928 - Gene ResultCD9 CD9 molecule [ (human)]

Official Symbol CD9provided by HGNC Official Full Name CD9 moleculeprovided by HGNC Primary source HGNC:HGNC:1709 See related Ensembl:ENSG00000010278 MIM:143030; AllianceGenome:HGNC:1709 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as MIC3; MRP-1; BTCC-1; DRAP-27; TSPAN29; TSPAN-29 Summary This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011] Expression Broad expression in esophagus (RPKM 210.8), prostate (RPKM 168.1) and 21 other tissues See more Orthologs all Try the new Gene page
Try the new Transcripts and proteins table Location: 12p13.31 Exon count: 13

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (6199946..6238266)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (6207556..6245881)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (6309112..6347432)

Chromosome 12 - NC_000012.12

Genomic Sequence:

Related articles in PubMed

1. Specific targeting of human inflamed endothelium and in situ vascular tissue transfection by the use of ultrasound contrast agents. Barreiro O, et al. JACC Cardiovasc Imaging, 2009 Aug. PMID 19679288
2. Tetraspanin CD9 Is a Positive Regulator of Filovirus Egress. Anand LK, et al. Viruses, 2026 Jan 13. PMID 41600867, Free PMC Article
3. [Expression and gene mutation of cluster of differentiation 9 in lung cancer cells induced by mineral powder in Gejiu]. Liang R, et al. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, 2007 Sep. PMID 17997888
4. Fc gamma II receptor-mediated platelet activation induced by anti-CD9 monoclonal antibody opens Ca2+ channels which are distinct from those associated with Ca2+ store depletion. Kuroda K, et al. J Immunol, 1995 Nov 1. PMID 7594604
5. CD9 clustering and formation of microvilli zippers between contacting cells regulates virus-induced cell fusion. Singethan K, et al. Traffic, 2008 Jun. PMID 18363777, Free PMC Article

See all (760) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. CD9 promotes TbetaR2-TbetaR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia.

   Title: CD9 promotes TβR2-TβR1 association driving the transition of human dermal fibroblasts to myofibroblast under hypoxia.

2. Immunohistochemical analysis of CD9, CD29 and epithelial to mesenchymal transition in triple-negative breast cancer.

   Title: Immunohistochemical analysis of CD9, CD29 and epithelial to mesenchymal transition in triple-negative breast cancer.

3. CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia.

   Title: CD9 shapes glucocorticoid sensitivity in pediatric B-cell precursor acute lymphoblastic leukemia.

4. High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer.

   Title: High expression of CD9 and Epidermal Growth Factor Receptor promotes the development of tongue cancer.

5. CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway.

   Title: CD9 co-operation with syndecan-1 is required for a major staphylococcal adhesion pathway.

6. Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China.

   Title: Prognostic implications of CD9 in childhood acute lymphoblastic leukemia: insights from a nationwide multicenter study in China.

7. Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles.

   Title: Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles.

8. Small extracellular vesicles have distinct CD81 and CD9 tetraspanin expression profiles in plasma from rheumatoid arthritis patients.

   Title: Small extracellular vesicles have distinct CD81 and CD9 tetraspanin expression profiles in plasma from rheumatoid arthritis patients.

9. Prognostic significance of tetraspanin CD9 and oncogenic epidermal growth factor receptor in tongue squamous cell carcinoma survival.

   Title: Prognostic significance of tetraspanin CD9 and oncogenic epidermal growth factor receptor in tongue squamous cell carcinoma survival.

10. Lack of involvement of CD63 and CD9 tetraspanins in the extracellular vesicle content delivery process.

    Title: Lack of involvement of CD63 and CD9 tetraspanins in the extracellular vesicle content delivery process.

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
New gene functions in megakaryopoiesis and platelet formation.

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Recruitment of Env to tetraspanin-enriched micro domains (TEMs) is required for cell-cell fusion repression by CD9 and CD63	PubMed
	env	Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection	PubMed
	env	Overexpression of CD81 and CD9 renders cells less susceptible to HIV-1 gp120/gp41-mediated syncytia formation; antibodies raised against CD9 and CD81 enhance syncytia formation	PubMed
Pr55(Gag)	gag	HIV-1 Gag recruits and traps CD9 to Gag assembly sites at the plasma membrane, which is dependent upon Gag polymerization and the presence of cholesterol	PubMed
	gag	HIV-1 Gag proteins co-localize with tetraspanins CD9, CD81, and CD82 in CD63-enriched micro domains	PubMed
	gag	Env-mediated cell-cell fusion repression by CD9 and CD63 requires the presence of HIV-1 Gag	PubMed
matrix	gag	HIV-1 MA co-localizes with CD9 in monocyte-derived macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Markers

