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5-Amino-1MQ Peptide Guide

5-Amino-1MQ Peptide Guide Research-based overview of 5-Amino-1MQ and NNMT inhibition. This page covers key concepts around 5-amino-1mq, with links to dosage calculators, protocols, and comparison guides where relevant. PeptideUniv provides interactive tools an

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

5-Amino-1MQ Peptide Guide

Research-based overview of 5-Amino-1MQ and NNMT inhibition. This page covers key concepts around 5-amino-1mq, with links to dosage calculators, protocols, and comparison guides where relevant. PeptideUniv provides interactive tools and structured content for research and education only; we do not provide medical advice.

What is 5-Amino-1MQ?

5-Amino-1MQ is a synthetic small molecule that targets NNMT (nicotinamide N-methyltransferase). NNMT sits at a crossroads between NAD+ biology (energy and repair signaling) and methyl donor balance (SAM/SAH). When NNMT activity is high in fat tissue in some obesity models, it can shift metabolite pools toward fat storage.

Educational information only. Not medical advice.

Benefits

Preclinical: reduced fat mass and body weight in obesity models

Preclinical: increased intracellular NAD+ and SAM pools reported in experiments

Mechanism of action

Primary pathways (studied):

NNMT-mediated nicotinamide methylation (nicotinamide + SAM → 1-MNA + SAH)

NAD+ salvage pathway (indirect)

Methionine cycle and methylation potential (SAM/SAH balance)

Adipocyte lipid metabolism (lipogenesis and storage programs)

Cell-level effects (studied):

Direct inhibition of NNMT enzymatic activity

Lower intracellular 1-MNA production

Higher intracellular NAD+ pools reported in preclinical work

Reduced lipogenesis in cultured adipocytes

System-level effects (studied):

Reduced body weight and white adipose tissue mass in obese mice (preclinical)

Smaller adipocyte size in mouse models (preclinical)

Effects appear not primarily driven by appetite suppression in key mouse studies (preclinical)

Half-life

Half-life: Not fully established

Duration: Not fully established

Peak time: Not fully established

Storage

Storage depends on formulation (lyophilized powder vs reconstituted solution) and the manufacturer. Follow the product label when available.

Dry / lyophilized: commonly kept cool, dry, and protected from light.

Reconstituted: commonly refrigerated and used within the supplier’s stated window.

Avoid: repeated heat exposure and unnecessary freeze–thaw cycles.

Reconstitution guide

For measurement math (mg, mL, and U-100 units), use:

Peptide reconstitution guide

Peptide reconstitution calculator

Protocol overview

Protocol pages summarize common research-style structures and measurement concepts. They do not provide individualized instructions.

Research review and sources

Reviewed by: PeptideUniv

Updated: March 26, 2026

Human trial evidence exists, but the practical takeaways still depend on population, endpoint, and how long the compound has been studied.

Key research takeaways surfaced on this page

Research context available in the underlying profile.

Primary references and supporting sources

Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction — Recent 5A1MQ preclinical paper covering obesity, glucose, and liver outcomes.

Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome — Review article that explains the rationale for targeting NNMT in metabolic research.

Dosage and calculator

Related tools

Use these tools and guides together for research and education.

Ready to stop piecing this together by hand? Open the full app to run the calculator, save the protocol, and keep reminders in one place.

Suggested links

Peptide Reconstitution Guide: BAC Water, Mixing, and Storage

For educational and research purposes only. Not medical advice. Consult a licensed healthcare professional for personal guidance.

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

Related questions

01Frequently Asked Questions About 5-Amino-1MQ

Straight answers on reconstitution, dosing, and safety, everything you need to research with confidence. For research reference only.

