Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

ACO Spotless Spot Treatment Overnight Versus The Ordinary Niacinamide 10% + Zinc 1%

ACO Spotless Spot Treatment Overnight Versus The Ordinary Niacinamide 10% + Zinc 1% This acne treatment is formulated around Zinc Oxide and Salicylic Acid to clear breakouts and balance excess oil. This oil-control serum is formulated around Niacinamide and Zi

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

ACO Spotless Spot Treatment Overnight Versus The Ordinary Niacinamide 10% + Zinc 1%

This acne treatment is formulated around Zinc Oxide and Salicylic Acid to clear breakouts and balance excess oil.

This oil-control serum is formulated around Niacinamide and Zinc PCA to balance excess oil and refine the look of pores.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Zinc Oxide

Propylene Glycol

Glycerin

Xanthan Gum

Salicylic Acid

Lactic Acid

Allantoin

Sodium Citrate

Phenoxyethanol

Water, Zinc Oxide, Propylene Glycol, Glycerin, Xanthan Gum, Salicylic Acid, Lactic Acid, Allantoin, Sodium Citrate, Phenoxyethanol

Niacinamide 10%

Pentylene Glycol

Zinc PCA 1%

Dimethyl Isosorbide

Tamarindus Indica Seed Gum

Isoceteth-20

Ethoxydiglycol

Chlorphenesin

Water, Niacinamide 10%, Pentylene Glycol, Zinc PCA 1%, Dimethyl Isosorbide, Tamarindus Indica Seed Gum, Xanthan Gum, Isoceteth-20, Ethoxydiglycol, Phenoxyethanol, Chlorphenesin

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →