Adipotide Protocol — Complete Dosing & Administration Guide

Dosing

How muchdo I take?

Subcutaneous: A small injection into the fatty layer just under the skin — the same way insulin is given.

Bioavailability High — most of the dose reaches your bloodstream, just more gradually than an IV.

Starting Dose

0.10 mg/kg

Frequency

Once daily

Duration

About 2 weeks before stepping up

Adipotide is research-only and has never been approved for people. These numbers come from a dose-finding study in obese monkeys, where the dose was raised step by step every 2 weeks. The first human Phase 1 study started even lower, at 0.03 mg/kg daily. [2]

Standard Dose

0.25 mg/kg

About 2 weeks at this step

Middle step in the monkey dose-finding study. Not an approved human dose. [2]

Advanced Dose

0.43 mg/kg

Up to ~3-4 weeks at this level (studies ran 28 days at the top dose)

This was the best-working ("optimal") dose in obese monkeys, leading to about 10.6% body-weight loss over 28 days. It is from animal research and is not an approved or established human dose. [2]

Timing

Best time to take

Morning, at a consistent time each day

With food?

Can be administered with or without food. Ensure adequate hydration throughout the day.

If stacking

If using BPC-157 for potential renal support, administer at a different time of day. Avoid combining with other nephrotoxic substances.

Adjusting Your Dose

Increase if

+Tolerating current dose well with stable kidney markers

+Minimal side effects after 1-2 weeks

+Fat loss progress has plateaued at current dose

+Serum creatinine remains within normal range

Decrease if

-Serum creatinine rises above normal range

-Significant proteinuria or glucosuria develops

-Signs of dehydration despite adequate fluid intake

-Any concerning changes in urination patterns

Signs of right dose

✓Steady fat loss of 2-3% body weight per week

✓Stable kidney function markers

✓Improved insulin sensitivity on bloodwork

✓No significant side effects

Dosing Calculator

Calculate Your Exact Dose

Step 1: Peptide Weight

Find the weight printed on your peptide vial label

Look here!

The peptide weight is printed on the label

The weight is on the label

Select Weight

Look for a number followed by 'mg' on the vial label (e.g., 5mg, 10mg)

Administration

How do Iuse it?

Reconstitution

What you need

•Bacteriostatic water (BAC water)

•Insulin syringe (29-31 gauge)

•Alcohol swabs

•Sterile vial of Adipotide powder

•Calculator for dose calculation based on body weight

Example

10mg vial + 2mL BAC water = 5mg/mL concentration. For an 80kg person at 0.25 mg/kg dose: 80 x 0.25 = 20mg needed. At 5mg/mL, draw 4mL total (split into multiple injections if needed).

Calculate your dose in mg by multiplying your body weight in kg by the mg/kg dose. Then divide by your concentration to get the volume to inject.

Injection

Route

Subcutaneous injection once daily

Best sites

•Abdomen (2 inches from navel)

•Front of thigh (middle third)

•Upper arm (outer area)

Technique

1.Calculate your dose based on body weight and verify the math

2.Clean injection site thoroughly with alcohol swab and let dry

3.Pinch skin to create a fold at the injection site

4.Insert needle at 45-90 degree angle depending on body composition

5.Inject slowly and steadily

6.Remove needle and apply light pressure - do not rub

Storage

Before reconstitution

Store lyophilized powder at -20°C for long-term storage (up to 2 years) or 2-8°C for short-term storage (up to 3 months). Keep in original container protected from light. Do not expose to repeated freeze-thaw cycles.

After reconstitution

Refrigerate immediately at 2-8°C. Store upright to prevent contamination of the stopper. Use within 14 days of reconstitution. Never freeze reconstituted solution as this will destroy the peptide.

Signs of degradation

Cloudy or discolored solution (should be clear)

Visible particles or floaters in solution

Solution that fails to fully dissolve

Any unusual odor

Sample Daily Schedule

Morning (7:00-9:00 AM)

Calculated based on body weight and current tier injection

Site: Rotate between abdomen, thigh, and arm

Take at the same time each day. Drink at least 8-10 glasses of water daily. Monitor urine color - should be light yellow.

Safety

Is itsafe?

Safety Profile

Adipotide has been extensively studied in mice, rats, and three species of primates with consistent results. The primary safety concern is dose-dependent kidney effects, which were reversible upon stopping treatment in all studies. No cardiovascular, neurological, or hepatic adverse events were observed. The compound shows remarkable selectivity - lean animals given the same doses experienced no weight loss, suggesting it specifically targets excess fat tissue.

Safety data comes from well-designed primate studies published in peer-reviewed journals including Science Translational Medicine. However, there are no human clinical trials, so the full safety profile in humans remains unknown. The reversibility of kidney effects in primates is encouraging but requires validation in human studies.

Common Side Effects

Experienced by some users

Elevated Serum Creatinine

The most consistently observed effect in primate studies, indicating the kidneys are processing the compound.

Management: Monitor with regular blood tests. Usually normalizes within 4 weeks of stopping treatment. Stay well-hydrated.

Proteinuria

Mild to moderate protein appearing in urine, reflecting kidney filtration changes.

Management: Monitor with urinalysis. Reduce dose if marked. Ensure adequate hydration.

Glucosuria

Glucose appearing in urine even with normal blood sugar, due to effects on kidney tubules.

Management: Monitor blood glucose to ensure it remains normal. Not typically concerning if blood sugar is stable.

Reduced Appetite

Decreased food intake observed in all treated animals - appears to be genuine appetite reduction rather than nausea.

Management: Ensure adequate protein intake despite reduced appetite. This effect contributes to weight loss.

Less Common

•Mild Dehydration

•Injection Site Reactions

These typically resolve with continued use or dose adjustment.

Stop and Seek Help If

×Serum creatinine rises significantly above your baseline

×Marked proteinuria that persists or worsens

×Signs of kidney problems (pain in lower back, changes in urination)

×Severe or persistent dehydration despite adequate fluid intake

×Any allergic reaction (rash, swelling, difficulty breathing)

×Completion of the recommended 4-week treatment cycle

Adipotide is a research compound without FDA approval. Use only under medical supervision with regular kidney function monitoring. Stop immediately and consult a healthcare provider if you experience any concerning symptoms.

Interactions

With other peptides

✓May provide protective effects for kidneys - consider using for support

✓No known interactions, but avoid adding kidney stress

!Both target fat loss through different mechanisms - use caution with combination

!Different mechanisms but overlapping goals - not recommended to combine

With medications

!NSAIDs (Ibuprofen, etc.) - Can compound kidney stress - avoid during Adipotide use

!ACE Inhibitors - May affect kidney function - monitor closely if combining

!Diuretics - Increases dehydration risk significantly - avoid combination

✓Metformin - Generally safe but monitor kidney function more frequently

With supplements

✓Electrolytes - Highly recommended to maintain proper hydration and mineral balance

✓Protein supplements - Recommended to preserve muscle mass during rapid fat loss

✓Creatine - May confound creatinine monitoring - consider stopping during treatment

✓High-dose Vitamin C - Very high doses may affect kidney stone risk - use moderate amounts

Want the Full Picture?

View the complete Adipotide research profile including mechanism of action, clinical studies, effectiveness timeline, and FAQ.