Source: peptidemind.com ↗
comparison

Fat storage versus fat burning

NNMT does not just affect NAD+ levels. It also influences gene expression patterns that control whether cells store or burn fat. When NNMT activity is high, fat cells become more efficient …

Source: seekpeptides.com
comparison

NNMT Inhibitor 5-Amino-1MQ Versus Peptide Therapy Options

5-Amino-1MQ targets NNMT and is a small molecule. GLP-1 or GIP/GLP-1 metabolic drugs work through incretin hormone receptors and have regulator-reviewed indications when used as approved pr…

Source: peptidedosages.com
Research context

Read sources and limitations before applying a claim.

Community Research

Join others researching 5-Amino-1MQ — share findings, ask questions, and learn from real experiences 5-Amino-1MQ is a small molecule NNMT (nicotinamide N-methyltransferase) inhibitor that enhances cellular NAD+ levels and mitochondrial function. Not a true peptide, but a small molecule compound used in longevity and metabolic optimization protocols. Inhibits NNMT enzyme systemically, preventing NAD+ degradation and maintaining elevated cellular NAD+ levels to support mitochondrial function and metabolic processes.

Source: peptide-db.com ↗

Researchers Cited in This Article

The researchers below authored or co-authored publications cited in this article. Listing them here identifies sources; it does not mean they wrote, independently reviewed, sponsored, or endorsed this PeptideDosages.com article. The site author is identified in the article byline.

Source: peptidedosages.com ↗
Practical and safety references

These excerpts are educational, not personalised medical instructions.

Dosage reference

5-Amino-1MQ Dosage Protocols

Standard Fat Loss Protocol 50 mg Once daily with food 8-12 weeks Accelerated Protocol 100 mg/day (50 mg twice daily) Twice daily with meals Metabolic Stack Protocol 50-100 mg/day oral Once or twice daily Standard Fat Loss Protocol: Start here to assess tolerance. Take with breakfast or lunch. Avoid taking late in the day on the off chance it affects sleep (rare but reported). Most users see gradual results starting around week 4. Accelerated Protocol: Split the dose between breakfast and lunch. This is the upper range commonly used. Do not exceed 100 mg/day without medical guidance. Better results when combined with regular exercise and a moderate caloric deficit. Metabolic Stack Protocol: When stacking with MOTS-c or a GLP-1 agonist, start at 50 mg/day and increase only if well tolerated. The combination targets multiple metabolic pathways simultaneously, so starting conservatively is wise. These are general guidelines for research purposes. Always consult a healthcare professional before use.

Source: peptidesexplorer.com ↗
Potential benefits

5-Amino-1MQ Peptide: Benefits, Dosage & Safety (2026)

5-Amino-1MQ Peptide: Benefits, Dosage & Safety (2026) 5-Amino-1MQ is a small-molecule NNMT inhibitor studied for fat loss and NAD+, not a true peptide. A research guide to its benefits, dosage, and side effects. The compound sold as the 5-Amino-1MQ peptide is a synthetic small molecule that blocks an enzyme called NNMT, and early research ties that action to faster fat loss and higher cellular NAD+. It sells under the "peptide" label almost everywhere, yet it is not one. There are no amino acids in it and no peptide bonds. This guide walks through what the molecule is, how it works, what the studies found, how it gets dosed in research, and where the safety picture still has holes. One frame before the details. Almost all of the evidence comes from cells and mice. Read every benefit below as "studied in the lab," not "proven in people." What is 5-Amino-1MQ? 5-Amino-1MQ is a small-molecule inhibitor of nicotinamide N-methyltransferase, an enzyme almost always shortened to NNMT. Its full chemical name is 5-amino-1-methylquinolinium, it carries the CAS number 685079-15-6, and it weighs roughly 159 daltons. That is tiny. A research peptide like BPC-157 weighs about 1,419 daltons and is built from 15 amino acids; this compound is a single ring system with none. Suppliers sell the reference standard as an iodide salt, and the literature describes it as a selective NNMT inhibitor with an IC50 near 1.2 micromolar, meaning it shuts the enzyme down at low concentrations without hittin…

Source: peptidemind.com ↗
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