• SHGC-132041 (e-PCR)
  • UniSTS:182539

• G10611 (e-PCR)
  • UniSTS:39698

• A010B11 (e-PCR)
  • UniSTS:44068

• STS-M38690 (e-PCR)
  • UniSTS:72251

• D12S1887 (e-PCR)
  • UniSTS:32084

• RH44617 (e-PCR)
  • UniSTS:50043

• GDB:384746 (e-PCR)
  • UniSTS:13450

• G33070 (e-PCR)
  • UniSTS:117646

• SHGC-34900 (e-PCR)
  • UniSTS:65429

• D12S1005 (e-PCR)
  • UniSTS:149946

Preferred Names CD9 antigen Names 5H9 antigen BA-2/p24 antigen CD9 antigen (p24) antigen CD9 cell growth-inhibiting gene 2 protein leukocyte antigen MIC3 motility related protein-1 tetraspanin-29

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_055677.1 RefSeqGene

   Range 5694..43560 Download GenBank, FASTA, Sequence Viewer (Graphics), LRG_1189

mRNA and Protein(s)

1. NM_001330312.2 → NP_001317241.1  CD9 antigen isoform 2

   Status: REVIEWED

   Description Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2 and 11-14 all encode the same isoform (2). Source sequence(s) AI003581, AL523128, X60111 Consensus CDS CCDS81654.1 UniProtKB/TrEMBL A6NNI4, B4DPP0 Related ENSP00000494858.1, ENST00000642746.1 Conserved Domains (1) summary cd03152
   Location:42 → 124 CD9_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ...

2. NM_001413241.1 → NP_001400170.1  CD9 antigen isoform 3

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/TrEMBL A0A087WU13, A0ACI8T8V1 Related ENSP00000478288.2, ENST00000610354.6

3. NM_001413242.1 → NP_001400171.1  CD9 antigen isoform 4

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/TrEMBL A0ACI8T8V1, G8JLH6 Related ENSP00000371959.5, ENST00000382519.10

4. NM_001413243.1 → NP_001400172.1  CD9 antigen isoform 1

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/Swiss-Prot D3DUQ9, P21926, Q5J7W6, Q96ES4 UniProtKB/TrEMBL A0ACI8T8V1 Related ENSP00000371958.1, ENST00000382518.6

5. NM_001413244.1 → NP_001400173.1  CD9 antigen isoform 5

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/TrEMBL A0ACI8T8V1 Related ENSP00000680206.1, ENST00001010389.1

6. NM_001413245.1 → NP_001400174.1  CD9 antigen isoform 6

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/TrEMBL A0ACI8T8V1

7. NM_001413246.1 → NP_001400175.1  CD9 antigen isoform 7

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/TrEMBL A0ACI8R9U7, A0ACI8T8V1 Related ENSP00000564400.1, ENST00000894341.2

8. NM_001413247.1 → NP_001400176.1  CD9 antigen isoform 8

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/TrEMBL A0ACI8T8V1 Related ENSP00000595043.1, ENST00000924984.2

9. NM_001413248.1 → NP_001400177.1  CD9 antigen isoform 9

   Status: REVIEWED

   Source sequence(s) AC006057 UniProtKB/TrEMBL A0ACI8T8V1

10. NM_001413249.1 → NP_001400178.1  CD9 antigen isoform 2

    Status: REVIEWED

    Source sequence(s) AC006057 UniProtKB/TrEMBL A6NNI4, B4DPP0 Related ENST00000676788.1

11. NM_001413250.1 → NP_001400179.1  CD9 antigen isoform 2

    Status: REVIEWED

    Source sequence(s) AC006057 UniProtKB/TrEMBL A6NNI4, B4DPP0

12. NM_001413251.1 → NP_001400180.1  CD9 antigen isoform 2

    Status: REVIEWED

    Source sequence(s) AC006057 UniProtKB/TrEMBL A6NNI4, B4DPP0 Related ENSP00000371955.2, ENST00000382515.7

13. NM_001413252.1 → NP_001400181.1  CD9 antigen isoform 2

    Status: REVIEWED

    Source sequence(s) AC006057 UniProtKB/TrEMBL A6NNI4, B4DPP0 Related ENSP00000495090.1, ENST00000646407.1

14. NM_001769.4 → NP_001760.1  CD9 antigen isoform 1

    See identical proteins and their annotated locations for NP_001760.1

    Status: REVIEWED

    Description Transcript Variant: This variant (1) encodes isoform 1. Variants 1 and 5 both encode the same isoform (1). Source sequence(s) AI003581, BM763066, X60111 Consensus CDS CCDS8540.1 UniProtKB/Swiss-Prot D3DUQ9, P21926, Q5J7W6, Q96ES4 UniProtKB/TrEMBL A0ACI8T8V1 Related ENSP00000009180.4, ENST00000009180.10 Conserved Domains (2) summary cd03152
    Location:111 → 193 CD9_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD9 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans ... pfam00335
    Location:10 → 217 Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08