin appears result in the rapid deterioration in the number of fibroblasts. This might cause a speculated reduction in the amount of elastin and collagen in the skin, allowing for the emergence of aging biomarkers.

Exposure to AHK-Cu might help counteract these impacts by potentially stimulating the growth and development of new fibroblasts. Through its speculated effect on TGF beta-1 and VEGF, AHK-Cu might activate the replication and development of cells termed fibroblasts. The abundance of fibroblasts in the skin might usher in an increase in collagen and elastin. AHK-Cu, according to speculative research, might encourage the production of Type 1 collagen, potentially up to 300%.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

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by Dr. Usman | Jan 6, 2022 | Research Mitochondria are considered to play complex roles in energy production, cellular signaling, and metabolism, serving as the cell’s powerhouse. Earlier assumptions about the control of mitochondria’s function, maintenance, and biogenesis by the nucleus may be reconsidered in light of newer studies suggesting that some mitochondria possess a genomic sequence, translating into proteins that may affect the genomic expression of the nucleus. Research on the genomic sequence of mitochondria suggests that the rRNA possesses Open Reading Frames (ORFs), transcribing into small peptides, including Humanin (HN), Small Humanin-Like Peptides 1-6 (SHLPs), and Mitochondrial ORF-encoded peptide (MOTS-c). These peptides appear to bind to specific receptors in and out of the cells, exerting various speculated biological effects. The detectable concentration of Humanin in the skeletal muscles, hypothalamus, and cortex of murine models declined progressively with advancing age. Humanin may potentially be a subsequent biomarker of age. Humanin is suggested to have diverse biological functions, including cytoprotective and metabolic roles. Cytoprotective roles may involve protection against oxidative stress and injury, anti-inflammatory responses, neuroprotection, and cardioprotection. Metabolic protection roles may involve metabolic hemostasis, ATP production, reduction in visceral fat, and glucose-stimulated insulin secretion. Myocardial fibrosis may appear either as an age-related physiological change or due to various pathological phenomena such as Myocardial Infarction and ischemic reperfusion injury, contributing to cardiac dysfunction. It is speculated to affect both systolic and diastolic function and eventually progress to heart failure. The number of fibroblast cells present in cardiac tissue may directly correlate with the age of the heart tissue. Considering its ratio to the cardiac striated cells present may indicate the extent of age-related degenerative change in the heart. These fibroblasts may lead to the secretion of extracellular matrix proteins such as collagen type 1 that favors fibrosis.

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